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Introductory material | |
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Introduction | |
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Historical perspective | |
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The aim and structure of this book | |
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Drug administration and drug effectiveness | |
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The state of the art | |
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Two views of the future | |
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Summary | |
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Fundamentals | |
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Diffusion and drug dispersion | |
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Random walks | |
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Equations for the diffusive flux (Fick's law) | |
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Equations of mass conservation (Fick's second law) | |
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Solutions to the diffusion equation with no solute elimination or generation | |
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Solutions to the diffusion equation with solute binding and elimination | |
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A few applications | |
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Summary | |
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Diffusion in biological systems | |
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Measurement of diffusion coefficients | |
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Diffusion in water | |
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Diffusion in polymer solutions and gels | |
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Diffusion in the extracellular space | |
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Diffusion with binding in tissues | |
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Diffusion within cells | |
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Diffusion and reaction | |
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Summary | |
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Drug permeation through biological barriers | |
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Mobility of lipids and proteins in the membrane | |
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Permeation through lipid membranes | |
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Permeation through porous membranes | |
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Permeation is enhanced by membrane proteins | |
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Permeation through cell layers | |
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Summary | |
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Drug transport by fluid motion | |
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Blood movement in the circulatory system | |
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Interstitial fluid movement | |
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Fluid movement in the lymphatic circulation | |
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Fluid movement in the brain | |
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Summary | |
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Pharmacokinetics of drug distribution | |
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Compartmental models | |
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Physiological models | |
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Patterns of mixing in tissues and organs | |
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The problem of scale | |
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Summary | |
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Drug delivery systems | |
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Drug modification | |
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Enhancing agent solubility | |
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Enhancing agent stability | |
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Regulating agent permeability | |
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Drug targeting and drug valency | |
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Summary | |
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Controlled drug delivery systems | |
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Reservoir and transdermal delivery systems | |
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Matrix delivery systems | |
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Hydrogel delivery systems | |
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Degradable delivery systems | |
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Particulate delivery systems | |
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Responsive delivery systems | |
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Summary | |
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Case studies in drug delivery | |
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Controlled delivery of systemic therapy | |
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Implants for local drug delivery | |
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Topically applied devices for controlled release | |
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Postscript | |
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Overview of polymeric biomaterials | |
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Non-degradable polymers | |
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Silicone elastomers | |
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Poly[ethylene-co-(vinyl acetate)] | |
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Polyurethanes | |
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Other important polymers | |
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Biodegradable polymers | |
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Polyesters | |
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Copolymers of methyl vinyl ether and maleic anhydride | |
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Poly(ortho esters) | |
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Polyanhydrides | |
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Poly(amino acids) | |
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Phosphorus-containing polymers | |
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Polycarbonates and poly(iminocarbonates) | |
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Polydioxanone | |
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Water-soluble polymers | |
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Naturally occurring polymers | |
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Acrylates and acrylamides | |
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Poly(ethylene glycol) | |
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Useful data and nomenclature | |
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Physiological parameters | |
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Cardiovascular system | |
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Clinical chemistry | |
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Permeation and diffusion | |
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Protein properties | |
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Mathematical tables and functions | |
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Nomenclature | |
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Index | |