Handbook of Essential Psychopharmacology

ISBN-10: 1585621684
ISBN-13: 9781585621682
Edition: 2nd 2005 (Revised)
List price: $99.00
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Description: Handbook of Essential Psychopharmacology," Second Edition, provides an indispensable guide to vital information in the rapidly expanding field of psychopharmacology. The updated edition of this popular handbook will continue to be a reference that  More...

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Book details

List price: $99.00
Edition: 2nd
Copyright year: 2005
Publisher: American Psychiatric Publishing
Publication date: 4/11/2005
Binding: Paperback
Pages: 556
Size: 5.50" wide x 8.00" long x 1.00" tall
Weight: 1.386
Language: English

Handbook of Essential Psychopharmacology," Second Edition, provides an indispensable guide to vital information in the rapidly expanding field of psychopharmacology. The updated edition of this popular handbook will continue to be a reference that is simply the essential starting point in psychopharmacology for residents and experienced clinicians alike. Busy residents and clinicians will find a quick, current, and accessible guide to basic facts about psychotropic drugs, including dosages, indications, and drug interactions. As in the first edition, its structure is clear and easy to read

Preface to the Second Edition
Introduction to Pharmacodynamics and Pharmacokinetics
Pharmacodynamics
Ligands and Receptors
Neurotransmitters and Signal Transduction
Drug mechanism of action (pharmacodynamics)
Pharmacokinetics
Absorption
Distribution
Elimination
Drug Metabolism
General Issues
Cytochrome Families
Selected substrates, inhibitors, and inducers of major cytochrome P450 enzymes
Glucuronidation
Drug-Drug Interactions
Conclusion
References
Antidepressants
Overview
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Tables
Drug Class
Classification of antidepressants by putative neurotransmitter effects
Non-MAOI antidepressants: formulations, strengths, and usual maintenance dosage
Monoamine oxidase inhibitors (MAOIs): tablet strengths and usual adult dosage
Relative monthly cost of selected antidepressants (low/middle therapeutic dosage range)
Indications
"Off-label" and non-mood disorder indications for antidepressants
Mechanisms of Action
Neurotransmitter effects of selected antidepressants
Effects of reuptake blockade and receptor antagonism
Effects of serotonin (5-HT) receptor stimulation
Pharmacokinetics
Pharmacokinetics of selected antidepressants
Pharmacodynamic and pharmacokinetic profiles of newer antidepressants
Putative optimal plasma levels for tricyclic antidepressants
Main Side Effects
Side-effect profiles of commonly used antidepressants
Side effects of tricyclic vs. selected nontricyclic antidepressants (% of patients reporting, placebo adjusted)
Cardiac and autonomic side effects of selected antidepressants
Gastrointestinal and sexual side effects of selected antidepressants
Neurobehavioral side effects of selected antidepressants
Some comparative side effects of selective serotonin reuptake inhibitors (placebo-adjusted %)
Basic management of antidepressant side effects
Selected co-prescribed agents for antidepressant-induced sexual dysfunction
Drug-Drug Interactions
Drug-drug interactions with tricyclic antidepressants (TCAs)
Some drugs used in clinical practice that may interact with selective serotonin reuptake inhibitors (SSRIs) and related antidepressants
Drug-drug interactions with monoamine oxidase inhibitors (MAOIs)
Food restrictions for patients taking conventional monoamine oxidase inhibitors (MAOIs)
The serotonin syndrome: differential diagnosis
Serotonin syndrome
Potentiating Maneuvers
Agents used to potentiate or augment antidepressants
Psychostimulants and related agents: main features
Use in Special Populations
Selection of nontricyclic antidepressants for patients with special needs or comorbid conditions
Antidepressant dosing in children and adolescents
Questions and Answers
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Vignettes/Puzzlers
References
Antipsychotics
Overview
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Tables
Drug Class
Dosages and putative therapeutic levels of currently available antipsychotics
First-generation ("typical" or "neuroleptic") antipsychotic dosage equivalents of 10 mg of haloperidol
Second-generation ("atypical") antipsychotic dosage equivalents of 10 mg of haloperidol
