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| Introduction | |
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| Rationale for Neuro-Oncology | |
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| Neurologic complications are common | |
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| Neurologic complications are increasing | |
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| Neurologic complications are serious | |
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| Diagnosis is difficult | |
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| Treatment helps | |
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| Research is essential | |
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| Biologic relationship of nervous system to cancer | |
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| Classification of Neuro- Oncologic Disorders | |
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| Metastases | |
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| Nonmetastatic complications | |
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| Vascular disorders | |
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| Infections | |
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| Metabolic and Nutritional disorders | |
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| Side Effects of Cancer Treatment | |
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| "Remote Effects"-Paraneoplastic Syndromes | |
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| Approach to the Patient | |
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| Patient with known cancer | |
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| Patient without known cancer | |
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| Evaluating the Patient | |
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| Relevant scales | |
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| Pathophysiology Of Nervous System Metastases | |
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| Introduction | |
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| Pathophysiology of the Metastatic Process | |
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| Transformation and Growth | |
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| Vascularization (Angiogenesis) | |
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| Invasion | |
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| Intravasation (blood vessels, lymph channels) | |
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| Circulation | |
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| Arrest 1st capillary bed e.g. lung, liver, bone | |
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| Passage to arterial circulation | |
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| Arrest final capillary bed | |
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| Tumor Emboli | |
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| Extravasation | |
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| Dormancy | |
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| Growth in CNS | |
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| Clinical Considerations Relevant to Nervous System Metastasis | |
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| Tumor Size and lymph node involvement | |
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| Properties of Metastases | |
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| Differences between a Primary Tumor and Its Metastasis | |
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| Site of Metastases | |
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| Hemodynamic hypothesis-relevance to nervous system metastases | |
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| Seed and soil hypothesis- relevance to nervous system metastases | |
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| Subtypes | |
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| Timing of Metastases | |
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| The Cascade Process | |
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| Pathophysiologic Factors Relevant to Spread and Growth of Cancer to Specific Neural Structures | |
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| Brain | |
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| Spinal Cord | |
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| Vertebral metastases | |
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| Foraminal invasion | |
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| Epidural metastases | |
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| Consequences of spinal cord compression | |
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| Leptomeninges | |
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| Cranial and Peripheral Nerves | |
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| Blood-Nervous System Barrier Dysfunction: Pathophysiology And Treatment | |
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| Introduction | |
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| Anatomy And Physiology | |
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| Blood-Brain Barrier | |
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| Blood-Peripheral Nerve Barrier | |
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| Blood-Cerebrospinal Fluid Barrier | |
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| Disruption Of Blood-Central Nervous System Barriers | |
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| Brain Edema | |
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| Other Sources of Disruption | |
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| Other Substances Causing Blood-Brain Barrier Breakdown | |
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| Consequences of Blood-Brain Barrier Disruption: Increased Intracranial | |
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| Pressure, Plateau Waves, and Cerebral Herniation | |
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| Treatment of Cerebral Herniation | |
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| Transport of Chemotherapeutic Drugs Across the Blood-Brain Barrier | |
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| Restoration of Blood-Central Nervous System Barriers | |
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| Lowering Intracranial Pressure | |
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| Corticosteroids | |
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| Brain metastases | |
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| Spinal cord compression | |
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| Corticosteroids for other neurologic complications of cancer | |
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| Corticosteroid taper | |
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| Mechanisms of corticosteroid action on blood-brain barrier | |
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| Supportive Care and Its Complications | |
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| Introduction | |
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| Edema/Glucocorticoids | |
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| Salutary effects of corticosteroids | |
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| Unwanted side effects of corticosteroids | |
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| Myopathy | |
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| Behavioral/Cognitive Side-Effects | |
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| Insomnia | |
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| Hyperglycemia | |
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| Bone Disorders | |
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| Lipomatosis | |
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| Visual Problems | |
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| Gastrointestinal Disorders | |
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| Ulceration | |
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| Bowel Perforation | |
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| Pneumatosis Cystoides Intestinalis | |
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| Colonic Ileus<br | |