| |
| |
Introduction | |
| |
| |
The aim of this book | |
| |
| |
How to use this book | |
| |
| |
| |
Basic Concepts And Procedures | |
| |
| |
| |
Introduction | |
| |
| |
| |
Determining what the facts are | |
| |
| |
Summarizing the facts | |
| |
| |
| |
Absolute and relative differences | |
| |
| |
| |
Diagrams | |
| |
| |
| |
Seeking explanations for the facts | |
| |
| |
Testing explanations | |
| |
| |
| |
The basic scientific process | |
| |
| |
Rates | |
| |
| |
| |
Rates (continued) | |
| |
| |
Inspecting a two-dimensional table | |
| |
| |
| |
Inspecting a two-dimensional table (continued) | |
| |
| |
| |
Inspecting a two-dimensional table (continued) | |
| |
| |
Associations | |
| |
| |
| |
Associations (continued) | |
| |
| |
Confounding | |
| |
| |
| |
Confounding (continued) | |
| |
| |
Effect modification | |
| |
| |
| |
Refinement | |
| |
| |
Skeleton tables | |
| |
| |
Elaborating an association | |
| |
| |
| |
Modifying and confounding effects | |
| |
| |
| |
Elaborating an association (continued) | |
| |
| |
| |
The use of rates | |
| |
| |
Causal explanations | |
| |
| |
Testing causal explanations | |
| |
| |
| |
Testing causal explanations (continued) | |
| |
| |
Basic procedure for appraisal of data | |
| |
| |
What are the facts? | |
| |
| |
What are the possible explanations? | |
| |
| |
What additional information is required? | |
| |
| |
| |
Uses of epidemiological data | |
| |
| |
| |
Test Yourself (A) | |
| |
| |
| |
Rates And Other Measures | |
| |
| |
| |
Introduction | |
| |
| |
What is a rate? | |
| |
| |
Prevalence rates | |
| |
| |
| |
Prevalence rates (continued) | |
| |
| |
Questions about a rate | |
| |
| |
What kind of rate is it? | |
| |
| |
Of what is it a rate? | |
| |
| |
To what population or group does the rate refer? | |
| |
| |
How was the information obtained? | |
| |
| |
| |
Sources of bias | |
| |
| |
Confidence interval | |
| |
| |
Validity | |
| |
| |
Qualitative studies | |
| |
| |
| |
Use of prevalence data | |
| |
| |
Incidence rates | |
| |
| |
| |
Incidence rates (continued) | |
| |
| |
| |
Bias in incidence studies | |
| |
| |
| |
Uses of incidence rates | |
| |
| |
| |
Estimating the individual's chances | |
| |
| |
Time to event (survival time) | |
| |
| |
| |
Estimating the individual's chances (continued) | |
| |
| |
Other rates | |
| |
| |
What are the odds? | |
| |
| |
| |
Other rates (continued) | |
| |
| |
Odds ratio | |
| |
| |
| |
Other measures | |
| |
| |
| |
Indirect standardization | |
| |
| |
| |
Indirect standardization (continued) | |
| |
| |
Direct Standardization | |
| |
| |
| |
The use of standardized rates | |
| |
| |
| |
Test Yourself (B) | |
| |
| |
| |
How Good Are The Measures? | |
| |
| |
| |
Introduction | |
| |
| |
| |
Validity of a measure | |
| |
| |
Sensitivity and specificity | |
| |
| |
| |
Misclassification | |
| |
| |
| |
Differential misclassification | |
| |
| |
| |
Effects of misclassification | |
| |
| |
| |
Effects of misclassification (continued) | |
| |
| |
| |
Other ways of appraising validity | |
| |
| |
Reliability | |
| |
| |
| |
Appraisal of reliability | |
| |
| |
| |
Appraisal of reliability (continued) | |
| |
| |
Regression toward the mean | |
| |
| |
Taking account of validity and reliability | |
| |
| |
