Cancer Basic Science and Clinical Aspects

ISBN-10: 1405156066
ISBN-13: 9781405156066
Edition: 2010
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Book details

Copyright year: 2010
Publisher: John Wiley & Sons, Limited
Publication date: 12/18/2009
Binding: Paperback
Pages: 424
Size: 7.00" wide x 9.50" long x 0.75" tall
Weight: 2.222
Language: English

Preface
Acknowledgements
The basics of cancer
Cancer is a complex entity
Cancer through the ages
Modem day cancer research and treatment
Prevalence and mortality varies with each cancer
Risk factors have been identified
Will cancer be conquered within our lifetime?
Cells: The fundamental unit of life
Seven hierarchal levels of organization
Four types of macromolecular polymers
Cell structure and function
Relationship between structure and function is important
The human genome and protein function
The composition and function of the human genome
Having a diploid genome has its advantages
Proteins carry out diverse functions
Cell cycle, oncogenes, and tumor suppressor genes
Cell division in germ-line and somatic tissues
Consequences of germ-line and somatic tissue mutations
Cell division, differentiation, and maturation occur to form functional tissues
Cell division is under the regulation of the cell cycle
Loss of cell cycle control results in uncontrolled cell growth
Tumor formation, growth, and metastasis
Tissue changes that occur in response to stimuli
Feeding tumor growth by angiogenesis
Characteristics of benign and malignant tumors
Events that occur during the process of metastasis
Cancer screening, detection and diagnostic procedures and tests
Factors that determine the accuracy of a diagnostic test or procedure
Common screening tests
Diagnostic procedures for the confirmation of a disease
Tumor grade and stage factor into the type of treatment regimen and prognosis
Cancer treatment modalities
Surgery: the oldest and most commonly used treatment method
Radiation kills by causing extensive DNA damage
Cytotoxic effects of chemotherapeutic drugs
Side effects and risks from the use of cytotoxic drugs
Hormonal deprivation treatment: used for estrogen- and androgen-dependent cancers
Can cancer growth be controlled by inhibiting angiogenesis?
Additional enzymes targeted for inhibition
Biological therapy stimulates the body's ability to fight cancer
Breast cancer
Breast cancer statistics
Women's breast tissue: unique in structure and function
Causes of breast cancer
Regular examinations of the breast are important for early diagnosis
What follows a positive diagnosis?
Treatment options are unique for each individual
Much has been accomplished, more needs to be done
Ovarian cancer
Ovarian cancer statistics
Structure and function of ovaries
There are three tissue categories of ovarian cancer
Symptoms of overian cancer are vague and often missed
Certain factors have been associated with a higher risk
Diagnostic tools are available but not always used or recommended
Additional procedures are necessary to confirm suspicious results or if there is metastasis
The FIGO system may be used to stage ovarian cancer
Treatment options for ovarian cancer
Steps are taken to prevent recurrence but do not always work when the cancer is advanced
Much needs to be done in the future
Cervical cancer
Cervical cancer statistics
Structure and function of the cervix
Symptoms of cervical cancer
Pelvic examinations and Pap tests enable early detection
Risk factors for cervical cancer
The HPV test is a vital diagnostic tool
Additional tests are necessary to examine the cervix
Treatment depends on the stage
A vaccine will prevent many cases of cervical cancer
Prostate cancer
Prostate cancer statistics
Function of the prostate gland
Certain factors influence the development of prostate cancer
Symptoms of an enlarged prostate
Screening and diagnostic tests for prostate cancer
There are traditional and unique treatment options available
Prostate cancer mortality rates have decreased
Much attention is being given to the number one cancer affecting men
Testicular cancer
Testicular cancer statistics
Structure and function of testicles
There are three types of testicular tumors
Risk factors for the disease
Symptoms of testicular cancer
Testicular self-examination (TSE) is recommended
Blood and imaging tests are used to determine diagnosis and possible metastasis
Testicular cancer treatment results in a high cure rate
Causes and treatments are being studied
Skin cancer
Skin cancer statistics
Structure and function of the skin
Three types of skin cancer
Risk factors for developing skin cancer
Methods used to screen for skin cancer
Surgery and chemotherapy are standard treatments for metastatic skin cancer
What happens after skin cancer treatment
Limited UV radiation exposure is the number one form of prevention
Lung cancer
Lung cancer statistics
Lungs are the site of the exchange of gases
Risk factors associated with the development of lung cancer
Lack of distinctive symptoms makes early diagnosis difficult
Lung cancer is often diagnosed at an advanced stage
There are two main categories of lung cancer
Three traditional therapies are used in lung cancer treatment
Is there discrimination in cancer research funding?
Colorectal cancer
Colon and rectum are the last two sections of the gastrointestinal tract
Risk factors for colorectal cancer
Screening tests
Treatment options
Targeted therapies
Screening tests performed after the course of treatment
Leukemia and lymphoma
Leukemia statistics
Leukemia is a cancer of the blood cells
The exact cause of leukemia is unknown
Early symptoms of leukemia
Laboratory studies are necessary to determine the diagnosis
There are many types of leukemia
Nonchemotherapeutic treatment options have significantly improved survival rates
Lymphoma is a malignancy of the lymphatic system
Hodgkin's vs. non-Hodgkin's lymphoma
Certain risk factors are associated with an increased incidence of lymphoma
Diagnosing lymphoma involves biopsies and imaging tests
Lymphomas must be classified to determine appropriate treatment
Treatment options depend on the type of lymphoma, stage, and extent of metastasis
Glossary
Index

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