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Although there is scientific consensus that genetic factors play a substantial rolein an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked torisk or resilience remain elusive. Understanding how genetic factors contribute to addiction mayrequire focusing on intermediary mechanisms, or intermediate phenotypes, that connect geneticvariation and risk for addiction. This book offers a comprehensive review of thismechanistic-centered approach and the most promising intermediate phenotypes identified in empiricalresearch. The contributors first consider the most established findings in thefield, including variability in drug metabolism, brain electrophysiological profiles, and subjectivereactions to direct drug effects; they go on to review highly promising areas such as expectancies,attentional processing, and behavioral economic variables; and finally, they investigate moreexploratory approaches, including the differential susceptibility hypothesis and epigeneticmodifications. Taken together, the chapters offer a macro-level testing of the hypothesis that thesealternative, mechanistic phenotypes can advance the understanding of genetic influences onaddiction. The book will be of interest to researchers and practitioners in a range of disciplines,including behavioral genetics, psychology, pharmacology, neuroscience, andsociology.Contributors John Acker, Steven R. H. Beach, Gene H.Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, MegGerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison,Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, LeahM. Mayo, Marcus R. Munafò, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker,Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E.Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet deWit