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Preface to the First Edition | |
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Preface to the Third Edition | |
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Introduction | |
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Chapter outline | |
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Historical aspects | |
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Types of toxic substance | |
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Types of exposure | |
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Dose-response relationship | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Disposition of Toxic compounds | |
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Chapter outline | |
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Absorption of toxic compounds | |
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Distribution of toxic compounds | |
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Excretion of toxic compounds | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Metabolism of Foreign Compounds | |
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Chapter outline | |
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Introduction | |
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Factors affecting toxic responses | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Types of Exposure and Response | |
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Chapter outline | |
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Types of exposure | |
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Route of exposure | |
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Types of toxic response | |
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Biomarkers | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Drugs as Toxic Substances | |
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Chapter outline | |
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Introduction | |
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Paracetamol | |
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Aspirin (salicylate) | |
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Hydralazine | |
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Halothane | |
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Debrisoquine | |
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Thalidomide | |
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Drug interactions | |
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Altered responsiveness: glucose-6-phosphate dehydrogenase deficiency | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Industrial Toxicology | |
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Chapter outline | |
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Industrial chemicals | |
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Means of exposure | |
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Toxic effects | |
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Vinyl chloride | |
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Cadmium | |
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Aromatic amines | |
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Asbestos | |
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Legislation | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Food Additives and Contaminants | |
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Chapter outline | |
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Introduction | |
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Tartrazine | |
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Saccharin | |
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Food contaminants | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Pesticides | |
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Chapter outline | |
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Introduction | |
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DDT | |
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Organophosphorus compounds | |
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Paraquat | |
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Fluoroacetate | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Environmental Pollutants | |
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Chapter outline | |
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Introduction | |
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Air pollution | |
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Particulates | |
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Acid rain | |
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Lead pollution | |
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Water pollution | |
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Arsenic | |
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Food chains | |
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Endocrine disruptors | |
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Mercury and methylmercury | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Natural Products | |
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Chapter outline | |
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Plant toxins | |
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Animal toxins | |
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Fungal toxins | |
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Microbial toxins | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Household Products | |
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Chapter outline | |
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Introduction | |
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Carbon monoxide | |
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Antifreeze: ethylene glycol | |
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Cyanide | |
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Alcohol | |
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Glue sniffing and solvent abuse | |
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Antidotes and the treatment of poisoning | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Toxicity Testing and Risk Assessment | |
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Chapter outline | |
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Introduction | |
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Evaluation of toxicity | |
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Acute toxicity tests | |
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Sub-acute toxicity tests | |
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Chronic toxicity tests | |
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Testing in vitro | |
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Risk assessment and interpretation of toxicological data | |
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Conclusions | |
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Summary and learning objectives | |
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Questions | |
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Bibliography | |
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Answers to questions | |
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Glossary | |
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Index | |