Phospholipid Metabolism in Apoptosis
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The last few years have witnessed an explosion of both interest and knowledge about apoptosis, the process by which a cell actively commits suicide. It is now well recognised that apoptosis is essential in many aspects of normal development and is required for maintaining tissue homeostasis. The molecular mechanisms of apoptosis are presently unknown and the subject of focused research effort. It is clear that cell membrane structure and properties play an early part in the induction process. There is increasing evidence that the arrangement of polar lipids in the membrane lipid matrix is an important factor coupled with the homeostatic mechanisms responsible for preserving membrane lipid composition and asymmetry. Changes in membrane permeability are also likely to be involved, possibly as a direct consequence of disturbances in the lipid bilayer matrix. The purpose of this volume is to examine the involvement of membrane lipids in early events of apoptosis. In particular, the role of phospholipids in mitochondrial permeability, membrane lipid asymmetry, and sphingolipid and phospholipid signalling processes in early apoptotic events are reviewed by current researchers in these fields.
List price: $249.99
Copyright year: 2002
Publication date: 5/31/2002
Size: 6.25" wide x 9.25" long x 1.25" tall
|Lipid Metabolism and Release of Cytochrome c from Mitochondria|
|Interaction between Cytochrome c and Oxidized Mitochondrial Lipids|
|Plasma Membrane Phospholipid Asymmetry|
|Apoptosis by Phosphatidylserine in Mammalian Cells|
|Phosphatidylserine Peroxidation during Apoptosis|
|Role of Nitric Oxide and Membrane Phospholipid Polyunsaturation in Oxidative Cell Death|
|Oxidized LDL-induced Apoptosis|
|Induction of Apoptosis by Redox-cycling Quinones|
|Apoptosis Induced by Ionizing Radiation|
|Ceramidases in the Regulation of Ceramide Levels and Function|
|Effect of Ceramides on Phospholipid Biosynthesis and Its Implication for Apoptosis|
|Acid Sphingomyelinase-derived Ceramide Signaling in Apoptosis|
|Cellular Signaling by Sphingosine and Sphingosine 1-phosphate|
|Ceramide in Regulation of Apoptosis|
|Lipid Signaling in CD95-mediated Apoptosis|
|Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis|