DNA Repair and Mutagenesis

ISBN-10: 1555813194
ISBN-13: 9781555813192
Edition: 2nd 2006 (Revised)
List price: $99.95 Buy it from $58.02
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Description: Featuring more than 10,000 references and lavishly complemented by over 700 high-quality illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors,  More...

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Book details

List price: $99.95
Edition: 2nd
Copyright year: 2006
Publisher: ASM Press
Publication date: 11/22/2005
Binding: Hardcover
Pages: 1118
Size: 9.00" wide x 11.25" long x 2.00" tall
Weight: 6.710

Featuring more than 10,000 references and lavishly complemented by over 700 high-quality illustrations, DNA Repair and Mutagenesis, 2nd Edition, is a timely update to the original edition published in 1995. The addition of three new authors, including an expert in the field of structural biology, ensures a comprehensive review of the most current research in diverse subject areas. An ideal textbook for advanced undergraduate and graduate students, the book is also an essential resource for all scientists researching cellular responses to DNA damage. Completely reorganized, the new edition presents a significant overhaul of the existing chapters and introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. As with the first edition, this new volume presents the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. The book consists of 30 chapters divided into five main parts, covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage. Basic principles are appropriately stressed; however, the book focuses on the significant progress to date and future research directions.

Richard D. Wood is an Honorary Research Fellow in the Civil and Computational Engineering Centre at Swansea University. He has over 20 years experience of teaching the course Nonlinear Continuum Mechanics for Finite Element Analysis at Swansea University, which he originally developed at the University of Arizona and also taught at IIT Roorkee, India and the Institute of Structural Engineering at the Technical University in Graz. Dr Wood's academic career has focused on finite element analysis, and he has written over 60 papers in international journals, and many chapter contributions, on topics related to nonlinear finite element analysis.

Introduction : biological responses to DNA damage
DNA damage
Introduction to mutagenesis
Reversal of base damage caused by UV radiation
Reversal of alkylation damage in DNA
Base excision repair
Nucleotide excision repair : general features and the process in prokaryotes
Nucleotide excision repair in eukaryotes : cell biology and genetics
Mechanism of nucleotide excision repair in eukaryotes
Heterogeneity of nucleotide excision repair in eukaryotic genomes
Alternative excision repair of DNA
Mismatch repair
Repair of mitochondrial DNA damage
The SOS responses of prokaryotes to DNA damage
Mutagenesis and translesion synthesis in prokaryotes
Recombinational repair, replication fork repair, and DNA damage tolerance
DNA damage tolerance and mutagenesis in eukaryotic cells
Managing DNA strand breaks in eukaryotic cells : repair pathway overview and homologous recombination
Managing DNA strand breaks in eukaryotic cells : nonhomologous end joining and other pathways
Cell cycle checkpoints : general introduction and mechanisms of DNA damage sensing
Cell cycle checkpoints : signal transmission and effector targets
Transcriptional responses to DNA damage
DNA damage and the regulation of cell fate
Xeroderma pigmentosum : a disease associated with defective nucleotide excision repair or defective translesion DNA synthesis
Other diseases associated with defects in nucleotide excision repair of DNA
Diseases associated with defective responses to DNA strand breaks
Diseases associated with disordered DNA helicase function
Additional diseases associated with defective responses to DNA damage
Hereditary diseases that implicate defective responses to DNA damage
DNA polymorphisms in gatekeeper and guardian genes

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