Clinical Chemistry Concepts and Applications

Name: Clinical Chemistry Concepts and Applications
Price: 5.84 USD
Availability: InStock
ISBN: 9780071360470

ISBN-10: 0071360476

ISBN-13: 9780071360470

Edition: 2003

Authors: Shauna C. Anderson, Susan Cockayne

List price: $82.95

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The emphasis in this student textbook is on the theory, concepts and applications of clinical laboratory science. It is packed with pedagogical features including chapter outlines, review material and concept applications.

Book details

List price: $82.95
Copyright year: 2003
Publisher: McGraw-Hill Professional Publishing
Publication date: 12/2/2002
Binding: Paperback
Pages: 723
Size: 8.50" wide x 11.00" long x 1.25" tall
Weight: 3.982
Language: English

Reference Ranges
Contributors	p. xi
Foreword	p. xiii
Preface	p. xv
Acknowledgments	p. xvii
Laboratory Resources	p. 1
Pipets	p. 1
Dispensers	p. 5
Glassware and Plasticware	p. 6
Cleaning Labware	p. 7
Chemical Reagents and Handling	p. 8
Reference Materials and Controls	p. 9
Water Purification	p. 10
Basic Chemistry Equipment	p. 11
Centrifuges	p. 13
Summary	p. 15
Laboratory Reagents and Calculations	p. 17
Reagents	p. 17
Standards	p. 17
Laboratory Calculations	p. 17
Summary	p. 26
Laboratory Safety	p. 27
Regulations	p. 27
Safety Practices	p. 27
Fire Safety	p. 29
Chemical Safety	p. 30
Compressed Gases	p. 35
Electrical Safety	p. 35
Biological Safety	p. 36
Radiation Safety	p. 37
Laboratory Safety Program	p. 38
Summary	p. 38
Resources for Safety Information	p. 39
Quality Assurance	p. 41
The Quality Management Framework	p. 41
Quality Control Monitoring	p. 42
Summary	p. 62
Method Evaluation and Preanalytical Variables	p. 65
Method Evaluation	p. 65
Reference Intervals	p. 73
Preanalytical Variables	p. 74
Components of an Effective CQI/QA Program	p. 77
Summary	p. 78
Spectrophotometry	p. 81
Spectrophotometric Principles	p. 81
Spectrophotometric Instruments	p. 85
Summary	p. 93
Principles of Molecular and Immunoassays	p. 95
Introduction	p. 95
Specimen Collection and Handling	p. 98
Immunoassays	p. 98
Enzyme Labels	p. 104
Fluorescent Labels	p. 108
Molecular Assays	p. 110
Summary	p. 128
Laboratory Automation	p. 131
Robotics	p. 131
Stages of Automated Analysis	p. 132
Examples of Specific Systems	p. 136
Instrument Selection	p. 138
Summary	p. 138
Computers in the Clinical Laboratory	p. 141
Computer Hardware and Software	p. 141
Networking and Communication	p. 147
Laboratory Information Systems	p. 151
Medical Informatics	p. 151
Summary	p. 152
Carbohydrates	p. 153
Definitions and Basic Principles	p. 153
Classification	p. 153
Metabolism	p. 156
Hormonal Regulation	p. 157
Clinical Applications	p. 159
Cerebrospinal Fluid Glucose	p. 169
Analytical Procedures	p. 169
Summary	p. 175
Lipids	p. 179
Classification of Lipids	p. 179
Metabolism of Lipids	p. 182
Lipoproteins	p. 184
Analytical Procedures for Lipids	p. 188
Pathophysiology	p. 192
Summary	p. 198
Proteins	p. 203
Classification	p. 203
Metabolism: Synthesis and Degradation	p. 206
General Analytical Processes	p. 206
Clinical Applications	p. 211
Protein in Other Body Fluids	p. 220
Summary	p. 221
Inherited Metabolic Disorders	p. 223
Overview of Genetic Disorders	p. 223
Clinical Applications in Detecting Metabolic Related Disorders	p. 228
Analytical Procedures: Past, Present, and Anticipated	p. 236
Summary	p. 237
Immunologic Disorders	p. 239
Autoimmunity	p. 239
Clinical Applications	p. 244
Summary	p. 255
Clinical Enzymology	p. 261
Measuring Enzymes	p. 261
Clinically Significant Enzymes	p. 269
Clinical Applications	p. 278
Summary	p. 283
Liver Function	p. 285
Liver Anatomy	p. 285
Liver Function	p. 286
Analytical Procedures	p. 290
Clinical Applications	p. 297
Summary	p. 319
Tumor Markers	p. 323
Characteristics of an Ideal Tumor Marker	p. 324
Uses of Tumor Markers	p. 324
Biologic Sources	p. 324
Classification	p. 325
Clinical Applications	p. 337
New Directions	p. 339
Summary	p. 340
Porphyrins	p. 343
Biosynthesis of Porphyrins and Heme	p. 345
