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| Preface | |
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| The Integrated Response to a Meal | |
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| Functional Anatomy of the GI Tract and Organs Draining into it | |
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| Objectives | |
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| Overview of the Gastrointestinal System and its Functions | |
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| Engineering Considerations | |
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| Organs and Systems Involved in the Response to a Meal | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Neurohumoral Regulation of Gastrointestinal Function | |
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| Objectives | |
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| Requirement for Integrated Regulation | |
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| Communication in the GI Tract | |
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| Principles of Endocrine Regulation | |
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| Principles of Neurocrine Regulation | |
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| Paracrine and Immune Regulation | |
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| Integration of Regulatory Systems | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Intestinal Secretory Functions | |
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| Gastric Secretion | |
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| Objectives | |
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| Basic Principles of Gastric Secretion | |
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| Anatomical Considerations | |
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| Regulation of Gastric Secretion | |
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| Cellular Basis of Secretion | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Pancreatic and Salivary Secretion | |
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| Objectives | |
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| Basic Principles of Pancreatic Secretion | |
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| Anatomic Considerations in Pancreas | |
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| Regulation of Pancreatic Secretion | |
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| Cellular Basis of Pancreatic Secretion | |
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| Pancreatic Pathophysiology and Clinical Correlations | |
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| Basic Principles of Salivary Secretion | |
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| Salivary Gland Anatomy | |
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| Regulation of Salivary Secretion | |
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| Cellular Basis of Salivary Secretion | |
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| Salivary Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Water and Electrolyte Absorption and Secretion | |
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| Objectives | |
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| Basic Principles of Intestinal Fluid Transport | |
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| Anatomical Considerations | |
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| Regulation of Water and Electrolyte Transport | |
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| Cellular Basis of Transport | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Intestinal Mucosal Immunology and Ecology | |
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| Objectives | |
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| Basic Principles of Mucosal Immunology | |
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| Functional Anatomy of the Mucosal Immune System | |
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| Secretory IgA System | |
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| Immune Response to Enteric Antigens | |
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| Intestinal Microecology | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Motility | |
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| Esophageal Motility | |
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| Objectives | |
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| Basic Principles of Esophageal Motility | |
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| Functional Anatomy of the Esophageal Musculature | |
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| Features of Esophageal Motility | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Gastric Motility | |
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| Objectives | |
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| Basic Principles of Gastric Motility | |
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| Functional Anatomy of the Gastric Musculature | |
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| Features of Gastric Motility | |
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| Pathophysiology and Clinical Correlates | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Intestinal Motility | |
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| Objectives | |
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| Basic Principles of Intestinal Motility | |
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| Functional Anatomy | |
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| Features of Intestinal Motility | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Transport and Metabolic Functions of the Liver | |
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| Functional Anatomy of the Liver and Biliary System | |
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| Objectives | |
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| Overview of the Liver and Biliary System and their Functions | |
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| Engineering Considerations | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Bile Formation and Secretion | |
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| Objectives | |
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| Basic Principles of Biliary Excretion and Secretion | |
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| Bile Acid Metabolism | |
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| Bile Composition | |
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| Enterohepatic Circulation of Bile Acids | |
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| Pathophysiology and Clinical Correlates | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Gallbladder Function | |
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| Objectives | |
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| Basic Principles of Gallbladder Function | |
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| Functional Anatomy of the Gallbladder | |
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| Gallbladder Storage of Bile | |
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| Motor Functions of the Gallbladder and Biliary System | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Bilirubin Formation and Excretion by the Liver | |
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| Objectives | |
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| Basic Principles of Bilirubin Metabolism | |
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| Pathways of Bilirubin Synthesis and Metabolism | |
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| Bilirubin Homeostasis | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Ammonia and Urea | |
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| Objectives | |
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| Basic Principles of Ammonia Metabolism | |
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| Ammonia Formation and Disposition | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Digestion and Absorption | |
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| Carbohydrate, Protein and Water Soluble Vitamin Assimilation | |
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| Objectives | |
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| Basic Principles of Carbohydrate and Protein Assimilation | |
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| Carbohydrate Assimilation | |
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| Protein Assimilation | |
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| Water-Soluble Vitamin Assimilation | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Lipid Assimilation | |
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| Objectives | |
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| General Principles of Lipid Assimilation | |
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| Intraluminal Digestion | |
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| Epithelial Events in Lipid Assimilation | |
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| Absorption of Fat Soluble Vitamins | |
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| Pathophysiology and Clinical Correlations | |
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| Key Concepts | |
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| Study Questions | |
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| Suggested Readings | |
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| Answers to Study Questions | |
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| Index | |