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Introduction to Biological and Small Molecule Drug Research and Development Theory and Case Studies

ISBN-10: 0123971764

ISBN-13: 9780123971760

Edition: 2013

Authors: C. Robin Ganellin, Stanley Roberts, Roy Jefferis

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The fundamental concept of the book is to provide, for the first time, an introduction to understand the science behind successful pharmaceutical research and development programs. As well as explaining the basic principles, the book compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs and presents an overview of the business and management issues for these approaches. The second part of the book provides 9 carefully selected real life case studies to illustrate how the theory presented in the first part of the book is actually being put into practice. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine or allied subjects. The book would be used as part of the reading matter for a wide variety of science degree courses, in post-graduate taught material (Masters and PhD) and as basic background reading for scientists in the pharmaceutical industry. . For the first time the fundamental principles of the science of biopharmaceutics and small molecule chemotherapeutics are discussed side-by-side at a basic level . Edited by three senior scientists with over 100 years experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs . The book will be of broad interest to students of medicine, pharmacy, biochemistry and chemistry who wish to learn about drug discovery . Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development
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Book details

Copyright year: 2013
Publisher: Elsevier
Publication date: 5/29/2013
Binding: Hardcover
Pages: 472
Size: 7.80" wide x 9.50" long x 1.00" tall
Weight: 2.442
Language: English

Janos Fischer is research laboratory head at Richter Ltd. (Budapest, Hungary). He received his education in Hungary with B.Sc. and P.h. D. degrees in organic chemistry at the Eotvos University of Budapest with Professor A. Kucsman. Between 1976-78 he was a Humboldt fellow at the University of Bonn with Professor W. Steglich. He has worked at Richter Ltd. since 1981 where he participated in the research and development of leading cardiovascular drugs in Hungary. His main interest now is analog-based drug discovery. He is author of some 100 patents and scientific publications. In 2004 he was elected member of the Chemistry and Human Health Division of IUPAC. Robin Ganellin studied Chemistry at London University, receiving a PhD in 1958 under Professor Michael Dewar, and was a Research Associate at MIT with Arthur Cope in 1960. He then joined Smith Kline & French Laboratories in the UK and was one of the co-inventors of the revolutionary drug cimetidine (also known as Tagamet). In 1986 he was made a Fellow of the Royal Society and appointed to the SK&F Chair of Medicinal Chemistry at University College London, where he is now Emeritus Professor of Medicinal Chemistry. Professor Ganellin is co-inventor on over 160 patents and has authored 250 scientific publications. He was President of the Medicinal Chemistry Section of IUPAC and is currently Chairman of the IUPAC Subcommittee on Medicinal Chemistry and Drug Development.