Primer of Population Genetics

ISBN-10: 0878933042

ISBN-13: 9780878933044

Edition: 3rd 2000 (Revised)

Authors: Daniel L. Hartl

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Description:

The text provides a concise but comprehensive introduction to population genetics. The chapters of the book address genetic variation, the causes of evolution, molecular population genetics and the genetic architecture of complex traits.
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Book details

List price: $61.95
Edition: 3rd
Copyright year: 2000
Publisher: Sinauer Associates, Incorporated
Publication date: 10/6/1999
Binding: Paperback
Pages: 221
Size: 6.25" wide x 9.00" long x 0.50" tall
Weight: 0.990
Language: English

Preface
Acronyms and Abbreviations
Genetic Variation
Genetic and Molecular Essentials
Genotype and Phenotype
Gene Expression
DNA Cleavage, Manipulation, and Amplification
Types of Polymorphisms
DNA Polymorphisms
Uses of DNA Polymorphisms
Protein Polymorphisms
Gene and Genotype Frequencies
Organization of Genetic Variation
Populations
Models
Random Mating
The Hardy-Weinberg Principle
Implications of Random Mating
Chi-square Test for HWE
Recessive Alleles Hidden in Heterozygotes
Multiple Alleles and X-Linked Genes
Multiple Loci: Linkage and Linkage Disequilibrium
Inbreeding
Genotype Frequencies with Inbreeding
The Inbreeding Coefficient
Inbeeding Depression
Calculation of the Inbreeding Coefficient from Pedigrees
Regular Systems of Mating
Further Readings
Problems
The Causes of Evolution
Mutation
Forward Mutation
Reversible Mutation
Remote Inbreeding in a Finite Population
Equilibrium Heterozygosity with Mutation
Migration
The Island Model of Migration
How Migration Limits Genetic Divergence
Wahlund's Principle
Hierarchical Population Structure
Natural Selection
Haploid Selection
Diploid Selection
Time Required for Changes in Gene Frequency
Overdominance and Underdominance
Mutation-Selection Balance
More Complex Modes of Selection
Random Genetic Drift
Diffusion Approximations
Probability of Fixation and Time to Fixation
Effective Population Number
Further Readings
Problems
Molecular Population Genetics
Molecular Polymorphisms
The Information Content of Molecular Sequences
The Coalescent
Nucleotide Polymorphism
Nucleotide Diversity
Tajima's D Statistic
Patterns of Change in Nucleotide and Amino Acid Sequences
Synonymous and Nonsynonymous Substitutions
Codon Usage Bias
Selection for Optimal Codons and Amino Acids
Selective Sweeps versus Background Selection
Polymorphism and Divergence
The Hudson-Kreitman-Aguade (HKA) Test
The McDonald-Kreitman Test
Polymorphism and Divergence in a Poisson Random Field
Convergence to Adaptation
Molecular Phylogenetics
The Multiple-Hit Problem
Phylogenetic Inference
Molecular Clocks
Transposable Elements
Insertion Sequences and Transposons in Bacteria
Transposable Elements in Eukaryotes
Further Readings
Problems
The Genetic Architecture of Complex Traits
Types of Complex Traits
Phenotypic Variation
Genetics and Environment
Genotypic Variance and Environmental Variance
Broad-Sense Heritability
Genotype-Environment and Other Interactions
Genetic Effects on Complex Traits
Components of Genotypic Variation
Artificial Selection
Prediction Equation for Individual Selection
Genetic Basis of Complex Traits
Change in Allele Frequency
Change in Mean Phenotype
Correlation between Relatives
Parent-Offspring Correlation
Heritability Estimates from Resemblance between Relatives
Offspring-on-Parent Regression
Quantitative Genetics of Natural Populations
Directional Selection with Mutation-Selection-Drift
Stabilizing Selection with Mutation-Selection-Drift
Antagonistic Pleiotropy
Complex Traits with Discrete Expression
Threshold Traits: Genes as Risk Factors
Heritability of Liability
Applications to Human Disease
Linkage Analysis and Lod Scores
Quantitative Trait Loci (QTLs)
Number of Genes
QTL Mapping
Candidate Genes
Further Readings
Problems
Literature Cited
Index
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