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Genetic Influences on Addiction An Intermediate Phenotype Approach

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ISBN-10: 0262019698

ISBN-13: 9780262019699

Edition: 2014

Authors: James MacKillop, Marcus R. Munaf�

List price: $10.75
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Although there is scientific consensus that genetic factors play a substantial rolein an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked torisk or resilience remain elusive. Understanding how genetic factors contribute to addiction mayrequire focusing on intermediary mechanisms, or intermediate phenotypes, that connect geneticvariation and risk for addiction. This book offers a comprehensive review of thismechanistic-centered approach and the most promising intermediate phenotypes identified in empiricalresearch. The contributors first consider the most established findings in thefield, including variability in drug metabolism, brain electrophysiological profiles, and subjectivereactions to direct drug effects; they go on to review highly promising areas such as expectancies,attentional processing, and behavioral economic variables; and finally, they investigate moreexploratory approaches, including the differential susceptibility hypothesis and epigeneticmodifications. Taken together, the chapters offer a macro-level testing of the hypothesis that thesealternative, mechanistic phenotypes can advance the understanding of genetic influences onaddiction. The book will be of interest to researchers and practitioners in a range of disciplines,including behavioral genetics, psychology, pharmacology, neuroscience, andsociology.Contributors John Acker, Steven R. H. Beach, Gene H.Brody, Angela D. Bryan, Megan J. Chenoweth, Danielle M. Dick, Eske D. Derks, Mary-Anne Enoch, MegGerrard, Frederick X. Gibbons, Thomas E. Gladwin, Mark S. Goldman, Marcus Heilig, Kent E. Hutchison,Hollis C. Karoly, Steven M. Kogan, Man Kit Lei, Susan Luczak, James MacKillop, Renee E. Magnan, LeahM. Mayo, Marcus R. Munafò, Daria Orlowska, Abraham A. Palmer, Danielle Pandika, Clarissa C. Parker,Robert A. Philibert, Lara A. Ray, Richard R. Reich, Ronald L. Simons, Courtney J. Stevens, Rachel E.Thayer, Rachel F. Tyndale, Tamara L. Wall, Reinout W. Wiers, Michael Windle, Harriet deWit
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Book details

List price: $10.75
Copyright year: 2014
Publisher: MIT Press
Publication date: 12/13/2013
Binding: Hardcover
Pages: 352
Size: 7.25" wide x 9.25" long x 1.00" tall
Weight: 1.694

Lane Relyea is Associate Professor and Chair of Art Theory and Practice at Northwestern University and the Editor-in-Chief of Art Journal. His essays and reviews have appeared in such journals as Artforum, Parkett, Frieze, Art in America, and Flash Art.James MacKillop is Associate Professor in the Department of Psychology at the University of Georgia, where he is also Associate Director of the William and Barbara Owens Institute for Behavioral Research, and Adjunct Associate Professor in the Department of Behavioral and Social Sciences at Brown University.

Marcus R. Munaf� is Professor of Biological Psychology at the University of Bristol,UK.