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| Editor's preface | |
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| Contributors to Volume 40 | |
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| Carbenes generated within cyclodextrins and zeolites | |
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| Introduction | |
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| Objectives | |
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| Supramolecular carbene chemistry | |
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| Conclusions | |
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| Acknowledgments | |
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| References | |
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| Mechanistic studies on enzyme-catalyzed phosphoryl transfer | |
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| Introduction | |
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| Uncatalyzed reactions of phosphomonoesters | |
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| Uncatalyzed reactions of phosphodiesters | |
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| Uncatalyzed reactions of phosphotriesters | |
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| Implications for enzymatic catalysis | |
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| Enzymes that catalyze transfer of the phosphoryl (PO[subscript 3]) group | |
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| Phosphodiesterases | |
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| Phosphotriesterases | |
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| References | |
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| Finite molecular assemblies in the organic solid state: toward engineering properties of solids | |
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| Introduction | |
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| Finite molecular assemblies | |
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| Supramolecular synthons, finite assemblies, and functional solids | |
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| Finite assemblies in the solid state | |
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| Our approach: template-controlled solid-state reactivity | |
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| Summary and outlook | |
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| Acknowledgment | |
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| References | |
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| The physical organic chemistry of very high-spin polyradicals | |
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| Introduction | |
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| Exchange coupling and magnetism | |
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| Preparation and characterization of polyarylmethyl polyradicals | |
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| High-spin versus low-spin polyradicals | |
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| Star-branched and dendritic polyarylmethyl polyradicals | |
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| Design of very high-spin polyradicals | |
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| Organic spin clusters | |
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| Very high-spin polyarylmethyl polymers | |
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| Conclusion and outlook | |
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| Acknowledgements | |
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| References | |
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| Computer modeling of enzyme catalysis and its relationship to concepts in physical organic chemistry | |
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| Introduction | |
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| Formulating chemical reactivity in solutions and in enzymes in a computationally convenient way; the empirical valence bond and other QM/MM methods | |
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| The EVB as a basis for LFER in solutions and enzymes | |
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| Proton transport in carbonic anhydrase as an example of the difference between microscopic and phenomenological LFERs | |
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| Protein reorganization energy and the preorganization concept | |
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| Applying our concepts to different catalytic proposals | |
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| Concluding remarks | |
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| Acknowledgments | |
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| References | |
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| Mechanisms of hydrolysis and rearrangements of epoxides | |
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| Introduction | |
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| Limiting mechanisms of epoxide reactions | |
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| Mechanisms of hydrolysis of epoxides derived from simple alkenes and cycloalkenes | |
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| Acid-catalyzed hydrolyses of alkyl- and vinyl-substituted epoxides | |
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| Mechanisms of hydrolysis of styrene oxides | |
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| Mechanisms of acid-catalyzed hydrolysis of 1-phenylcyclohexene oxides, indene oxides and 1,2,3,4-tetrahydronaphthalene-1,2-epoxides | |
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| General acid catalysis in epoxide reactions | |
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| pH-independent reactions of epoxides | |
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| Epoxide isomerization accompanying pH-independent reactions | |
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| Benzylic epoxides that exhibit complicated pH-rate profiles | |
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| Partitioning of hydroxycarbocations | |
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| Overall summary | |
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| Acknowledgments | |
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| References | |
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| Author Index | |
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| Cumulative Index of Authors | |
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| Cumulative Index of Titles | |
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| Subject Index | |