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| Contributors | |
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| Acknowledgments | |
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| Preface | |
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| Foreword | |
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| Autism: Neuropathology, Alterations of the GABAergic System, and Animal Models | |
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| Introduction | |
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| Neuropathologic Alterations in Specific Brain Regions in Autism | |
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| GABAergic Abnormalities in Autism | |
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| GABA and Brain Development | |
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| Animal Models of Autism | |
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| Discussion | |
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| References | |
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| The Role of GABA in the Early Neuronal Development | |
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| Introduction | |
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| The GABA Signaling System in the Developing CNS | |
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| GABA as a Developmental Signal | |
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| Concluding Remarks | |
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| References | |
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| GABAergic Signaling in the Developing Cerebeilum | |
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| Introduction | |
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| GABAergic System in the Cerebellar Cortex | |
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| GABAergic Signaling Before Synaptogenesis | |
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| Formation of GABAergic Synapses | |
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| Functions of GABAergic Synapses in the Cerebellum | |
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| References | |
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| Insights into GABA Functions in the Developing Cerebellum | |
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| Introduction | |
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| The Adult Cerebellum | |
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| The Developing Cerebellum | |
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| GABA[subscript A] Receptors and the Developing Cerebellum | |
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| Depolarization and Neurotrophins Are Trophic Signals | |
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| Establishing an In Vitro Model to Study the Developing Cerebellar Granule Neurons | |
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| GABA-Mediated Depolarization and Calcium Increases | |
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| Intracellular Pathways Activated Downstream GABA[subscript A] Receptors | |
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| References | |
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| Role of GABA in the Mechanism of the Onset of Puberty in Non-Human Primates | |
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| Introduction | |
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| Developmental Changes in Luteinizing Hormone-Releasing Hormone Release | |
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| Developmental Changes in GABA Release | |
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| Evidence for GABA as an Inhibitory Neurotransmitter Before Puberty | |
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| Interference of Glutamic Acid Decarboxylase in Puberty | |
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| Other Possible Factors Associated with Developmental Changes in GABAergic Function | |
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| The Pubertal Reduction in GABAergic Inhibition is Followed by an Increase in Glutamatergic Tone | |
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| Conclusions | |
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| References | |
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| Rett Syndrome: A Rosetta Stone for Understanding the Molecular Pathogenesis of Autism | |
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| Overlapping Syndromes: Rett Syndrome, Angelman Syndrome, and Autism | |
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| The 15q11-13 Imprinted Gene Cluster | |
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| MeCP2: A "Rosetta Stone" for Autism? | |
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| GABRB3 Expression in Normal Development and Autism | |
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| The Dynamics of Chromatin and Nuclear Organization within the Maturing Neuron | |
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| A Higher Order Model for MeCP2 in Regulating Gene Expression within 15q11-13 | |
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| Future Directions and Remaining Questions | |
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| References | |
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| GABAergic Cerebellar System in Autism: A Neuropathological and Developmental Perspective | |
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| Introduction | |
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| The GABAergic System in the Cerebellum in Autism | |
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| Functional Consequences of Altered Cerebellar Function in Autism | |
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| Future and Ongoing Neuropathological Experiments to Further Understand How Cerebellar Circuitry is Altered in Autism | |
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| References | |
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| Reelin Glycoprotein in Autism and Schizophrenia | |
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| Reelin Gene and Protein | |
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| Reelin Signaling Cascade | |
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| The Reeler Mouse | |
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| Reelin in Autism | |
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| Reelin in Schizophrenia | |
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| Conclusions | |
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| References | |
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| Is There A Connection Between Autism, Prader-Willi Syndrome, Catatonia, and GABA? | |
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| Introduction | |
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| GABA in Autism | |
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| Plasma GABA as Marker for Autism | |
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| Insurgent Catatonia | |
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| GABA in Catatonia | |
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| Catatonia in Autism | |
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| Catatonia in Prader-Willi Syndrome | |
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| GABA in Prader-Willi Syndrome | |
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| Conclusion | |
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| References | |
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| Alcohol, GABA Receptors, and Neurodevelopmental Disorders | |
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| Introduction | |
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| Alcohol and Neurodevelopmental Disorders: Role of GABA and GABA Receptors | |
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| Conclusions | |
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| References | |
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| Effects of Secretin on Extracellular GABA and Other Amino Acid Concentrations in the Rat Hippocampus | |
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| Introduction | |
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| Aim | |
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| Materials and Methods | |
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| Results | |
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| Discussion | |
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| References | |
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| Predicted Role of Secretin and Oxytocin in the Treatment of Behavioral and Developmental Disorders: Implications for Autism | |
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| Introduction | |
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| Background | |
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| Findings | |
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| Future Directions | |
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| Conclusion | |
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| References | |
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| Immunological Findings in Autism | |
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| Introduction | |
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| Immune Dysfunction in Autism | |
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| Role of Viral Infections in Autistic Development | |
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| Role of Environmental Factors in Autistic Development | |
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| Inflammatory Mediators in Autism | |
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| Involvement of Toll-Like Receptors (TLRs) in Autism | |
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| Autoimmunity in Autism | |
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| Summary | |
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| References | |
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| Correlates of Psychomotor Symptoms in Autism | |
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| Introduction | |
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| Stereotypic Behaviors | |
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| Conclusion | |
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| References | |
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| GABRB3 Gene Deficient Mice: A Potential Model of Autism Spectrum Disorder | |
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| Introduction | |
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| Molecular Characteristics of GABRB3 Null Mice | |
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| Morphology | |
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| Neurochemistry | |
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| Electrophysiology | |
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| Epilepsy | |
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| Behavior | |
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| Concluding Remarks | |
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| References | |
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| The Reeler Mouse: Anatomy of a Mutant | |
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| Introduction | |
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| Neuroanatomy of Reeler and Reeler-Like Mutants | |
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| Reelin | |
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| The Reelin Signaling Pathway | |
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| The Biological Activities of Reelin | |
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| Reelin and Human Diseases | |
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| References | |
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| Shared Chromosomal Susceptibility Regions Between Autism and Other Mental Disorders | |
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| Introduction | |
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| Conclusion | |
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| References | |
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| Index | |
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| Contents of Recent Volumes | |