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Clinical Approach to Infection in the Compromised Host

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ISBN-10: 0306466937

ISBN-13: 9780306466939

Edition: 4th 2002 (Revised)

Authors: Robert H. Rubin, Lowell S. Young

List price: $369.00
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Description:

This highly anticipated Fourth Edition of a well-regarded resource offers in-depth examinations of the latest developments in the management of infections in the immuno-compromised patient. Addressing the explosion of research information and clinical approaches that have emerged since the publication of the third edition, world-renowned experts maintain and enhance the lucid and accessible presentations that made the previous editions so popular. Covering every important aspect of compromised-host infection, this Fourth Edition offers several new features, including: -discussions on infections that result from hematopoietic stem cell transplantation; -the most recent developments in the management and prevention of infection in immunocompromised surgical patients; -a detailed discussion of the management of AIDS; -up-to-date, critical reviews of the current literature; -practical management advice incorporating the latest scientific information; -a variety of perspectives that clarify complex patients care issues faced by the practitioner; -and much more. Clinical Approach to Infection in the Compromised Host, Fourth Edition is an indispensable day-to-day guide for infectious disease specialists, public health researchers and administrators, clinical microbiologists, immunologists, hematologists and oncologists, pediatricians, and primary care practitioners working with immunocompromised patients. In recent years, the care of these individuals is increasingly being accomplished by community based practitioners. This book is ideally suited to fulfill the needs of these physicians, in addition to being an invaluable treatise for the subspecialist.
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Book details

List price: $369.00
Edition: 4th
Copyright year: 2002
Publisher: Springer
Publication date: 10/31/2002
Binding: Hardcover
Pages: 1000
Size: 11.00" wide x 9.00" long x 1.50" tall
Weight: 4.532
Language: English

Introduction
Defects in Host Defense Mechanisms
Colonization
First Line of Defense
Second Line of Defense
Factors that Influence the Quality of Host Defense
Diseases that Affect Host Defense
Immunosuppressive Drugs
Plasmapheresis
Radiation
Attempts to Strengthen Host Defense
References
Mucocutaneous Infections in the Immunocompromised Host
Introduction
Skin as a Barrier to Infection
Types of Skin Infection
Diagnostic Aspects of Skin Infections in the Compromised Patient
Opportunistic Infections by Pathogen
Diagnostic Aspects of Skin Infections in the Compromised Patient
Inflammatory Disorders that Simulate Infection in the Compromised Host
Conclusion
Bibliography
References
Clinical Approach to the Compromised Host with Fever and Pulmonary Infiltrates
The Febrile Pneumonitis Syndrome and Its Importance
Overview of the Infectious Causes of the Febrile Pneumonitis Syndrome in the Immunocompromised Host
Overview of Noninfectious Causes of the Febrile Pneumonitis Syndrome
Radiologic Clues to the Diagnosis of the Febrile Pneumonitis Syndrome
Specific Diagnosis
Superinfection
References
Central Nervous System Infection in the Immunocompromised Host
Introduction
Viral Infections
Bacterial Infections
Fungal Infections
Protozoal Infections
References
Fungal Infections in the Immunocompromised Host
Introduction
Antifungal Prophylaxis in the Immunocompromised Host
Empiric Antifungal Therapy in Neutropenic Patients with Persistent Fever
Candidiasis
Aspergillosis
Zygomycosis
Fusariosis
Cryptococcosis
Histoplasmosis
Coccidioidomycosis
Blastomycosis
Unusual Fungal Pathogens
Antifungal Agents
References
Mycobacterial and Nocardial Diseases in the Compromised Host
Introduction
Microbiologic Classification and Clinical Syndromes
Pathogenesis and Epidemiology
Treatment of Tuberculosis, Drug-Resistant Tuberculosis, and Alternative Antituberculosis Chemotherapy
Nocardiosis
References
Pneumocystis carinii and Parasitic Infections in the Immunocompromised Host
Introduction
Pneumocystis carinii
Toxoplasma gondii
Cryptosporidium Species
Isospora belli
Microsporidia
Strongyloides stercoralis
Entamoeba histolytica and Amebiasis
Primary Amebic Meningoencephalitis
Leishmaniasis
Other Parasitic Diseases of the Immunocompromised Host
References
Viral Hepatitis in the Compromised Host
Introduction
Role of Immunologic Mechanisms in the Pathogenesis of Viral Hepatitis
Viral Hepatitis in the Immunocompromised Host
Prevention
Summary
References
The Herpesviruses
General Characteristics of Herpesviruses
Characteristics of Particular Herpesviruses
References
Morbidity in Compromised Patients Related to Viruses Other than Herpes Group and Hepatitis Viruses
Introduction
DNA Viruses
RNA Viruses
References
Pathogenesis and Clinical Manifestations of HIV-1 Infection
Epidemiology of HIV-1 Infection
Primary HIV-1 Infection
Pathogenesis of HIV-1 Infection
Neurologic Manifestations of HIV-1 Infection
Clinical Manifestations of AIDS Dementia Complex
Cachexia and Wasting in HIV-1 Infection
Metabolic Disturbances
Principles of Antiretroviral Chemotherapy
Primary and Secondary Prophylaxis of Opportunistic Infections in HIV-1-Infected Individuals
References
Infectious Complications in Children with Cancer and Children with Human Immunodeficiency Virus Infection
Introduction
Background
Interface between Cancer and Infections
Perturbations of Host Defense that Contribute to Infection
Fever
Immunizations
Infection Prophylaxis
Use of Growth Factors
Conclusions
References
Infections Complicating Congenital Immunodeficiency Syndromes
Introduction
Aim of Therapy in Congenital Immunodeficiency Diseases
Specific Infections in Immunodeficiency Syndromes
References
Management of Infections in Leukemia and Lymphoma
Introduction
Host Defenses against Infection in Leukemias and Lymphomas
The Role of Infection in Mortality from Leukemia and Lymphomas
Problems with the Interpretation of Fever and Infection Incidence Data in Neutropenic States
Causes of Fever in Leukemia and Lymphoma
Site of Involvement and the Nature of the Microbial Pathogen(s)
Synthesis
Summary of Recommended Therapeutic Strategies
Approach to the Splenectomized Patient
Neutrophil Transfusions in the Treatment and Prophylaxis of Infection
Immunoprophylaxis and Immunotherapy of Infection
References
Infection in Hematopoietic Stem Cell Transplantation
Introduction
Transplantation Techniques
Recovery of Host Defenses
Phases of Infection after HSCT
Phase I: Infections between Conditioning and Engraftment
Phase II: Infections between Engraftment and Day 100
Phase III: After 100 Days
Other Infections
Pretransplant Infectious Disease Considerations
Infection Control Programs and Surveillance
Conclusions and Future Considerations
References
Infection in the Organ Transplant Recipient
Introduction
Risk of Infection in the Organ Transplant Recipient
Timetable of Infection in the Organ Transplant Recipient
Infection Occurring in the First Month Posttransplant
Infection 1 to 6 Months Posttransplant
Infection in Organ Transplant Patients More than 6 Months Posttransplant
Infectious Disease Problems of Particular Importance in the Organ Transplant Patient
Vaccine Use in Organ Transplant Recipients
Summary and Prospects for the Future
References
Surgical Aspects of Infection in the Compromised Host
Introduction
Diagnostic Approach
Preoperative Preparation
Intraoperative Considerations
Postoperative Management
Conclusions
References
Color Plates
Index