Screening tests | |
| |
| |
| |
Appraisal of a screening test | |
| |
| |
| |
Appraisal of a screening test (continued) | |
| |
| |
| |
Appraisal of diagnostic tests | |
| |
| |
ROC curves | |
| |
| |
The meaning of ""normal"" | |
| |
| |
| |
Test Yourself (C) | |
| |
| |
| |
Making Sense Of Associations | |
| |
| |
| |
Introduction | |
| |
| |
| |
Explanations for an association | |
| |
| |
| |
Effects of misclassification | |
| |
| |
Statistical significance | |
| |
| |
| |
Statistical significance (continued) | |
| |
| |
| |
Confounding effects | |
| |
| |
| |
Confounding effects (continued) | |
| |
| |
| |
Multivariate analysis | |
| |
| |
| |
Explanations for the findings | |
| |
| |
Risk factors and risk markers | |
| |
| |
Appraising a risk marker | |
| |
| |
Uses of the findings | |
| |
| |
| |
Risk factors and risk markers (continued) | |
| |
| |
Measures of the strength of an association | |
| |
| |
| |
Measures of strength | |
| |
| |
| |
Measures of strength (continued) | |
| |
| |
Matched samples | |
| |
| |
| |
Synergism | |
| |
| |
| |
Appraising stratified data | |
| |
| |
Making sense of a multivariate analysis | |
| |
| |
| |
Multiple logistic regression | |
| |
| |
| |
Multiple logistic regression (continued) | |
| |
| |
| |
Proportional hazards regression | |
| |
| |
| |
Multiple linear regression | |
| |
| |
| |
Test Yourself (D) | |
| |
| |
| |
Causes And Effects | |
| |
| |
| |
Introduction | |
| |
| |
Kinds of study | |
| |
| |
| |
Appraising the results of a cross-sectional study | |
| |
| |
| |
Appraising the results of a case-control study | |
| |
| |
| |
Appraising the results of a cohort study | |
| |
| |
| |
Appraising the results of a group-based study | |
| |
| |
| |
Appraising the results of an experiment | |
| |
| |
| |
Appraising the results of a quasi-experiment | |
| |
| |
| |
Artifact, confound or cause? | |
| |
| |
| |
Coping with confounding | |
| |
| |
Delving into causes | |
| |
| |
| |
Evidence for a causal relationship | |
| |
| |
| |
Evidence for a causal relationship (continued) | |
| |
| |
| |
mpact of a causal factor | |
| |
| |
| |
The attributable fraction | |
| |
| |
| |
Prevented and preventable fractions | |
| |
| |
| |
Test Yourself (E) | |
| |
| |
| |
Meta-Analysis: Putting It All Together | |
| |
| |
| |
Introduction | |
| |
| |
| |
The scope of meta-analysis | |
| |
| |
| |
Measures used in meta-analysis | |
| |
| |
| |
Measures used in meta-analysis (continued) | |
| |
| |
Basic information | |
| |
| |
| |
Finding the studies | |
| |
| |
| |
Selecting studies | |
| |
| |
| |
The quality of the studies | |
| |
| |
Extracting the findings | |
| |
| |
Apples and oranges | |
| |
| |
| |
Appraising combinability | |
| |
| |
Explaining heterogeneity | |
| |
| |
| |
Explaining heterogeneity (continued) | |
| |
| |
| |
Effect modification | |
| |
| |
| |
Using the results | |
| |
| |
Evaluating a meta-analysis | |
| |
| |
F12 | |
| |
| |
| |
Putting Study Findings To Use | |
| |
| |
| |
Introduction | |
| |
| |
| |
Are the results accurately known? | |
| |
| |
| |
Validity of the findings | |
| |
| |
| |
Relevance of the findings | |
| |
| |
| |
Expected effects | |
| |
| |
| |
Feasibility and cost | |
| |
| |
| |
Test Yourself (G) | |
| |
| |
References | |
| |
| |
Index | |