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Human Genome Epidemiology Building the Evidence for Using Genetic Information to Improve Health and Prevent Disease

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ISBN-10: 0195398440

ISBN-13: 9780195398441

Edition: 2nd 2010

Authors: Muin J. Khoury, Sara R. Bedrosian, Marta Gwinn, John P. A. Ioannidis, Julian P. T. Higgins

List price: $85.00
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Description:

The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving healthand preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specificapplications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find thebook a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.
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Book details

List price: $85.00
Edition: 2nd
Copyright year: 2010
Publisher: Oxford University Press, Incorporated
Publication date: 1/20/2010
Binding: Hardcover
Pages: 704
Size: 6.50" wide x 9.75" long x 1.75" tall
Weight: 2.486
Language: English

Contributors
Fundamentals of Human Genome Epidemiology Revisited
Human Genome Epidemiology: The Road Map Revisited
Principles of Analysis of Germline Genetics
The Public Health Genomics Enterprise
Navigating the Evolving Knowledge of Human Genetic Variation in Health and Disease
Methods and Approaches for Data Collection, Analysis, and Integration
The Global Emergence of Epidemiological Biobanks: Opportunities and Challenges
Case-Control and Cohort Studies in the Age of Genome-wide Associations
The Emergence of Networks in Human Genome Epidemiology: Challenges and Opportunities
Design and Analysis Issues in Genome-wide Association Studies
The Challenge of Assessing Complex Gene-Environment and Gene-Gene Interactions
STrengthening the REporting of Genetic Association Studies (STREGA)-an Extension of the STROBE Statement
Integration of the Evidence on Gene-Disease Associations: Methods of HuGE Reviews
Genome-wide Association Studies, Field Synopses, and the Development of the Knowledge Base on Genetic Variation and Human Diseases
Case Studies: Cumulative Assessment of the Role of Human Genome Variation in Specific Diseases
Colorectal Cancer
Childhood Leukemias
Bladder Cancer
Type 2 Diabetes
Osteoporosis
Preterm Birth
Coronary Heart Disease
Schizophrenia
Applications of Epidemiologic Methods for Using Genetic Information in Medicine and Public Health
Mendelian Randomization: The Contribution of Genetic Epidemiology to Elucidating Environmentally Modifiable Causes of Disease
Evaluation of Predictive Genetic Tests for Common Diseases: Bridging Epidemiological Clinical and Public Health Measures
The Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Initiative: Methods of the EGAPP Working Group
Rapid, Evidence-based Reviews of Genetic Tests
Role of Social and Behavioral Research in Assessing the Utility of Genetic Information
Assessing the Evidence for Clinical Utility in Newborn Screening
The Role of Epidemiology in Assessing the Potential Clinical Impact of Pharmacogenomics
The Human Epigenome and Cancer
The Use of Family History in Public Health Practice: The Epidemiologic View
Case Studies: Assessing the Use of Genetic Information in Practice for Specific Diseases
Cytochrome P450 Testing in the Treatment of Depression
A Rapid-ACCE Review of CYP2C9 and VKORC1 Allele Testing to Inform Warfarin Dosing in Adults at Elevated Risk for Thrombotic Events to Avoid Serious Bleeding
Hereditary Hemochromatosis: Population Screening for Gene Mutations
Index