Cellular Physiology of Nerve and Muscle

ISBN-10: 1405103302
ISBN-13: 9781405103305
Edition: 4th 2002 (Revised)
Authors: Gary G. Matthews
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Description: Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the  More...

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Book details

List price: $100.95
Edition: 4th
Copyright year: 2002
Publisher: John Wiley & Sons, Incorporated
Publication date: 11/22/2002
Binding: Paperback
Pages: 248
Size: 7.50" wide x 10.00" long x 0.50" tall
Weight: 1.298
Language: English

Cellular Physiology of Nerve and Muscle, Fourth Edition offers a state of the art introduction to the basic physical, electrical and chemical principles central to the function of nerve and muscle cells. The text begins with an overview of the origin of electrical membrane potential, then clearly illustrates the cellular physiology of nerve cells and muscle cells. Throughout, this new edition simplifies difficult concepts with accessible models and straightforward descriptions of experimental results. An all-new introduction to electrical signaling in the nervous system. Expanded coverage of synaptic transmission and synaptic plasticity. A quantitative overview of the electrical properties of cells. New detailed illustrations.

Preface
Acknowledgments
Origin of Electrical Membrane Potential
Introduction to Electrical Signaling in the Nervous System
The Patellar Reflex as a Model for Neural Function
The Cellular Organization of Neurons
Electrical Signals in Neurons
Transmission between Neurons
Composition of Intracellular and Extracellular Fluids
Intracellular and Extracellular Fluids
The Structure of the Plasma Membrane
Summary
Maintenance of Cell Volume
Molarity, Molality, and Diffusion of Water
Osmotic Balance and Cell Volume
Answers to the Problem of Osmotic Balance
Tonicity
Time-course of Volume Changes
Summary
Membrane Potential: Ionic Equilibrium
Diffusion Potential
Equilibrium Potential
The Nernst Equation
The Principle of Electrical Neutrality
The Cell Membrane as an Electrical Capacitor
Incorporating Osmotic Balance
Donnan Equilibrium
A Model Cell that Looks Like a Real Animal Cell
The Sodium Pump
Summary
Membrane Potential: Ionic Steady State
Equilibrium Potentials for Sodium, Potassium, and Chloride
Ion Channels in the Plasma Membrane
Membrane Potential and Ionic Permeability
The Goldman Equation
Ionic Steady State
The Chloride Pump
Electrical Current and the Movement of Ions Across Membranes
Factors Affecting Ion Current Across a Cell Membrane
Membrane Permeability vs. Membrane Conductance
Behavior of Single Ion Channels
Summary
Cellular Physiology of Nerve Cells
Generation of Nerve Action Potential
The Action Potential
Ionic Permeability and Membrane Potential
Measuring the Long-distance Signal in Neurons
Characteristics of the Action Potential
Initiation and Propagation of Action Potentials
Changes in Relative Sodium Permeability During an Action Potential
Voltage-dependent Sodium Channels of the Neuron Membrane
Repolarization
The Refractory Period
Propagation of an Action Potential Along a Nerve Fiber
Factors Affecting the Speed of Action Potential Propagation
Molecular Properties of the Voltage-sensitive Sodium Channel
Molecular Properties of Voltage-dependent Potassium Channels
Calcium-dependent Action Potentials
Summary
The Action Potential: Voltage-clamp Experiments
The Voltage Clamp
Measuring Changes in Membrane Ionic Conductance Using the Voltage Clamp
The Squid Giant Axon
Ionic Currents Across an Axon Membrane Under Voltage Clamp
The Gated Ion Channel Model
Membrane Potential and Peak Ionic Conductance
Kinetics of the Change in Ionic Conductance Following a Step Depolarization
Sodium Inactivation
The Temporal Behavior of Sodium and Potassium Conductance
Gating Currents
Summary
Synaptic Transmission at the Neuromuscular Junction
Chemical and Electrical Synapses
The Neuromuscular Junction as a Model Chemical Synapse
Transmission at a Chemical Synapse
Presynaptic Action Potential and Acetylcholine Release
Effect of Acetylcholine on the Muscle Cell
Neurotransmitter Release
The Vesicle Hypothesis of Quantal Transmitter Release
Mechanism of Vesicle Fusion
Recycling of Vesicle Membrane
Inactivation of Released Acetylcholine
Recording the Electrical Current Flowing Through a Single Acetylcholine-activated Ion Channel
Molecular Properties of the Acetylcholine-activated Channel
Summary
Synaptic Transmission in the Central Nervous System
Excitatory and Inhibitory Synapses
Excitatory Synaptic Transmission Between Neurons
Temporal and Spatial Summation of Synaptic Potentials
Some Possible Excitatory Neurotransmitters
Conductance-decrease Excitatory Postsynaptic Potentials
Inhibitory Synaptic Transmission
The Synapse between Sensory Neurons and Antagonist Motor Neurons in the Patellar Reflex
Characteristics of Inhibitory Synaptic Transmission
Mechanism of Inhibition in the Postsynaptic Membrane
Some Possible Inhibitory Neurotransmitters
The Family of Neurotransmitter-gated Ion Channels
Neuronal Integration
Indirect Actions of Neurotransmitters
Presynaptic Inhibition and Facilitation
Synaptic Plasticity
Short-term Changes in Synaptic Strength
Long-term Changes in Synaptic Strength
Summary
Cellular Physiology of Muscle Cells
Excitation-Contraction Coupling in Skeletal Muscle
The Three Types of Muscle
Structure of Skeletal Muscle
Changes in Striation Pattern on Contraction
Molecular Composition of Filaments
Interaction between Myosin and Actin
Regulation of Contraction
The Sarcoplasmic Reticulum
The Transverse Tubule System
Summary
Neural Control of Muscle Contraction
The Motor Unit
The Mechanics of Contraction
The Relationship Between Isometric Tension and Muscle Length
Control of Muscle Tension by the Nervous System
Recruitment of Motor Neurons
Fast and Slow Muscle Fibers
Temporal Summation of Contractions Within a Single Motor Unit
Asynchronous Activation of Motor Units During Maintained Contraction
Summary
Cardiac Muscle: The Autonomic Nervous System
Autonomic Control of the Heart
The Pattern of Cardiac Contraction
Coordination of Contraction Across Cardiac Muscle Fibers
Generation of Rhythmic Contractions
The Cardiac Action Potential
The Pacemaker Potential
Actions of Acetylcholine and Norepinephrine on Cardiac Muscle Cells
Summary
Derivation of the Nernst Equation
Derivation of the Goldman Equation
Electrical Properties of Cells
Suggested Readings
Index

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