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Comprehensive Toxicology, Volume 9 Hepatic and Gastrointestinal Toxicology

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ISBN-10: 0080429742

ISBN-13: 9780080429748

Edition: 1997

Authors: D. L. Earnest, R. S. McCuskey

List price: $325.00
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Description:

This volume, which is separated into two parts, presents important new information concerning mechanisms of effect and consequences of exposure of the liver and gastrointestinal tract to a wide variety of toxicants. Both sections on the liver and GI tract provide the reader with concise introductory descriptions of relevant cellular and organ anatomy, physiology, and mechanisms of toxic injury. Specific consideration is given to methods of toxin exposure and to processes that provide defence against injury. The discussions provide a broad focus but also contain details about molecular, cellular, and biochemical mechanisms. The section on the liver (34 chapters) provides a comprehensive…    
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Book details

List price: $325.00
Copyright year: 1997
Publisher: Elsevier Science & Technology
Publication date: 8/4/1999
Binding: Hardcover
Pages: 750
Size: 7.44" wide x 9.69" long x 1.50" tall
Weight: 4.180
Language: English

Hepatic Toxicology. Introduction to the liver and its responses to toxicants
Structure and function of hepatic parenchymal cells
Hepatic nonparenchymal cells: endothelial cells
Cells of the liver: biliary epithelium
Xenobiotic metabolism by the liver
Evaluation of hepatotoxicity: physiological and biochemical measures of hepatic function
Pathological response to toxic injury
Xenobiotic-induced inflammation and injury in the liver
Carcinogenic responses to toxic liver injury in rodents
Antioxidant defense mechanisms
Proteases and transcription factors: cutting edge determinants of the proliferative or apoptotic response in hepatic tissue
Hepatic defenses against toxicity: regeneration
In vitro methods
Carbon tetrachloride
Volatile halogenated hydrocarbons
Hexachlorobenzene: effects on porphyrin metabolism
Hepatotoxicity of the fluorinated anesthetic agent
Role of Kupffer cells
Cocaine hepatotoxicity
Acetaminophen
Effects of chlorpromazine on the liver
Nitrofurantoin
Isoniazid
Pesticides
Hepatotoxicity of copper
Aflatoxin toxicology
Pyrrolizidine alkaloids
Bacterial endotoxin
agr;-Naphthylisothiocyanate
Allyl alcohol
Bromobenzene hepatotoxicity: a paradigm of reactive electrophilic metabolites binding covalently to tissue macromolecules. Is there light at the end of the tunnel?
D-galactosamine
Thioacetamide
The hepatotoxicity of Vitamin A
Gastrointestinal Toxicology. Gastrointestinal system: introduction
Anatomy esophagus stomach small intestine colon)
Gastrointestinal system: overview of physiology
The gastrointestinal tract immune system
The metabolic barrier of the gastrointestinal tract
Pathophysiological mechanisms of gastrointestinal toxicity
Interaction of toxicants with gastrointestinal tract microbial flora
Toxicants and gastrointestinal tract cellular proliferation and cancer
Sources of gastrointestinal tract toxins
Absorption
Clinical toxicity of common drugs and chemicals: esophagus
Clinical toxicity of common drugs and chemicals in humans: stomach
Small bowel toxicology
Clinical toxicity of common drugs and chemicals: colon
In vitro and in vivo models of gastrointestinal toxicology
Clinical toxicology in animals