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Neurologic Complications of Cancer

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ISBN-10: 0195366743

ISBN-13: 9780195366747

Edition: 2nd 2008

Authors: Lisa M. DeAngelis, Jerome B. Posner

List price: $235.00
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Patients with cancer can suffer from a bewildering variety of neurologic signs and symptoms. The neurologic symptoms are often more disabling than the primary cancer. Symptoms including confusion, seizures, pain and paralysis may be a result of either metastases to the nervous system or one of several nonmetastatic complications of cancer. The physician who promptly recognizes neurologic symptoms occurring in a patient with cancer and makes an early diagnosis may prevent the symptoms from becoming permanently disabling or sometimes lethal. This monograph, an update of the first edition published in 1995, is divided into 3 sections. The first classifies the wide variety of disorders that can…    
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Book details

List price: $235.00
Edition: 2nd
Copyright year: 2008
Publisher: Oxford University Press, Incorporated
Publication date: 10/10/2008
Binding: Hardcover
Pages: 656
Size: 10.12" wide x 6.42" long x 1.10" tall
Weight: 4.070
Language: English

Rationale for Neuro-Oncology
Neurologic complications are common
Neurologic complications are increasing
Neurologic complications are serious
Diagnosis is difficult
Treatment helps
Research is essential
Biologic relationship of nervous system to cancer
Classification of Neuro- Oncologic Disorders
Nonmetastatic complications
Vascular disorders
Metabolic and Nutritional disorders
Side Effects of Cancer Treatment
"Remote Effects"-Paraneoplastic Syndromes
Approach to the Patient
Patient with known cancer
Patient without known cancer
Evaluating the Patient
Relevant scales
Pathophysiology Of Nervous System Metastases
Pathophysiology of the Metastatic Process
Transformation and Growth
Vascularization (Angiogenesis)
Intravasation (blood vessels, lymph channels)
Arrest 1st capillary bed e.g. lung, liver, bone
Passage to arterial circulation
Arrest final capillary bed
Tumor Emboli
Growth in CNS
Clinical Considerations Relevant to Nervous System Metastasis
Tumor Size and lymph node involvement
Properties of Metastases
Differences between a Primary Tumor and Its Metastasis
Site of Metastases
Hemodynamic hypothesis-relevance to nervous system metastases
Seed and soil hypothesis- relevance to nervous system metastases
Timing of Metastases
The Cascade Process
Pathophysiologic Factors Relevant to Spread and Growth of Cancer to Specific Neural Structures
Spinal Cord
Vertebral metastases
Foraminal invasion
Epidural metastases
Consequences of spinal cord compression
Cranial and Peripheral Nerves
Blood-Nervous System Barrier Dysfunction: Pathophysiology And Treatment
Anatomy And Physiology
Blood-Brain Barrier
Blood-Peripheral Nerve Barrier
Blood-Cerebrospinal Fluid Barrier
Disruption Of Blood-Central Nervous System Barriers
Brain Edema
Other Sources of Disruption
Other Substances Causing Blood-Brain Barrier Breakdown
Consequences of Blood-Brain Barrier Disruption: Increased Intracranial
Pressure, Plateau Waves, and Cerebral Herniation
Treatment of Cerebral Herniation
Transport of Chemotherapeutic Drugs Across the Blood-Brain Barrier
Restoration of Blood-Central Nervous System Barriers
Lowering Intracranial Pressure
Brain metastases
Spinal cord compression
Corticosteroids for other neurologic complications of cancer
Corticosteroid taper
Mechanisms of corticosteroid action on blood-brain barrier
Supportive Care and Its Complications
Salutary effects of corticosteroids
Unwanted side effects of corticosteroids
Behavioral/Cognitive Side-Effects
Bone Disorders
Visual Problems
Gastrointestinal Disorders
Bowel Perforation
Pneumatosis Cystoides Intestinalis
Colonic Ileus<br