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Process Analytical Technology

ISBN-10: 047072207X

ISBN-13: 9780470722077

Edition: 2nd 2010

Authors: Katherine A. Bakeev

List price: $140.00
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Description:

Process Analytical Technology 2 nd ed. explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the spectroscopist. This second edition cover all the topics that are in the first edition, with additional chapters on process sampling, NMR spectroscopy and fluorescence spectroscopy (tbc). Other chapters cover the key spectroscopic tools, their applications in the chemical and pharmaceutical industries and basic chemometrics.Updated chapters will be revised with additional application examples from a survey of the current literature. The final chapter on future trends reflects the current state of PAT and areas of growth from the perspective of 2007-2008.
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Book details

List price: $140.00
Edition: 2nd
Copyright year: 2010
Publisher: John Wiley & Sons, Limited
Publication date: 4/20/2010
Binding: Hardcover
Pages: 576
Size: 7.75" wide x 10.00" long x 1.25" tall
Weight: 2.794

Preface to the Second Edition
List of Contributors
List of Abbreviations
Overview of Process Analysis and PAT
Introduction
Execution of Process Analysis Projects
Process Instrumentation
Conclusions
Glossary of Acronyms and Terms
Implementation of Process Analytical Technologies
Introduction to Implementation of Process Analytical Technologies (PAT) in the Industrial Setting
Generalized Process Analytics Work Process
Considerations for PAT Implementation in the Pharmaceutical Industry
Conclusions
Process Sampling: Theory of Sampling - the Missing Link in Process Analytical Technologies (PAT)
Introduction
Theory of Sampling - Introduction
Mass Reduction as a Specifi c Sampling Procedure
Fundamental Sampling Principle
Sampling - a Very Practical Issue
Reactors and Vessels - Identical Process Sampling Issues
Heterogeneity Characterization of 1-D lots: Variography
Data Quality - New Insight from the TOS
Validation in Chemometrics and PAT
Summary
UV-visible Spectroscopy for On-line Analysis
Introduction
Theory
Instrumentation
Sample Interface
Implementation
Applications
Detailed Application Notes
Conclusion
Near-infrared Spectroscopy for Process Analytical Technology: Theory, Technology and Implementation
Introduction
Theory of Near-infrared Spectroscopy
Analyser Technologies in the Near-infrared
The Sampling Interface
Practical Examples of Near-infrared Analytical Applications
Conclusion
Infrared Spectroscopy for Process Analytical Applications
Introduction
Practical Aspects of IR Spectroscopy
Instrumentation Design and Technology
Process IR Instrumentation
Applications of Process IR Analyzers
Process IR Analyzers: a Review
Trends and Directions
Raman Spectroscopy
Attractive Features of Raman Spectroscopy
Potential Issues with Raman Spectroscopy
Fundamentals of Raman Spectroscopy
Raman Instrumentation
Quantitative Raman
Applications
Current State of Process Raman Spectroscopy
Near-infrared Chemical Imaging for Product and Process Understanding
The PAT Initiative
The Role of Near-infrared Chemical Imaging (NIR-CI) in the Pharmaceutical Industry
Evolution of NIR Imaging Instrumentation
Chemical Imaging Principles
PAT Applications
Processing Case Study: Estimating 'Abundance' of Sample Components
Processing Case Study: Determining Blend Homogeneity Through Statistical Analysis
Final Thoughts
Acoustic Chemometric Monitoring of Industrial Production Processes
What is Acoustic Chemometrics?
How Acoustic Chemometrics Works
Industrial Production Process Monitoring
Available On-line Acoustic Chemometric Equipment
Discussion
Conclusions
Process NMR Spectroscopy: Technology and On-line Applications
Introduction
NMR Spectroscopy Overview
Process NMR Instrumentation
Postprocessing Methodologies for NMR Data
Advantages and Limitations of NMR as a Process Analytical Technology
On-line and At-line Applications
Current Development and Applications
Conclusions
Fluorescent Sensing and Process Analytical Applications
Introduction
Luminescence Fundamentals
LIF Sensing Fundamentals
LIF Sensing Instrumentation
Luminescent Detection Risks
Process Analytical Technology Applications
Conclusions
Chemometrics in Process Analytical Technology (PAT)
Introduction
Foundations of Chemometrics
Chemometric Methods in PAT
Overfi tting and Model Validation
Outliers
Calibration Strategies in PAT
Sample and Variable Selection in Chemometrics
Troubleshooting/Improving an Existing Method
Calibration Transfer and Instrument Standardization
Chemometric Model Deployment Issues in PAT
People Issues
The Final Word
On-line PAT Applications of Spectroscopy in the Pharmaceutical Industry
Background
Reaction Monitoring
Crystallization
API Drying
Nanomilling
Hot-melt Extrusion
Granulation
Powder Blending
Compression
Coating
Biologics
Cleaning Validation
Conclusions
NIR spectroscopy in Pharmaceutical Analysis: Off-line and At-line PAT Applications
Introduction
Foundation of Qualitative Method Development
Foundation of Quantitative Method Development
Method Validation
Calibration Transfer
Pharmaceutical Applications
Conclusions
Near-infrared Spectroscopy (NIR) as a PAT Tool in the Chemical Industry: Added Value and Implementation Challenges
Introduction
Successful Process Analyzer Implementation
Example Applications
Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing
Introduction
Regulatory Guidance and its Impact on PAT
Going Beyond Process Analyzers Towards Solutions
Emerging Application Areas of PAT
New and Emerging Sensor and Control Technologies
Advances in Sampling: NeSSI
Challenges Ahead
Conclusion
References
Index