Antibiotics Actions, Origins, Resistance

Name: Antibiotics Actions, Origins, Resistance
Price: 132.9 USD
Availability: InStock
ISBN: 9781555812546

ISBN-10: 1555812546

ISBN-13: 9781555812546

Edition: 2003

Authors: Christopher Walsh

List price: $99.95

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As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation.

Book details

List price: $99.95
Copyright year: 2003
Publisher: ASM Press
Publication date: 2/11/2003
Binding: Hardcover
Pages: 335
Size: 7.25" wide x 10.00" long x 1.00" tall
Weight: 1.738



Preface


Introduction to Antibiotics


Antibiotics: Initial Concepts


Validated Targets and Major Antibiotic Classes


Introduction to Major Antibiotic Classes and Modes of Action


Antibiotics That Act on Cell Wall Biosynthesis


Antibiotics That Block Bacterial Protein Biosynthesis


Antibiotics That Block DNA Replication and Repair: the Quinolones


Other Targets of Antibacterial Drugs


Antibiotic Resistance


Natural and Producer Immunity versus Acquired Resistance


Enzymatic Destruction or Modification of the Antibiotic by Resistant Bacteria


Antibiotic Resistance by Efflux Pumps


Antibiotic Resistance by Replacement or Modification of the Antibiotic Target


Antibiotic Biosynthesis


Regulation of Antibiotic Biosynthesis in Producer Organisms


Polyketide Antibiotic Biosynthesis: Assembly-Line Enzymology


Enzymatic Assembly Lines for Nonribosomal Peptide Antibiotics


Biosynthesis of Other Classes of Antibiotics


New Strategies for Finding Novel Antibiotics and Extending Their Lifetimes


New Looks at Targets


New Molecules


Contexts and Challenges for the Use of New Antibiotics


References


Index