| Contributors | p. xi |
| Consultants to the Editors | p. xvii |
| Preface | p. xxi |
| Preface to the First Edition | p. xxiii |
| General Principles | p. 1 |
| Pharmacokinetics and Pharmacodynamics: The Dynamics of Drug Absorption, Distribution, Action, and Elimination | p. 1 |
| Membrane Transporters and Drug Response | p. 41 |
| Drug Metabolism | p. 71 |
| Pharmacogenetics | p. 93 |
| The Science of Drug Therapy | p. 117 |
| Drugs Acting at Synaptic and Neuroeffector Junctional Sites | p. 137 |
| Neurotransmission: The Autonomic and Somatic Motor Nervous Systems | p. 137 |
| Muscarinic Receptor Agonists and Antagonists | p. 183 |
| Anticholinesterase Agents | p. 201 |
| Agents Acting at the Neuromuscular Junction and Autonomic Ganglia | p. 217 |
| Adrenergic Agonists and Antagonists | p. 237 |
| 5-Hydroxytryptamine (Serotonin): Receptor Agonists and Antagonists | p. 297 |
| Drugs Acting on the Central Nervous System | p. 317 |
| Neurotransmission and the Central Nervous System | p. 317 |
| General Anesthetics | p. 341 |
| Local Anesthetics | p. 369 |
| Therapeutic Gases: Oxygen, Carbon Dioxide, Nitric Oxide, and Helium | p. 387 |
| Hypnotics and Sedatives | p. 401 |
| Drug Therapy of Depression and Anxiety Disorders | p. 429 |
| Pharmacotherapy of Psychosis and Mania | p. 461 |
| Pharmacotherapy of the Epilepsies | p. 501 |
| Treatment of Central Nervous System Degenerative Disorders | p. 527 |
| Opioid Analgesics | p. 547 |
| Ethanol | p. 591 |
| Drug Addiction and Drug Abuse | p. 607 |
| Autacoids: Drug Therapy of Inflammation | p. 629 |
| Histamine, Bradykinin, and Their Antagonists | p. 629 |
| Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor | p. 653 |
| Analgesic-Antipyretic Agents; Pharmacotherapy of Gout | p. 671 |
| Pharmacotherapy of Asthma | p. 717 |
| Drugs Affecting Renal and Cardiovascular Function | p. 737 |
| Diuretics | p. 737 |
| Vasopressin and Other Agents Affecting the Renal Conservation of Water | p. 771 |
| Renin and Angiotensin | p. 789 |
| Treatment of Myocardial Ischemia | p. 823 |
| Therapy of Hypertension | p. 845 |
| Pharmacotherapy of Congestive Heart Failure | p. 869 |
| Antiarrhythmic Drugs | p. 899 |
| Drug Therapy for Hypercholesterolemia and Dyslipidemia | p. 933 |
| Drugs Affecting Gastrointestinal Function | p. 967 |
| Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease | p. 967 |
| Treatment of Disorders of Bowel Motility and Water Flux; Antiemetics; Agents Used in Biliary and Pancreatic Disease | p. 983 |
| Pharmacotherapy of Inflammatory Bowel Disease | p. 1009 |
| Chemotherapy of Parasitic Infections | p. 1021 |
| Chemotherapy of Protozoal Infections: Malaria | p. 1021 |
| Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections | p. 1049 |
| Chemotherapy of Helminth Infections | p. 1073 |
| Chemotherapy of Microbial Diseases | p. 1095 |
| General Considerations of Antimicrobial Therapy | p. 1095 |
| Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections | p. 1111 |
| Penicillins, Cephalosporins, and Other [beta]-Lactam Antibiotics | p. 1127 |
| Aminoglycosides | p. 1155 |
| Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents | p. 1173 |
| Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy | p. 1203 |
| Antifungal Agents | p. 1225 |
| Antiviral Agents (Nonretroviral) | p. 1243 |
| Antiretroviral Agents and Treatment of HIV Infection | p. 1273 |
| Chemotherapy of Neoplastic Diseases | p. 1315 |
| Antineoplastic Agents | p. 1315 |
| Immunomodulators | p. 1405 |
| Immunosuppressants, Tolerogens, and Immunostimulants | p. 1405 |
| Drugs Acting on the Blood and the Blood-Forming Organs | p. 1433 |
| Hematopoietic Agents: Growth Factors, Minerals, and Vitamins | p. 1433 |
| Blood Coagulation and Anticoagulant, Thrombolytic, and Antiplatelet Drugs | p. 1467 |
| Hormones and Hormone Antagonists | p. 1489 |
| Pituitary Hormones and Their Hypothalamic Releasing Factors | p. 1489 |
| Thyroid and Antithyroid Drugs | p. 1511 |
| Estrogens and Progestins | p. 1541 |
| Androgens | p. 1573 |
| Adrenocorticotropic Hormone; Adrenocortical Steroids and Their Synthetic Analogs; Inhibitors of the Synthesis and Actions of Adrenocortical Hormones | p. 1587 |
| Insulin, Oral Hypoglycemic Agents, and the Pharmacology of the Endocrine Pancreas | p. 1613 |
| Agents Affecting Mineral Ion Homeostasis and Bone Turnover | p. 1647 |
| Dermatology | p. 1679 |
| Dermatological Pharmacology | p. 1679 |
| Ophthalmology | p. 1707 |
| Ocular Pharmacology | p. 1707 |
| Toxicology | p. 1739 |
| Principles of Toxicology and Treatment of Poisoning | p. 1739 |
| Heavy Metals and Heavy-Metal Antagonists | p. 1753 |
| Appendices | |
| Principles of Prescription Order Writing and Patient Compliance | p. 1777 |
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