Comparative costs of some atypical antipsychotics
Indications
Indications for use of antipsychotics
Mechanisms of Action
Relative receptor affinities of haloperidol versus available atypical agents
Pharmacokinetics
Pharmacokinetic profiles of first-generation (neuroleptic) antipsychotics
Pharmacokinetic profiles of second-generation (atypical) antipsychotics
Main Side Effects
Comparative side effects among available first-generation (typical) antipsychotics
Comparative side effects among selected second-generation (atypical) antipsychotics
Motor and mental symptoms of neurolepticinduced extrapyramidal side effects
Selected agents for treatment of extrapyramidal side effects (EPS) of first-generation (neuroleptic) antipsychotics
Neuroleptic malignant syndrome (NMS): differential diagnosis
Management of antipsychotic (AP) side effects
Clozapine and white blood cell count (WBC): managing abnormalities
Drug-Drug Interactions
Antipsychotic (AP) drug interactions
Second-generation (atypical) antipsychotics (APs): potential drug-drug interactions
Potentiating Maneuvers
Potentiation of antipsychotics (APs)
Use in Special Populations
Antipsychotics (APs) in special populations
Questions and Answers
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Vignettes/Puzzlers
References
Anxiolytics and Sedative-Hypnotics
Overview
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Tables
Drug Class
Commonly used benzodiazepine anxiolytics
Commonly prescribed benzodiazepine and nonbenzodiazepine hypnotics
Nonbenzodiazepine anxiolytics and hypnotics
Dosage and cost of selected benzodiazepines
Indications
Indications for benzodiazepines (BZDs)
Selective serotonin reuptake inhibitors (SSRIs) or related antidepressants with FDA-approved labeling for use in treating DSM-IV-TR anxiety disorders
Off-label uses for beta-blockers and clonidine for anxiety/agitation in selected disorders
Mechanisms of Action
Effect of various agents on GABA[subscript A] receptors
Pharmacodynamic aspects of hypnotic agents
Pharmacokinetics
Pharmacokinetics of orally administered benzodiazepine anxiolytics
Pharmacokinetics of benzodiazepine hypnotics
Pharmacokinetics of nonbenzodiazepine hypnotics
Simplified metabolic pathways of benzodiazepines
Main Side Effects
Frequency (%) of benzodiazepine (BZD) and buspirone side effects (average for various BZDs)
Side effects and management of benzodiazepines (BZDs)
Drug-Drug Interactions
Benzodiazepine (BZD) drug interactions
Nonbenzodiazepine (non-BZD) hypnotic drug interactions
Potentiating Maneuvers
Agents used in combination with benzodiazepines (BZDs) for augmentation of effect
Use in Special Populations
Potential concerns of benzodiazepine (BZD) use during pregnancy
Risks of benzodiazepine (BZD) use in elderly and/or dementia patients
Questions and Answers
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Vignettes/Puzzlers
References
Mood Stabilizers
Overview
Drug Class
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Tables
Drug Class
Selected mood stabilizers: preparations, usual daily doses, and putative therapeutic blood levels
Indications
Indications for lithium
Preferred treatments of acute manic or mixed episodes in bipolar disorder
Preferred treatments of acute depressive episodes in bipolar disorder
Preferred treatments of rapid cycling in bipolar disorder
Preferred maintenance treatments in bipolar disorder
Mechanisms of Action
Mood stabilizer and anticonvulsant mechanisms of action
Pharmacokinetics
Pharmacokinetics of selected mood stabilizers
Main Side Effects
Lithium side effects
Stages of lithium toxicity
Five most common side effects of carbamazepine
Management of common anticonvulsant mood stabilizer side effects (non-placeboadjusted rates)
Management of lithium side effects
Potential risk factors for antidepressant-induced mania (AIM) or cycling
Drug-Drug Interactions
Drug-drug interactions with lithium
Drug-drug interactions with carbamazepine (CBZ)
Drug-drug interactions with valproate
Drug-drug interactions with lamotrigine
Potentiating Maneuvers
Augmenting strategies in treating patients with bipolar disorder
Use in Special Populations
Use of mood stabilizers in special populations
Questions and Answers
Indications
Mechanisms of Action
Pharmacokinetics
Main Side Effects
Drug-Drug Interactions
Potentiating Maneuvers
Use in Special Populations
Vignettes/Puzzlers
References
CME Questions and Answers
Index

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