Cellular Signal Processing An Introduction to the Molecular Mechanisms of Signal Transduction

ISBN-10: 0815342152
ISBN-13: 9780815342151
Edition: 2008
List price: $145.00 Buy it from $68.44
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Description: Cellular Signal Processing presents the essential concepts underlying cell signaling. It is based on a unifying principle that traces cell signaling to biochemical switching reactions that link protein-protein interactions with energy production.  More...

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Book details

List price: $145.00
Copyright year: 2008
Publisher: Taylor & Francis Group
Publication date: 11/14/2008
Binding: Paperback
Pages: 656
Size: 8.25" wide x 11.25" long x 0.75" tall
Weight: 2.794
Language: English

Cellular Signal Processing presents the essential concepts underlying cell signaling. It is based on a unifying principle that traces cell signaling to biochemical switching reactions that link protein-protein interactions with energy production. Designed for use by undergraduate and graduate students in cell biology, biochemistry, and pharmacology courses, as well as medical students, it examines the cell as a data processing unit in which the proteins form an extremely complex and ever-changing network of interactions. The book emphasizes the evolutionary aspects of cell signaling and illuminates the analogies in communication among cellular, neuronal, and data-processing mechanisms. Features include a unique chapter on prokaryotic signal processing, discussion of the clinical aspects of cell signaling in health and disease, and an illustration program that highlights the major concepts.

Friedrich Marks, PhD, is Professor of Biochemistry at the University of Heidelberg and Emeritus Department head, German Cancer Research Center. Dr. Marks has been teaching biochemistry, in particular signal transduction, for more than 30 years. His research has focused on the role of signaling reactions in tumor development.Ursula Klingm�¼ller, PhD, is a lecturer at the University of Heidelberg and Head of the Systems Biology of Signal Transduction Division, German Cancer Research Center. Dr. Klingm�¼llerâ��s research focuses on systems biology of signal transduction and dynamic pathway modeling.Karin M�¼ller-Decker, PhD, is a lecturer at the University of Heidelberg and Head of the Tumor Models Units, German Cancer Research Center. Dr. M�¼ller-Decker is conducting pioneering work on eicosanoid signaling in tumor development.

The "Brain of the Cell": Data Processing by Protein Networks
Supplying the Network with Energy: Basic Biochemistry of Signal Transduction
Evolution of Cellular Data Processing
Basic Equipment: G-Proteins, Second Messengers, and Protein Kinases
Signal Transduction by Receptors with Seven Transmembrane Domains
Signal Transduction by Serine/Threonine Kinase-Coupled Receptors
Signal Transduction by Tyrosine Kinase- and Protein Phosphatase-Coupled Receptors: A Late Invention of Evolution
Gene Transcription: The Ultimate Target of Signal Transduction
Signals Controlling mRNA Translation
Signal Transduction by Small G-Proteins: The Art of Molecular Targeting
Mitogen-activated Protein Kinase and Nuclear Factor [kappa]B Modules
Cancer and Regulation of Cell Division
Signal Transduction by Proteolysis and Programmed Cell Death
Signal Transduction by Ions
Sensory Signal Processing
Signaling at Synapses: Neurotransmitters and their Receptors
Putting Together the Pieces: The Approach of Systems Biology
Index

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