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| Instrumentation | |
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| Basics of Mass Spectrometry | |
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| A Brief History of Mass Spectrometry | |
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| Unique Features of Mass Spectrometry | |
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| Basic Principles of Mass Spectrometry | |
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| Anatomy of a Mass Spectrum | |
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| Atomic and Molecular Masses | |
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| Mass-to-charge Ratio | |
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| General Applications | |
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| Overview of the Chapter | |
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| Excercises | |
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| References | |
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| Modes of Ionization | |
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| Why Ionization is Required? | |
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| General Construction of the Ion Source | |
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| Gas-Phase Ionization Techniques | |
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| Electron Ionization | |
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| Chemical Ionization | |
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| Charge-exchange Chemical Ionization | |
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| Negative-Ion Chemical Ionization | |
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| Photoionization | |
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| Field Ioniztion | |
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| Metastable Atom Bombardment Ionization | |
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| Condensed-phase Ionization Techniques: Ionization of | |
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| Solid-State Samples | |
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| Field Desorption | |
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| Plasma Desorption Ionization | |
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| Secondary-ion Mass Spectrometry | |
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| Fast Atom Bombardment | |
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| Laser Desorption/Ionization | |
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| Matrix-Assisted Laser Desorption/Ionization | |
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| Analysis of Low Molecular Mass Compounds | |
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| Atmospheric Pressure | |
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| Surface-enhanced Laser Desorption/Ionization | |
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| Condensed-phase Ionization Techniques: Ionization of Liquid-State Samples | |
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| Thermospray Ionization | |
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| Atmospheric Pressure Chemical Ionization | |
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| Atmospheric Pressure Photoionization | |
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| Electrospray Ionization | |
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| Mechanism of Electrospray Ionization | |
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| Sample Consideration | |
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| Nanoelectrospray Ionization | |
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| Desorption Electrospray Ionization | |
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| DART Ion Source | |
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| OVerview of the Chapter | |
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| Exercises | |
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| Additional Reading | |
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| References | |
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| Mass Analysis and Ion Detection | |
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| Mass Resolution | |
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| Kinetic Energy of Ions | |
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| Mass Analyzers | |
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| Magnetic Sector Mass Spectrometers | |
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| Working Principle of a Magnetic Analyzer | |
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| Working Principle of an Electrostatic Analyzer | |
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| Working Principle of Double-Focusing Magnetic Sector Mass Spectrometers | |
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| Performance Characteristics | |
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| Quadrupole Mass Spcetrometers | |
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| Working Principle | |
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| Performance Characteristics | |
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| RF-only quadrupole | |
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| Time-of-Flight Mass Spectrometers | |
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| Working Principle | |
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| Delayed Extraction of Ions | |
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| Reflectron TOF Instrument | |
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| Orthogonal Acceleration TOF Mass Spectrometer | |
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| Performance Characteristics | |
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| Quadrupole Ion Trap Mass Spectrometers | |
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| Working Principle | |
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| Operational Modes | |
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| Performance Characteristics | |
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| Linear Ion Trap Mass Spectrometers | |
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| Rectilinear Ion Trap | |
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| Fourier-Transform Ion Cyclotron Resonance Mass Spectrometers | |
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| Working Principle | |
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| Performance Characteristics | |
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| Orbitrap Mass Analyzer | |
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| Ion Mobility Mass Spectrometers | |
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| Detectors | |
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| Faraday Cup Detector | |
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| Electron Multipliers | |
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| Photomultiplier detectors | |
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| Post-acceleration Detectors | |
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| Low-temperature Calorimetric Detectors for High Mass Ions | |
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| Focal-plane Detectors | |
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| Overview of the Chapter | |
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| Excercises | |
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| Additional Reading | |
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| References | |
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| Tandem Mass Spectrometry | |
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| Basic Principles of Tandem Mass Spectrometry | |
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| Types of Scan Functions | |
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| Ion Activation and Dissociation | |
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| Collision-induced Dissociation | |
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| Surface-induced Dissociation | |
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| Absorption of Electromagnetic Radiations | |
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| Electron-capture Dissociation | |
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| Reactions in Tandem Mass Spectrometry | |
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| Tandem Mass Spectrometry Instrumentation | |
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| Magnetic Sector Tandem Mass Spectrometers | |
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| Tandem Mass Spectrometry with Multiple Quadrupole Devices | |
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| Tandem Mass Spectrometry with Time-of-Flight Instruments | |
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| Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer | |
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| Tandem Mass Spectrometry with an FT-ICR Mass Spectrometer | |
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| Tandem Mass Spectrometry with Hybrid Instruments | |
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| Overview of the Chapter | |
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| Excercises | |
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| Additional Reading | |
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| References | |
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| Hyphenated Separation Techniques | |
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| Benefits of the Coupling of Separation Devices with Mas | |