Rabies Scientific Basis of the Disease and Its Management

Name: Rabies Scientific Basis of the Disease and Its Management
Price: 11.99 USD
Availability: InStock
ISBN: 9780123965479

ISBN-10: 0123965470

ISBN-13: 9780123965479

Edition: 3rd 2013

Authors: Alan C. Jackson

List price: $104.00

30 day, 100% satisfaction guarantee!

Marketplace

2 new & used from $11.99

what's this?

Rush Rewards U
Members Receive:

You have reached 400 XP and carrot coins. That is the daily max!

Description:

Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this ancient disease, rabies has become a re-emergent infection in the developing world. The third edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, vaccines, public health, immunology, and epidemiology of rabies. Chapters new to this edition cover biothreat/bioterrorism, successful wildlife control and therapies of human rabies, and the emergence of new lyssavirus species Rabies provides physicians, public health advisors, epidemiologists, research scientists and…

Book details

List price: $104.00
Edition: 3rd
Copyright year: 2013
Publisher: Elsevier Science & Technology
Publication date: 5/21/2013
Binding: Hardcover
Pages: 704
Size: 5.94" wide x 9.00" long x 1.75" tall
Weight: 3.630
Language: English



Preface


Foreword


List of Contributors



History of Rabies Research




Ancient Greek and Roman times



Girolamo Fracastoro



John Morgagni



Earliest Pathogenesis Studies



Louis Pasteur and Rabies Vaccination



Earliest Pathogenesis Studies Focused on Pathways of Neural Spread to CNS



Adelchi Negri and Negri bodies



Paul Remlinger



Early Studies Using Electron Microscopy



Fluorescent Antibody Staining by Goldwasser and Kissling



Pathogenesis Studies in Rodents by Richard T. Johnson and Frederick A. Murphy and Co-workers



First Clone of a Rabies Virus Gene


References



Rabies Virus




Introduction



Rabies Virus Architecture



Genome and RNP Structures



Life Cycle of Rabies Virus Infection


References



Epidemiology




Introduction



Global Epidemiology



Routes Of Rabies Virus Transmission



Risk and Prevention of Rabies Following an Exposure



Epidemiology of Human Rabies in North America and Europe



Epidemiology of Human Rabies in Africa and Asia



The Burden and Cost of Rabies in Africa and Asia



Epizootiology of Rabies in Latin America



Case Number Dynamics and Modeling



Skunk Rabies Virus Variants



Raccoon Rabies in North America



Epidemiology of Mongoose-associated Rabies



Canine Rabies Virus Variants



Conclusions


References



Molecular Epidemiology




Introduction



Methods and Definition of Terms



Lyssavirus Taxonomy



Future Trends



Conclusions


Acknowledgements


References



Rabies in Terrestrial Animals




Introduction



What is a Susceptible Host?



Pathogenesis



Prevention



Clinical Signs



Domestic Dogs



Raccoons



Skunks



Mongooses and Their Allies



Foxes



Coyotes



Jackals



Wolves



Cats



Cattle



Horses and Donkeys



Sheep and Goats



Opossums and Other Marsupials



Rodents and Lagomorphs



Other Species



Conclusions


References



Bat Rabies




Introduction



Lyssaviruses and Insectivorous Bats



Lyssaviruses and Frugivorous Bats



Rabies in Hematophagous Bats



Conclusions


Acknowledgements


References



Human Disease




Introduction



Exposures, Incubation Period, and Prodromal Symptoms



Clinical Forms of Disease



Investigations



Differential Diagnosis



Rabies Due to Other Lyssavirus Genotypes


References



Pathogenesis




Introduction



Virus Entry into the Nervous System



Rabies Virus Receptors



Spread to the CNS



Spread within the CNS



Spread from the CNS



Animal Models of Rabies Virus Neurovirulence



Structural Damage Caused by Rabies Virus Infection in the CNS



Brain Dysfunction in Rabies



Recovery from Rabies and Chronic Rabies Virus Infection



Summary


References



Pathology




Introduction



Macroscopic Findings



Pathology in the Central Nervous System



Pathology in the Peripheral Nervous System



Pathology Involving the Inoculation Site, Eye, and Extraneural Organs



Summary and Conclusions


References



Immunology




Introduction



RABV Innate Immune Response



RABV Adaptive Immune Response



RABV Infection Triggers a CNS Mediated Immune-Unresponsiveness



Paradoxical Role of IFN in RABV Virulence



Conclusions


References



Laboratory Diagnosis of Rabies




Laboratory-Based Rabies Diagnostic Testing



Postmortem Diagnosis of Rabies in Animals



Antemortem Diagnosis of Rabies



Use of Molecular Methods to Detect Viral RNA



Conclusions


References



Measures of Rabies Immunity




Introduction



History of Regulatory Standards



Regulatory Requirements



Assuring Quality Results



Assay Selection



Serum Neutralization Assays



Binding Assays



Defining "Adequate" or "Minimum" Response to Rabies Vaccination



Conclusions


References



Rabies Vaccines




Introduction



Human and Animal Rabies Vaccines


Acknowledgements


References



Next Generation of Rabies Vaccines




Introduction



History of Rabies Vaccines



Current Rabies Vaccine Regimens



Incidence and Risk for Rabies and Vaccine Failures



Correlates of Protection



Experimental Vaccines for Rabies



Summary


References



Public Health Management of Humans at Risk




Introduction



Human Deaths are Preventable



Factors Responsible for the Continuation of Human Rabies Deaths



Tools to Prevent Human Rabies Deaths



Communication, Awareness, and Advocacy



Involving Communities in Rabies Control Efforts



Sustainability



Conclusions


References



Therapy of Human Rabies




Human Cases with Recovery from Rabies



Future Prospects for the Aggressive Management of Rabies in Humans


References



Dog Rabies and Its Control




Introduction



Epidemiological Theory of Dog Rabies Control



Practical Aspects of Dog Rabies Control


References



Rabies Control in Wild Carnivores




Introduction



Historical and Contemporary Aspects of Rabies Control in Wildlife



The Concept of Controlling Rabies in Wildlife



Initiation of Wildlife Rabies Control Programs



Diagnosis of Suspect Wildlife



Vector Species Biology in Relation to Rabies Epidemiology



Transportation of Wildlife



Point Infection Control



Percentage of a Vector Population that has to be Culled or Immunized in order to Control Rabies



Bait Development for Delivery of Oral Rabies Vaccine



Oral Rabies Vaccination Initiation/Considerations



Importance of Rabies Vector Ecology for Rabies Control Planning



Large-Scale Vaccine-Bait Distribution Technology



Surveillance Prior to, During, and After a Rabies Control Program



The Ontario Rabies Management Program-A Model of a Multi-Faceted Approach to Wildlife Rabies Control



The Costs and Benefits of Wildlife Rabies Control



Vaccine Baiting Efficiency and Baiting Success Guidelines



Modeling



Contingency Planning



Conclusions


Acknowledgements


References



Blueprint for Rabies Prevention and Control




Introduction



Principles and Format



Steps Required for Canine Rabies Elimination



Conclusions and Future Developments


Acknowledgements


References



Future Developments and Challenges




Introduction



Pathogenesis



Epidemiology



Therapy of Human Rabies



Rabies Virus as a Biothreat Agent



Prevention of Human Rabies



Control of Animal Rabies


References


Index