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Infectious Behavior Brain-Immune Connections in Autism, Schizophrenia, and Depression

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ISBN-10: 0262016451

ISBN-13: 9780262016452

Edition: 2011

Authors: Paul H. Patterson

List price: $24.95
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Description:

In Infectious Behavior, neurobiologist Paul Patterson examines the involvement of the immune system in autism, schizophrenia, and major depressive disorder. Although genetic approaches to these diseases have garnered the lion's share of publicity and funding, scientists are uncovering evidence of the important avenues of communication between the brain and the immune system and their involvement in mental illness. Patterson focuses on this brain-immune crosstalk, exploring the possibility that it may help us understand the causes of these common but still mysterious diseases. The heart of this engaging book, accessible to nonscientists, concerns the involvement of the immune systems of the pregnant woman and her fetus, and a consideration of maternal infection as a risk factor for schizophrenia and autism. Patterson reports on research that may shed light on today's autism epidemic. He also outlines the risks and benefits of both maternal and postnatal vaccinations. In the course of his discussion, Patterson offers a short history of immune manipulation in treating mental illness (recounting some frightening but fascinating early experiments) and explains how the immune system influences behavior and how the brain regulates the immune system, looking in particular at stress and depression. He examines the prenatal origins of adult disease and evidence for immune involvement in autism, schizophrenia, and depression. Finally, he describes the promise shown by recent animal experiments that have led to early clinical trials of postnatal and adult treatments for patients with autism and related disorders. For questions for the author, and updates on the various topics covered in the book since its publication, please check the book's website: http://mitpress.mit.edu/infectiousbehavior
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Book details

List price: $24.95
Copyright year: 2011
Publisher: MIT Press
Publication date: 9/9/2011
Binding: Hardcover
Pages: 176
Size: 6.00" wide x 9.50" long x 0.75" tall
Weight: 0.858
Language: English

Paul H. Patterson, a developmental neurobiologist, is Anne P. and Benjamin R. BiagginiProfessor of Biological Sciences at the California Institute of Technology and a Research Professorof Neurological Surgery at the University of Southern California's Keck School of Medicine. He isthe coauthor (with Alan Brown) of The Origins of Schizophrenia.

Acknowledgments
Introduction
Fever and Madness
Brain-Immune Connections, Stress, and Depression
The Battleground of the Fetal-Maternal Environment
Prenatal Origins of Adult Health and Disease
Infections and Behavior
Animal Models of Autism, Schizophrenia, and Depression?
Immune Involvement in Autism, Schizophrenia, and Depression
Pre- and Postnatal Vaccination: Risks and Benefits
Reasons for Optimism
Perspectives
Further Reading
Index