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Microbes as parasites | |
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The varieties of microbes | |
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Living inside or outside cells | |
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Systems of classification | |
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The bacteria | |
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Structure | |
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Nutrition | |
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Growth and division | |
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Gene expression | |
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Extrachromosomal elements | |
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Mutation and gene transfer | |
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Survival under adverse conditions | |
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The genomics of medically important bacteria | |
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The viruses | |
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Infection of host cells | |
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Replication | |
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Outcome of viral infection | |
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Major groups of viruses | |
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The fungi | |
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Major groups of disease-causing fungi | |
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The protozoa | |
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The helminths and arthropods | |
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The helminths | |
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The arthropods | |
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Prions | |
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Rogue protein pathogenesis | |
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Development and transmission of prion diseases | |
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Medical problems posed by prion disease | |
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The hostparasite relationship | |
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The normal flora | |
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Symbiotic associations | |
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The characteristics of parasitism | |
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The evolution of parasitism | |
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The innate defenses of the body | |
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Defense against entry into the body | |
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Defenses once the microorganism penetrates the body | |
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Adaptive responses provide a quantum leap in effective defense | |
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The role of antibodies | |
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The role of T lymphocytes | |
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Extracellular attack on large infectious agents | |
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Local defenses at mucosal surfaces | |
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The cellular basis of adaptive immune responses | |
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B and T cell receptors | |
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Clonal expansion of lymphocytes | |
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The role of memory cells | |
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Stimulation of lymphocytes | |
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Cytokines | |
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Regulatory mechanisms | |
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Tolerance mechanisms | |
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Background to the infectious diseases | |
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Hostparasite relationships | |
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Causes of infectious diseases | |
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The biologic response gradient | |
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Entry, exit and transmission | |
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Sites of entry | |
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Exit and transmission | |
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Types of transmission between humans | |
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Transmission from animals | |
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Immune defenses in action | |
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Complement | |
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Acute phase proteins and pattern recognition receptors | |
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Fever | |
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Natural killer cells | |
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Phagocytosis | |
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Cytokines | |
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Antibody-mediated immunity | |
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Cell-medited immunity | |
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Recovery from infection | |
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Spread and replication | |
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Features of surface and systemic infections | |
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Mechanisms of spread through the body | |
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Genetic determinants of spread and replication | |
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Other factors affecting spread and replication | |
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Parasite survival strategies and persistent infections | |
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Parasite survival strategies | |
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Concealment of antigens | |
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Antigenic variation | |
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Immunosuppression | |
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Persistent infections | |
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Pathologic consequences of infection | |
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Pathology caused directly by the microorganism | |
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Pathologic activation of natural immune mechanisms | |
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Pathologic consequences of the immune response | |
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Skin rashes | |
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Viruses and cancer | |
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Introduction to | |
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The Clinical Manifestations of Infection | |
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Upper respiratory tract infections | |
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The common cold | |
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Pharyngitis and tonsillitis | |
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Parotitis | |
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Otitis and sinusitis | |
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Acute epiglottitis | |
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Oral cavity infections | |
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Laryngitis and tracheitis | |
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Diphtheria | |
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Lower respiratory tract infections | |
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Acute infections | |
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Chronic infections | |
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Parasitic infections | |
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Urinary tract infections | |
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Acquisition and etiology | |
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Pathogenesis | |
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Clinical features and complications | |
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Laboratory diagnosis | |
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Treatment | |
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Prevention | |
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Sexually transmitted diseases | |
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STDs and sexual behavior | |
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Syphilis | |
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Gonorrhea | |
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Chlamydial infection | |
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Other causes of inguinal lymphadenopathy | |
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Mycoplasmas and non-gonococcal urethritis | |
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Other causes of vaginitis and urethritis | |
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Genital herpes | |
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Human papillomavirus infection | |
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Human immunodeficiency virus | |
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Opportunistic STDs | |
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Arthropod infesta | |