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Medical Biochemistry

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ISBN-10: 0120954400

ISBN-13: 9780120954407

Edition: 4th 2002 (Revised)

Authors: N. V. Bhagavan

List price: $130.00
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This text presents the fundamentals of biochemistry and related topics for all those pursuing medical or other health-related fields such as clinical chemistry, medical technology, or pharmacology.
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Book details

List price: $130.00
Edition: 4th
Copyright year: 2002
Publisher: Elsevier Science & Technology Books
Publication date: 9/20/2001
Binding: Hardcover
Pages: 1016
Size: 8.75" wide x 11.25" long x 2.25" tall
Weight: 5.896
Language: English

Contributors
Preface
Acknowledgments
Water, Acids, Bases, and Buffers
Properties of Water
Buffers
Measurement of pH
H[superscript +] Concentration and pH
Supplemental Readings and References
Amino Acids
L-[alpha]-Amino Acids: Structure
Classification
Electrolyte and Acid-Base Properties
Chemical Reactions of Amino Acids
Supplemental Readings and References
Protein Isolation and Determination of Amino Acid Sequence
Quantitative Determination of Proteins
Determination of Primary Structure
Separation of Proteins
Capillary Electrophoresis
Amino Acid Composition
Amino Acid Sequence Determination
Supplemental Readings and References
Three-Dimensional Structure of Proteins
Attractive and Repulsive Forces in Proteins
Primary Structure
Secondary Structure
Tertiary Structure
Quaternary Structure
Denaturation
Protein Folding and Associated Diseases
Supplemental Readings and References
Thermodynamics, Chemical Kinetics, and Energy Metabolism
Methods of Altering the Rate of Reactions
Thermodynamics
Standard Free Energy of Hydrolysis of ATP
Chemical Kinetics
Energy Metabolism
Obesity
Supplemental Readings and References
Enzymes I: General Properties, Kinetics, and Inhibition
Nomenclature
Catalysis
Kinetics of Enzymes Catalyzing Two-Substrate Reactions
Inhibition
Kinetics of Ligand-Receptor Interaction
Mechanisms of Enzyme Action
Supplemental Readings and References
Enzymes II: Regulation
Types of Regulation
Allosteric Enzyme Regulation
Supplemental Readings and References
Enzymes III: Clinical Applications
Diagnosis and Prognosis of Disease
Serum Markers in the Diagnosis of Tissue Damage
Enzymes as Analytical Reagents
Enzymes as Therapeutic Agents
Supplemental Readings and References
Simple Carbohydrates
Classification
Supplemental Readings and References
Heteropolysaccharides I: Glycoproteins and Glycolipids
Glycoproteins
Cell Membrane Constituents
Cell-Surface Glycoproteins
Serum Glycoproteins
Molecular Mimicry of Oligosaccharides and Host Susceptibility
Supplemental Readings and References
Heteropolysaccharides II: Proteoglycans and Peptidoglycans
Protein Fibers and Proteoglycans
Peptidoglycans
Lectins
Supplemental Readings and References
Gastrointestinal Digestion and Absorption
Anatomy and Physiology of the GI Tract
Gastrointestinal Hormones
Digestion and Absorption of Major Food Substances
Absorption of Water and Electrolytes
Thermic Effect of Food
Supplemental Readings and References
Carbohydrate Metabolism I: Glycolysis and TCA Cycle
Glycolysis
Pyruvate Metabolism
Tricarboxylic Acid (TCA) Cycle
Supplemental Readings and References
Electron Transport and Oxidative Phosphorylation
Mitochondrial Structure and Properties
Oxidative Phosphorylation
Mitochondrial Energy States
The Mitochondrial Genome
Nuclear Control of Respiratory Chain Expression
Mitochondrial Diseases
Other Reducing-Equivalent Transport and Oxygen-Consuming Systems
Supplemental Readings and References
Carbohydrate Metabolism II: Gluconeogenesis, Glycogen Synthesis and Breakdown, and Alternative Pathways
Gluconeogenesis
Glycogen Metabolism
Alternative Pathways of Glucose Metabolism and Hexose Interconversions
Supplemental Readings and References
Carbohydrate Metabolism III: Glycoproteins, Glycolipids, GPI Anchors, Proteoglycans, and Peptidoglycans
Biosynthesis of Glycoproteins
Biosynthesis of Peptidoglycans
Supplemental Readings and References
Protein and Amino Acid Metabolism
Essential and Nonessential Amino Acids
Metabolism of Ammonia
Metabolism of Some Individual Amino Acids
Supplemental Readings and References
Lipids I: Fatty Acids and Eicosanoids
Oxidation of Fatty Acids
Metabolism of Ketone Bodies
Metabolism of Ethanol
Synthesis of Long-Chain Saturated Fatty Acids
Metabolism of Unsaturated Fatty Acids
Nonessential Fatty Acids
Trans-Fatty Acids
Essential Fatty Acids
Metabolism of Eicosanoids
Supplemental Readings and References
Lipids II: Phospholipids, Glycosphingolipids, and Cholesterol
Phospholipids
Phospholipids and Glycosphingolipids in Clinical Medicine
Cholesterol
Bile Acids
Supplemental Readings and References
Lipids III: Plasma Lipoproteins
Structure and Composition
Metabolism
