Immunology, Infection, and Immunity

ISBN-10: 1555812465
ISBN-13: 9781555812461
Edition: 2004
List price: $99.95
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Description: The basic molecular & cellular components of the immune system are examined, relative to the pathogenisis & prevention of infectious diseases. With contributions from multiple areas of immunology, this text offers current information in a rapidly  More...

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Book details

List price: $99.95
Copyright year: 2004
Publisher: ASM Press
Publication date: 4/8/2004
Binding: Hardcover
Pages: 718
Size: 9.00" wide x 11.25" long x 1.50" tall
Weight: 4.4
Language: English

The basic molecular & cellular components of the immune system are examined, relative to the pathogenisis & prevention of infectious diseases. With contributions from multiple areas of immunology, this text offers current information in a rapidly moving field.

Contributors
Preface
About the Editors
Function and Composition of the Immune System
Overview of Immunity
Overview of Immunology
Innate Immunity
Mechanisms of Adaptive Immunity
Interactions between Acquired and Innate Immunity
Summary
Suggested Reading
Innate Immunity
Physical and Physiologic Barriers
Enzymatic and Protein Effectors
Cellular Effectors of Innate Immunity
Innate Responses to Viral Infection
Inflammation: Orchestrating the Innate Effectors
Cross-Talk between the Innate and Acquired Arms of Immunity
Summary
Suggested Reading
Cells of the Immune System
Hematopoiesis and Generation of Cells of the Immune System
Identification of Cells via Surface Markers
Morphology and Function of Myeloid Cells
Morphology and Function of Lymphoid Cells
Major Populations and Subpopulations of Lymphocytes
Summary
Suggested Reading
Organs and Tissues of the Immune System
Generative Lymphoid Organs
The Anatomy of Immune Responses
Peripheral Lymphoid Organs
MALT
Cutaneous Immunity
Summary
Suggested Reading
Complement
Complement Proteins
Activation of Complement
Functions of Complement
Regulation of Complement Activation
Synthesis of Complement Proteins
Disorders Associated with Defects in Synthesis of Complement Proteins
Summary
Suggested Reading
Antibodies
Antibodies
Chemical Structure of Antibodies
Classification of Antibodies
The Immunoglobulin Superfamily
Suggested Reading
Molecular Genetics of Antibody Diversity
Observations and Theories Predating Molecular Genetics of Immunoglobulin Genes
Organization of the Immunoglobulin Genes
The Mechanism of Variable-Region Gene Assembly
Generation of Antibody Diversity
Productive and Nonproductive Rearrangements: Allelic Exclusion
B-Cell Differentiation
Regulation of Immunoglobulin Expression
An AID in the Generation of Immunoglobulin Diversity
Summary
Suggested Reading
Antigens, Antigenicity, and Immunogenicity
General Properties of Antigens
Activation of T Cells and B Cells by Antigen
Antigenicity and Immunogenicity
Adjuvants
Important Antigens from Infectious Agents
Superantigens
Mitogens
Summary
Suggested Reading
Antibody-Antigen Interactions and Measurements of Immunologic Reactions
The Concept of Specificity
Deviations from Absolute Specificity
The Physical Nature of the Antibody-Antigen Interaction
The Law of Mass Action and Its Application to Antigen-Antibody Binding
Types of Assays To Measure Antigen-Antibody Interactions
Use of Antibodies To Differentiate Tissues and Cells
Measurements of Immunity to Infection
Measurements of Cell-Mediated Immunity
Summary
Suggested Reading
B-Lymphocyte Activation and Antibody Production
Interaction of Antigen and B Lymphocyte: the BCR
Regulation of BCR Signal Transduction
Germinal Centers and B-Cell Maturation
Interaction of B Cells with FDCs
Antibody Production by B Lymphocytes
TI Antibody Response
TD Antibody Response
B-Lymphocyte Interaction with T Lymphocytes
Effect of Cytokines on B-Cell Activation and Antibody Production
Isotype Switching
Apoptosis: the Flip Side of B-Cell Activation
Summary
Suggested Reading
Cellular Immunity
The Major Histocompatibility Complex
Discovery of the MHC Gene Complex
General Arrangement of the MHC Gene Complex
Basic Nomenclature of MHC Genes and Proteins
Use of Inbred Mouse Strains in Experimental Immunology
Structure of MHC Class I and Class II Proteins
Peptide Binding by MHC Class I and Class II Proteins
Serologic and Sequence-Based Identification of MHC Proteins and Relationship to MHC Polymorphism
MHC Proteins with Ancillary Roles in Antigen Presentation
MHC Class III: MHC Proteins with No Role in Antigen Presentation
Roles of Some Nonclassical MHC Gene Products in Activation of T Cells in Response to Novel Stimuli