Clinical Applications	p. 346
Laboratory Diagnosis of Porphyrin Disorders	p. 349
Analytical Procedures	p. 350
Summary	p. 353
Renal Anatomy and Physiology	p. 355
Renal Anatomy	p. 355
Renal Physiology	p. 362
Summary	p. 371
Renal Function: Nonprotein Nitrogen Compounds, Function Tests, and Renal Disease	p. 373
Nonprotein Nitrogen Compounds	p. 373
Assessment of Renal Function	p. 380
Clinical Applications	p. 391
Summary	p. 397
Electrolytes	p. 401
Total Body Water	p. 401
Osmolality	p. 401
Electrolytes	p. 402
Analytical Procedures	p. 416
Summary	p. 419
Acid-Base and Blood Gas Physiology	p. 421
Clinically Important Gases	p. 421
Maintenance of Acid-Base Balance	p. 426
Disturbances of Acid-Base Balance	p. 431
Laboratory Evaluation	p. 435
The Extended Laboratory	p. 438
Therapeutic Drug Monitoring	p. 441
Drug Action	p. 441
Drug Disposition	p. 442
Pharmacokinetics	p. 445
Variable Affecting Drug Disposition	p. 447
Sample Collection and Data Reporting	p. 447
Therapeutic Drug Monitoring	p. 448
Summary	p. 452
Toxicology	p. 455
Classes of Toxic Substances	p. 455
Drugs of Abuse and Overdose	p. 466
Analytical Procedures	p. 471
Summary	p. 474
Introduction to Hormones and Endocrinology	p. 477
Classification of Hormones	p. 477
Regulation of Hormone Secretion	p. 480
Mechanisms of Action	p. 480
Disorders of the Endocrine System	p. 481
Summary	p. 481
Hypothalamus and Pituitary Endocrinology	p. 483
Hypothalamus	p. 483
Pineal Gland	p. 483
Pituitary (Hypophysis) Gland	p. 483
Summary	p. 489
Thyroid Endocrinology	p. 491
Thyroid Anatomy	p. 491
Thyroid Physiology	p. 491
Thyroid Function Testing	p. 496
Clinical Applications	p. 501
Summary	p. 508
The Parathyroid Glands and Calcium-Phosphate Metabolism	p. 511
Anatomy	p. 511
Parathyroid Hormone	p. 511
Regulation of Calcium and Phosphorus	p. 511
Specific Analytes	p. 513
Clinical Applications	p. 515
Summary	p. 519
Adrenocortical Endocrinology	p. 521
Anatomy	p. 521
Adrenal Hormones	p. 521
Adrenal Function Tests	p. 525
Clinical Applications	p. 526
Summary	p. 528
Adrenal Medullary Endocrinology	p. 531
Anatomy	p. 531
Adrenal Medullary Hormones	p. 531
Clinical Applications	p. 534
Summary	p. 535
Reproductive Endocrinology	p. 537
Male Reproductive System	p. 537
Female Reproductive System	p. 540
Structure and Function of Gonadal Steroids	p. 544
Mechanism of Hormone Action	p. 547
Analytes	p. 549
Clinical Applications	p. 551
Defects of Androgen Metabolism	p. 553
Gonadal Function Tests	p. 554
Summary	p. 554
Gastrointestinal and Pancreatic Function	p. 557
Gastrointestinal Organs	p. 557
Accessory Organs	p. 560
Digestion	p. 561
Regulation of Digestion by Gastrointestinal Hormones	p. 562
Clinical Applications	p. 563
Laboratory Diagnosis of Dysfunction	p. 570
Summary	p. 577
Nutritional Status Assessment	p. 579
Nutritional Status	p. 579
Proteins	p. 580
Vitamins and Mineral Status	p. 586
Trace and Ultratrace Elements	p. 600
Summary	p. 608
Point-of-Care Testing	p. 613
The POCT Laboratory	p. 613
Evaluation	p. 614
POCT Testing and Instrumentation	p. 616
Billing	p. 617
Summary	p. 617
Laboratory Assessment of Psychiatric Disorders	p. 619
Supporting the Psychiatric Diagnosis and Plan of Treatment	p. 619
Medical Conditions Underlying Diagnosis and Treatment	p. 620
Screening for the Biochemical Basis of Psychiatric Disorders	p. 621
Monitoring Therapeutic Treatment	p. 622
Summary	p. 623
Biochemical Assessment During Pregnancy	p. 625
Biochemical Changes	p. 625
Analytes	p. 629
Clinical Applications	p. 633
Summary	p. 635
Neonatal and Pediatric Laboratory Assessment	p. 637
Developmental Differences	p. 637
Perinatal Physiology	p. 637
Laboratory Assessment in the Pediatric Population	p. 640
Summary	p. 646
Geriatric Laboratory Assessment	p. 649
The "New" Elderly	p. 649
Theories of Aging	p. 651
Biochemical Changes	p. 654
Nutrition in Aging	p. 670
Vitamin Status	p. 671
Reference Ranges	p. 676
Clinical Applications	p. 677
Summary	p. 681
Index	p. 687
Selected Atomic Weights
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