Lipoprotein-Associated Disorders
Supplemental Readings and References
Muscle and Nonmuscle Contractile Systems
Muscle Systems
Mechanism of Muscle Contraction: Overview
Energy Supply in Muscle
Inherited Diseases of Muscle
Nonmuscle Systems
Drugs Affecting Microtubules
Supplemental Readings and References
Metabolic Homeostasis
Metabolic Homeostasis
Metabolic Roles of Organs
Endocrine Pancreas and Pancreatic Hormones
Stored Fuels
Carbohydrate Homeostasis
Lipid Homeostasis
Protein Synthesis and Nitrogen Homeostasis
Abnormalities of Metabolic Homeostasis
Metabolic Homeostasis during Exercise
Supplemental Readings and References
Nucleic Acid Structure and Properties of DNA
Components of Nucleic Acids
Physical and Chemical Structure of DNA
Denaturation of DNA
Renaturation of DNA
Repetitive DNA Sequences
Degradation of DNA
Diagnostic and Clinical Applications of DNA
DNA Vaccines
The Human Genome Project
Genomics and Proteomics
Supplemental Readings and References
DNA Replication, Repair, and Mutagenesis
DNA Replication
Enzymology of DNA Replication
The Replication Fork
Chromosome Replication
DNA Repair
DNA Mutation
Supplemental Readings and References
RNA and Protein Synthesis
Structure of RNA
Messenger RNA
Enzymatic Synthesis of RNA
Prokaryotic Transcription
Transcription in Eukaryotes
Genetic Code
Attachment of Amino Acid to tRNA Molecule
Initiator tRNA Molecules and Selection of Initiation Codon
Ribosomes
Protein Synthesis
Collagen Biosynthesis and Its Disorders
Supplemental Readings and References
Regulation of Gene Expression
Regulation of mRNA
Gene Regulation in Prokaryotes
Gene Regulation in Eukaryotes
Mechanisms of Gene Regulation in Eukaryotes
Regulation of Cell Death: Apoptosis
Regulation of Cell Proliferation: Oncogenes
Retroviruses and AIDS
Supplemental Readings and References
Nucleotide Metabolism
One-Carbon Metabolism
Formation of 5-Phosphoribosyl-1-Pyrophosphate
Biosynthesis of Purine Nucleotides
Conversion of Nucleoside Monophosphates to Diphosphates and Triphosphates
Formation of Purine Deoxyribonucleotides
Regulation of Purine Biosynthesis
Inhibitors of Purine Biosynthesis
Catabolism of Purine Nucleotides
Biosynthesis of Pyrimidine Nucleotides
Coordination of Purine and Pyrimidine Nucleotide Biosynthesis
Catabolism of Pyrimidine Nucleotides
Abnormalities of Pyrimidine Metabolism
Supplemental Readings and References
Hemoglobin
Structure of Hemoglobins
Functional Aspects of Hemoglobin
Inherited Disorders of Hemoglobin Structure and Synthesis
Derivatives of Hemoglobin
Supplemental Readings and References
Metabolism of Iron and Heme
Iron Metabolism
Heme Biosynthesis
Heme Catabolism
Supplemental Readings and References
Endocrine Metabolism I: Introduction
Hormonal Amines
Peptide, Protein, and Glycoprotein Hormones
Steroid Hormones
Mechanism of Hormone Action
Types of Hormone Receptors
Organization of the Endocrine System
Supplemental Readings and References
Endocrine Metabolism II: Hypothalamus and Pituitary
Hypothalamus
Pituitary Gland (Hypophysis)
Supplemental Readings and References
Endocrine Metabolism III: Adrenal Glands
Adrenal Cortex
Adrenal Medulla
Supplemental Readings and References
Endocrine Metabolism IV: Thyroid Gland
Structure-Activity of Thyroid Hormones
Thyroid Hormone Synthesis
Transport and Metabolism of Thyroid Hormones
Biological Actions of Thyroid Hormones
Supplemental Readings and References
Endocrine Metabolism V: Reproductive System
Testes
Ovaries
Supplemental Readings and References
Molecular Immunology
Innate Immunity
Acquired or Adaptive Immunity
Antibody-Dependent Cell-Mediated Cytotoxicity
Distinguishing Self from Nonself
Molecules and Chemical Processes of the Immune System
Immunoglobulin Structure and Function
B-Cell Clonal Selection and Proliferation
Antibody Diversity and Immunoglobulin Genes
Major Histocompatibility Complex (MHC) Genes
Complement
Cytokines
Vaccines
Supplemental Readings and References
Biochemistry of Hemostasis
Primary Hemostasis
Secondary Hemostasis
Functional Properties and Structures of the Hemostatic System Factors (Proteins)
Clotting
The Procoagulant Subsystem of Coagulation
The Extrinsic Pathway
The Intrinsic Pathway
Anticoagulant Subsystem--Activation of Protein C and Inactivation of Factors Va and VIIIa
Fibrinolytic Subsystem
Vitamin K, Oral Anticoagulants, and Their Mechanisms of Action
Coagulation Factor Measurements
Case Studies
Supplemental Readings and References
Mineral Metabolism
Calcium and Phosphorus
Magnesium
Nonessential Trace Elements
Metallothioneins
Essential Trace Elements
Supplemental Readings and References
Vitamin Metabolism
Fat-Soluble Vitamins
Water-Soluble Vitamins
Vitamin-Responsive Inherited Metabolic Disorders
Vitamin-like Substances
Supplemental Readings and References
Water, Electrolytes, and Acid-Base Balance
Water Metabolism
Homeostatic Controls
Water and Osmolality Controls
Electrolyte Balance
Acid-Base Balance
Supplemental Readings and References
Appendixes
Index