Psychiatric Epidemiology Searching for the Causes of Mental Disorders

ISBN-10: 0195101812

ISBN-13: 9780195101812

Edition: 2006

Authors: Evelyn J. Bromet, Alfredo Morabia, Sharon Schwartz, Ezra Susser, Melissa D. Begg

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Description:

Searching for the causes of mental disorders is as exciting as it it complex. The relationship between pathophysiology and its overt manifestations is exceedingly intricate, and often the causes of a disorder are elusive at best. This book is an invaluable resource for anyone trying to track these causes, whether they be clinical researchers, public health practitioners, or psychiatric epidemiologists-in-training. Uniting theory and practice in very clear language, it makes a wonderful contribution to both epidemiologic and psychiatric research. Rather than attempting to review the descriptive epidemiology of mental disorders, this book gives much more dynamic exposition of the thinking and techniques used to establish it. Starting out by tracing the brief history of psychiatric epidemiology, the book describes the study of risk factors as causes of mental disorders. Subsequent sections discuss approaches to investigation of biologic, genetic, or social causes and the statistical analysis of study results. The book concludes by following some of the problems involved in the search for genetic causes of mental disorders, and more complex casual relationships.
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Book details

List price: $79.00
Copyright year: 2006
Publisher: Oxford University Press, Incorporated
Publication date: 6/1/2006
Binding: Hardcover
Pages: 544
Size: 7.25" wide x 10.25" long x 1.50" tall
Weight: 2.486
Language: English

Foreword
Contributors
Psychiatric Epidemiology, Then and Now
The Burden of Mental Illness
The Arc of Epidemiology
Searching for the Causes of Mental Disorders
Risk Factors as Causes of Mental Disorders
What Is a Cause?
Detecting Causes
Study Designs
Relationships among Causes
Measures of Association
Cohort Designs in Psychiatric Epidemiology
Prototypical Cohort Study
Diversity of Cohort Studies
Causal Inference: A Thought Experiment
Confounding: What It Is and What Can Be Done
Unequal Attrition under Different Types of Follow-Up
Differential Misclassification
Case-Control Designs in Psychiatric Epidemiology
Logic of the Case-Control Design
Applications of the Case-Control Study
Choosing Controls
Comparability and the Case-Control Study
Case-Control Designs in Biologic Psychiatry
Biologic Studies in Psychiatry
Choosing Cases in Biologic Psychiatry
Choosing Controls in Biologic Psychiatry
Analyzing the Data
Gauging the Precision of Measures of Association
Using Significance Tests in Establishing Associations
Planning Studies: Estimating Power and Sample Size
Adjustment for Covariates
Event Time Analysis
Assessing Heterogeneity of Effects
The Search for Genetic Causes of Mental Disorders
Integrating Epidemiology with Genetics
Genetic Association Studies
Modern Family History Studies
Twin Studies of Heritability
Genetic Linkage Studies
Designs for the Genomic Era
Complex Causal Relationships
Eco-Epidemiology
Causal Explanation within a Risk Factor Framework
Causal Explanation Outside the Black Box
Dependent and Dynamic Processes
Our Approach to Epidemiologic Concepts and Methods
Application of Survival Analysis to Prenatal Determinants of Schizophrenia Example (PDSE) Data
Glossary
Index
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