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Biology of the Mammary Gland

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ISBN-10: 0306464144

ISBN-13: 9780306464140

Edition: 2002

Authors: Jan A. Mol, Roger A. Clegg

List price: $229.99
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Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.
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Book details

List price: $229.99
Copyright year: 2002
Publisher: Springer
Publication date: 8/31/2000
Binding: Hardcover
Pages: 314
Size: 6.75" wide x 10.00" long x 1.25" tall
Weight: 1.738
Language: English

Fibroblast Growth Factor Signalling and Cyclin D1 Function are Necessary for Normal Mammary Gland Development during Pregnancy
Hepatocyte Growth Factor and Neuregulin in Mammary Gland Cell Morphogenesis
Expression and Localization of Growth Factors during Mammary Gland Development
Involvement of Growth Factors in the Regulation of Pubertal Mammary Growth in Cattle
Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) Potentially Regulates Programmed Cell Death and Plasminogen Activation in the Mammary Gland
Somatostatin and Opioid Receptors in Mammary Tissue
Heparan Sulphate
Progestin-induced Mammary Growth Hormone (GH) Production
Translocation and Action of Polypeptide Hormones within the Nucleus
Mammary Gland Development and the Prolactin Receptor
Paracrine Mechanisms of Mouse Mammary Ductal Growth
Targeting of PKA in Mammary Epithelial Cells
The PEA3 Group of ETS-related Transcription Factors
Transcription Factor NF 1 Expression in Involuting Mammary Gland
The Elf Group of Ets-Related Transcription Factors
The Role of Stat3 in Apoptosis and Mammary Gland Involution
Synergistic and Antagonistic Interactions of Transcription Factors in the Regulation of Milk Protein Gene Expression
Nucleosome Organisation of the [beta]-Lactoglobulin Gene
Chromatin Remodeling in Hormone-Dependent and -Independent Breast Cancer Cell Lines
The Use of Transplanted Mammary Gland to Study Cancer Signalling Pathways
Development of Mammary Gland Requires Normal [beta]1-Integrin Function
Repression of the Putative Tumor Suppressor Gene Bard1 or Expression of Notch4(Int-3) Oncogene Subvert the Morphogenetic Properties of Mammary Epithelial Cells
Oncogene Mediated Signal Transduction in Transgenic Mouse Models of Human Breast Cancer
Caspases: Decoders of Apoptotic Signals During Mammary Involution
The Role of Plasminogen Activator in the Bovine Mammary Gland
Regulation and Nutritional Manipulation of Milk Fat
Effect of Feeding Pattern and Behaviour on Hormonal Changes and Milk Composition
Genetic Polymorphisms in Milk Protein Genes and their Impact on Milk Composition
Mammary Gland Immunology Around Parturition
Cells and Cytokines in Inflammatory Secretions of Bovine Mammary Gland
Immune Surveillance of Mammary Tissue by Phagocytic Cells
Mammary Gland Immunology And Neonate Protection In Pigs
Relationship Between Teat Tissue Immune Defences and Intramammary Infections
Immunological Aspects of Pregnancy-Associated Glycoproteins
Vaccines Against Bovine Mastitis due to Streptococcus uberis Current Status and Future Prospects
Index