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Molecular Biology of RNA

ISBN-10: 0199288372

ISBN-13: 9780199288373

Edition: 2010

Authors: David Elliott, Michael Ladomery

List price: $42.99
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Description:

For many years, RNA was thought to have something of a supplementary role in genome function - an intermediate in the flow of biological information from gene to protein. In recent years, however, the centrality of RNA as a key player in gene expression has become clear; it is far from being merely a staging post between gene and protein. Instead, new insights into RNA structure and function have revolutionized our view of molecular biology, and the role of RNA in the evolution oflife itself.Molecular Biology of RNA is the first student text to provide a broad survey of RNA structure and function. It leads the reader through the life cycle of an RNA, placing particular emphasis on post-transcriptional events - including post-transcriptional processing and splicing - to reveal how hugely diverse gene products stem from a relatively modest gene pool. It also describes how RNA molecules have a range of biological functions beyond that of the messenger RNA, including roles ascatalysts and regulatory molecules.Throughout the book, descriptions of our current understanding of the field are augmented with examples of pioneer RNA researchers and their key experiments, demonstrating how we have reached our current level of understanding. Further, boxes illustrate the involvement of RNA in the aetiology of human disease, showing how an understanding of the molecular biology of RNA is central to understanding disease processes and their potential treatment.Molecular Biology of RNA is an essential course text for molecular biology students in the 21st century, capturing the excitement of a field that has changed our understanding of genome function forever.Online Resource CentreThe Online Resource Centre to accompany Molecular Biology of RNA features:For registered adopters:Figures from the book in electronic formatFor students:A hyperlinked bibliography of literature articles cited in the text
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Book details

List price: $42.99
Copyright year: 2010
Publisher: Oxford University Press
Publication date: 1/19/2016
Binding: Paperback
Pages: 468
Size: 7.00" wide x 10.00" long x 0.75" tall
Weight: 2.134
Language: English

Introduction: what is post-transcriptional gene regulation?
The versatility of RNA structure
RNA catalysis
The RNA binding proteins
Capping, cleavage and nuclear polyadenylation
Pre-mRNA splicing- Part 1, nuts and bolts
Pre-mRNA splicing- Part 2, the central role of introns and splicing in eukaryotic gene expression
Regulated RNA processing- How pre-mRNAs are decoded by the splicing machinery
Regulated RNA processing- Alternative splicing
pre-mRNA processing in development and disease
Nucleocytoplasmic traffic of mRNAs
Nucleocytoplasmic traffic of noncoding RNAs
mRNA localisation
mRNA translation
mRNA stability and decay
rRNA and tRNA processing
RNA Editing
RNA interference and microRNAs
Long non-coding RNAs
RNA techniques