MHC-Like Antigen-Presenting Molecules Encoded by Genes Located outside the MHC and Roles in Presentation of Unusual Antigens
Summary
Suggested Reading
Antigen Processing and Presentation
APCs
Antigen-Processing Pathways
Antigen Presentation by MHC Class I
Antigen Presentation by MHC Class II
Presentation of Nonclassical, Nonprotein Antigens to T Cells
Summary
Suggested Reading
The T-Cell Receptor
Isolation and Characterization of the TCR
Structure of the TCR
Organization of TCR Genes
Generation of Diversity in the TCR
Production of a Functional Receptor
Summary
Suggested Reading
T-Cell Maturation and Activation
T-Cell Maturation and Development in the Thymus
Tolerance
T-Cell Activation and Antigen Recognition
Summary
Suggested Reading
Cellular Communication
Interaction of Cells of the Immune System
Soluble Mediators of Communication: Cytokines and Chemokines
Cytokine Families
Role of Cytokines in Other Diseases
Summary
Suggested Reading
Immunologic Effector Systems and Immunity to Infection
Cell-Mediated Immunity
Fundamental Aspects of Cell-Mediated Immunity
Initiating Cell-Mediated Immunity
DTH Reactions
Cell-Mediated Cytotoxicity
CTLs
ADCC
Summary
Suggested Reading
Mucosal Immunity
GALT
Airway Immunity: BALT
Urogenital Tract Immunity
Damage to Mucosal Sites by the Immune Response
Summary
Suggested Reading
Immunity to Bacterial Infections
Bacteria and Disease
Immune System Function and Resistance to Bacterial Infections
The Study of How Bacteria Cause Disease: Bacterial Pathogenesis
Initial Stage of Bacterial Infection: Colonization of Host Surfaces
Tissue Invasion and Disease
Bacterial Virulence Factors: How They Thwart Host Immunity
Bioterrorism and Bacterial Pathogens
Antigenic Targets Involved in Protective Immunity
Summary
Suggested Reading
Immunity to Viruses
Viruses and Disease
Viruses and Acquired Immunity
Structural Properties of the Virus
Replication of the Virus
Evasion of Host Antiviral Immune Defenses
Summary
Suggested Reading
Immunity to Parasitic and Fungal Infections
Protozoal Infections
Helminthic Infections
Immune Responses in Parasitic Infections
Immune Effectors in Parasitic Infections
Immune Evasion by Parasites
Immunology of Fungal Infections
Summary
Suggested Reading
Vaccines and Vaccination
Early and Defining Issues in Vaccine Development
Basic Concepts in Vaccination
Immune Recognition of Pathogens
Vaccine Components and Vaccination Strategies
Bacterial Vaccines
Viral Vaccines
Vaccines for Fungal Infections
Vaccines for Parasitic Diseases
Passive Immunization
Summary
Suggested Reading
Immune System Dysfunction: Deficiencies
Immunology and AIDS
Etiology and Epidemiology of AIDS
The Viral Genome
Pathogenesis
Immune Defects Due to HIV-1 Infection
Immune Responses to HIV-1 Infection
Evasion of Immune Responses by HIV-1
Pharmacologic Therapy for HIV-1 Infection
Potential Vaccines and Immunotherapies for HIV-1 Infection
Summary
Suggested Reading
Clinical and Genetic Perspectives in Primary Immunodeficiency Disorders
Basic Defects Leading to Immune Dysfunction
Clinical Manifestations of Immunodeficiency
Respiratory Tract Infection
Skin Manifestations of Immune Deficiency
Oral Manifestations of Immune Deficiency
Viral Illnesses or Vaccine Complications of Unusual Severity
Summary
Suggested Reading
Cancer and the Immune System
Cancer Is a Disease of Genes
The Immune Response to Cancer
Mechanisms of Antitumor Immunity
Immune Cell Types Important in Antitumor Immunity
Tumor Surveillance Theory
Tumor Immunotherapy
Summary
Suggested Reading
Immune System Dysfunction: Overactivity
Hypersensitivity
Historical Understanding of the Concept of Hypersensitivity
Subtypes of Allergic Responsiveness
Summary
Suggested Reading
Autoimmunity and Disease
Autoimmunity and Autoimmune Disease
Targets of Autoimmune Diseases
Pathogenesis of Autoimmune Diseases
Animal Models of Autoimmune Diseases
Etiology of Autoimmunity
Therapy for Autoimmune Diseases
Summary
Suggested Reading
Transplantation Immunology
The Role of Major Histocompatibility Antigens versus Minor Histocompatibility Antigens in Transplantation
Tissue Typing
Initiation of a Graft Rejection Response
T-Cell Activation
Effector Mechanisms of Allograft Rejection
Chemokines
Graft-versus-Host Disease
Tolerance
Immunosuppression
Classes of Immunosuppressive Drugs
Summary
Suggested Reading
CD Antigens
Antigen Names with CD Designation Equivalents
Cytokines, Chemokines, and Their Receptors
Cell Types and Immune-Related Functions
Historical Timeline of Immunology
Time Course of a Typical Immune Response
Comparison of Relative Sizes of Cells, Structures, and Molecules That Are Relevant to Infection and Immunity
Index

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