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| Preface | |
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| Acknowledgments | |
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| Introduction | |
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| Biomaterials | |
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| Introduction | |
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| Definition | |
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| Metallic Biomaterials | |
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| Basis of Structure-Property Relationships | |
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| Corrosion | |
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| Mechanical Properties | |
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| Ceramic and Glass Biomaterials | |
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| Basis of Structure-Property Relationships | |
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| Degradation | |
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| Mechanical Properties | |
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| Polymeric Biomaterials | |
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| Basis of Structure-Property Relationships | |
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| Degradation | |
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| Mechanical Properties | |
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| Choice of Materials for Biomedical Applications | |
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| Biomaterials for Implantable Devices: Present and Future Directions | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions | |
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| Proteins | |
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| Introduction | |
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| Primary Structure | |
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| Secondary Structure | |
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| Tertiary Structure | |
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| Quaternary Structure | |
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| Importance of Conformation | |
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| Examples | |
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| Collagen | |
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| Elastin | |
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| Fibronectin | |
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| Fibrinogen | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions/Discovery Activities | |
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| Protein-Surface Interactions | |
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| Introduction | |
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| Important Protein and Surface Properties | |
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| Protein Properties | |
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| Surface Properties | |
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| Adsorption and Desorption | |
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| Conformational Changes | |
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| Multicomponent Solutions | |
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| Example--Blood-Surface Interactions | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions/Discovery Activities | |
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| Blood-Biomaterial Interactions and Coagulation | |
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| Introduction | |
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| The Blood Cell Source: Marrow and Stem Cells | |
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| Red Blood Cells | |
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| Formation and Function | |
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| Deformation and Blood Flow | |
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| Platelets | |
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| Formation and Function | |
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| Platelet Aggregation and the Process of Coagulation | |
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| The Coagulation Cascades | |
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| Mechanisms | |
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| Control Points | |
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| Anticoagulants and Fibrinolysis | |
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| Biomaterials, Devices, and Thrombosis | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Study Questions | |
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| Discovery Activities | |
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| Inflammation and Infection | |
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| Introduction | |
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| Historical Observations: Inflammation and Infection | |
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| Nonlymphatic Leukocytes | |
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| Inflammation and Leukocyte Functions | |
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| Chemotaxis and Cell Migration | |
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| Phagocytosis | |
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| Diapedesis | |
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| Physiological Explanations for the Cardinal Signs | |
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| Infection | |
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| Summary | |
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| References | |
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| Bibliography/Suggested Reading | |
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| Study Questions | |
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| Discovery Activities | |
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| The Immune System and Inflammation | |
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| Introduction | |
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| Lymphocytes | |
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| Immunogens, Antigens, and Antibodies | |
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| Cell-Mediated Immunity | |
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| T Cell Subpopulations and Functions | |
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| Antigen-Presenting Cells | |
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| Humoral Immunity | |
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| B Cell Subpopulations and Functions | |
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| The Complement System | |
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| Generating Specificity | |
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| Clonal Selection Theory | |
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| "Self" Versus "Non-self"? | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Study Questions | |
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| Discovery Activities | |
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| Wound Healing | |
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| Introduction | |
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| Tissues | |
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| The Biology of Wound Healing of Vascularized Connective Tissue in Adults | |
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| Pertinent Aspects of Hemostasis and Inflammation | |
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| Proliferative and Repair Phase | |
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| Remodeling Phase | |
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| Scar Tissue | |
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| Timing Aspects | |
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| Factors that Affect the Wound Healing Outcome | |
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| An Example of Wound Healing Tissue: Skin | |
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| Chronic Nonhealing Wounds | |
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| Wound Healing Around Implants in Adults | |
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| Complications Related to Wound Healing Around Implants | |
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| Closing Remarks | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions | |
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| Biomaterial Surfaces and the Physiological Environment | |
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| Introduction | |
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| Surface Characterization Methods | |
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| Contact Angle Analysis | |
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| X-Ray Photoelectron Spectroscopy (XPS) | |
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| Fourier Transform Infrared (FTIR) Spectroscopy | |
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| Secondary Ion Mass Spectroscopy (SIMS) | |
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| Scanning Electron Microscopy (SEM) | |
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| Atomic Force Microscopy (AFM) | |
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| Surface Responses to the Wound Healing Process | |
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| Protein Fouling | |
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| Degradation and Dissolution | |
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| Calcification | |
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| Engineering Biomaterial Surfaces | |
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| Morphologic Modifications | |
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| Physicochemical Modifications | |
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| Biological Modifications | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions/Discovery Activities | |
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| Biocompatibility | |
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| Introduction | |
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| Differences between Biological and Synthetic Materials | |
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| Tests Prerequisite to Evaluation of Biocompatibility | |
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| Methods for Testing and Evaluating Biocompatibility | |
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| In Vitro Testing | |
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| Animal Models | |
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| Clinical Trials | |
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| Attempting to Define Biocompatibility | |
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| Concluding Remarks | |
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| Summary | |
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| Bibliography/Suggested Reading | |
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| Quiz Questions | |
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| Study Questions | |
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| Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia | |
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| Replacing Joints and Teeth | |
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| Answers to Quiz Questions | |
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| Glossary | |
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| Index | |