Human Diabetes: Genetic, Environmental and Autoimmune Etiology
List Price: $99.00
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Binding: Trade Paper
Size: 4.33" wide x 61.42" long x 92.13" tall
Insulin dependent diabetes mellitus, IDDM, develops primarily in genetically predisposed individuals under the influence of autoimmune or environmental factors. This volume brings together the latest knowledge of all factors which are involved in the destruction of the pancreatic -cell and thus lead to IDDM. Section I on genetics provides an up to date review of the characterization of the role of MHC-class II alleles in this disease and the structural dissection of susceptibility genes in this region with particular emphasis on the role of Asp 57 in HLA-DQ. Section II on the etiology of -cell destruction deals with mechanisms of generation of tolerance to -cell antigens and the possible More...
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