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| Acknowledgments | |
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| Preface | |
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| Prologue | |
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| About the Author | |
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| Introduction | |
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| What Is Biostatistics? | |
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| What Are the Issues? | |
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| Summary | |
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| Study Designs | |
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| Vocabulary | |
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| Observational Study Designs | |
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| Randomized Study Designs | |
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| The Framingham Heart Study | |
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| More on Clinical Trials | |
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| Sample Size Implications | |
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| Summary | |
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| Practice Problems | |
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| Quantifying the Extent of Disease | |
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| Prevalence | |
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| Incidence | |
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| Relationships Between Prevalence and Incidence | |
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| Comparing the Extent of Disease Between Groups | |
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| Summary | |
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| Practice Problems | |
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| Summarizing Data Collected in the Sample | |
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| Dichotomous Variables | |
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| Ordinal and Categorical Variables | |
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| Continuous Variables | |
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| Summary | |
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| Practice Problems | |
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| The Role of Probability | |
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| Sampling | |
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| Basic Concepts | |
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| Conditional Probability | |
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| Independence | |
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| Bayes' Theorem | |
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| Probability Models | |
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| Summary | |
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| Practice Problems | |
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| Confidence Interval Estimates | |
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| Introduction to Estimation | |
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| Confidence Intervals for One Sample, Continuous Outcome | |
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| Confidence Intervals for One Sample, Dichotomous Outcome | |
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| Confidence Intervals for Two Independent Samples, Continuous Outcome | |
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| Confidence Intervals for Matched Samples, Continuous Outcome | |
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| Confidence Intervals for Two Independent Samples, Dichotomous Outcome | |
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| Summary | |
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| Practice Problems | |
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| Hypothesis Testing Procedures | |
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| Introduction to Hypothesis Testing | |
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| Tests with One Sample, Continuous Outcome | |
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| Tests with One Sample, Dichotomous Outcome | |
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| Tests with One Sample, Categorical and Ordinal Outcomes | |
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| Tests with Two Independent Samples, Continuous Outcome | |
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| Tests with Matched Samples, Continuous Outcome | |
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| Tests with Two Independent Samples, Dichotomous Outcome | |
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| Tests with More Than Two Independent Samples, Continuous Outcome | |
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| Tests for Two or More Independent Samples, Categorical and Ordinal Outcomes | |
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| Summary | |
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| Practice Problems | |
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| Power and Sample Size Determination | |
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| Issues in Estimating Sample Size for Confidence Intervals Estimates | |
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| Issues in Estimating Sample Size for Hypothesis Testing | |
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| Summary | |
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| Practice Problems | |
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| Multivariable Methods | |
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| Confounding and Effect Modification | |
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| The Cochran-Mantel-Haenszel Method | |
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| Introduction to Correlation and Regression Analysis | |
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| Multiple Linear Regression Analysis | |
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| Multiple Logistic Regression Analysis | |
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| Summary | |
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| Practice Problems | |
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| Nonparametric Tests | |
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| Introduction to Nonparametric Testing | |
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| Tests with Two Independent Samples | |
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| Tests with Matched Samples | |
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| Tests with More Than Two Independent Samples | |
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| Summary | |
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| Practice Problems | |
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| Survival Analysis | |
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| Introduction to Survival Data | |
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| Estimating the Survival Function | |
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| Comparing Survival Curves | |
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| Cox Proportional Hazards Regression Analysis | |
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| Extensions | |
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| Summary | |
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| Practice Problems | |
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| Appendix | |
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| Glossary | |
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| Index | |