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Protein NMR Spectroscopy Practical Techniques and Applications

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ISBN-10: 0470721936

ISBN-13: 9780470721933

Edition: 2011

Authors: Gordon Roberts, Lu-Yun Lian

List price: $80.50
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Book details

List price: $80.50
Copyright year: 2011
Publisher: John Wiley & Sons, Limited
Publication date: 7/22/2011
Binding: Hardcover
Pages: 366
Size: 6.75" wide x 9.50" long x 1.00" tall
Weight: 1.782
Language: English

List of Contributors
Sample Preparation, Data Collection and Processing
Sample Preparation
Data Collection
Data Processing
Isotope Labelling
Production Methods for Isotopically Labelled Proteins
Uniform Isotope Labelling of Proteins
Selective Isotope Labelling of Proteins
Segmental Labelling
SAIL Methods
Concluding Remarks
Resonance Assignments
Resonance Assignment of Unlabelled Proteins
15N-Edited Experiments
Triple Resonance
Side-Chain Assignments
Measurement of Structural Restraints
NOE-Based Distance Restraints
Dihedral Restraints Derived from J-Couplings
Hydrogen Bond Restraints
Orientational Restraints
Chemical Shift Structural Restraints
Solution Scattering Restraints
Calculation of Structures from NMR Restraints
Historical Development
Structure Calculation Algorithms
Automated NOE Assignment
Nonclassical Approaches
Fully Automated Structure Analysis
Paramagnetic Tools in Protein NMR
Types of Restraints
What Metals to Use?
Paramagnetic Probes
Conclusions and Perspective
Structural and Dynamic Information on Ligand Binding
Fundamentals of Exchange Effects on NMR Spectra
Measurement of Equilibrium and Rate Constants
Detecting Binding - NMR Screening
Mechanistic Information
Structural Information
Macromolecular Complexes
Spectral Simplification through Differential Isotope Labelling
Basic NMR Characterisation of Complexes
3D Structure Determination of Macromolecular Protein-Ligand Complexes
Literature Examples
Studying Partially Folded and Intrinsically Disordered Proteins Using NMR Residual Dipolar Couplings
Ensemble Descriptions of Unfolded Proteins
Experimental Techniques for the Characterisation of IDPs
NMR Spectroscopy of Intrinsically Disordered Proteins
Residual Dipolar Couplings