Molecular Biology of the Gene

ISBN-10: 080534635X
ISBN-13: 9780805346350
Edition: 5th 2004 (Revised)
List price: $129.00
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Description: Every student package automatically includes a CD-ROM and access to a website containing tutorials, molecular models, and more. The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene , has been thoroughly  More...

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Book details

List price: $129.00
Edition: 5th
Copyright year: 2004
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 12/23/2003
Binding: Mixed Media
Pages: 768
Size: 8.50" wide x 10.75" long x 1.00" tall
Weight: 4.488
Language: English

Every student package automatically includes a CD-ROM and access to a website containing tutorials, molecular models, and more. The long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene , has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double-helix. Though completely updated, the new edition retains the distinctive character of earlier editions that made it the most widely used book in molecular biology. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline. The completely new art is printed in full color for the first time. Divided into five parts, the first (Chemistry and Genetics) begins with an overview of molecular biology, placing the discipline in historical context and introducing the basic chemical concepts that underpin our description of molecular biology today. The second and third parts (Maintenance of the Genome and Expression of the Genome) form the heart of the book, describing in detail the basic mechanisms of DNA replication, transcription and translation. The fourth part of the book (Regulation) deals with how gene expression is regulated - from the examination of basic mechanisms that regulate gene expression in bacterial and eukaryotic systems, to a description of how regulation of gene expression lies at the heart of the process of development. Recent findings from sequencing whole genomes of several animals have revealed that they all share essentially the same genes. The last chapter in the regulation section looks at how changes in gene regulation can account for how different animals can be made up of the same genes. The final part of the book (Methods) deals with the techniques and methods used in molecular biology.

Michael Levine spent a total of 25 years working undercover for four federal agencies. As an agent for the Drug Enforcement Administration for 23 years, Levine would ultimately bring about the arrests of approximately 3,000 criminals, by posing as priests, Colombian and Puerto Rican drug merchants, and a mob leader. In this manner, he was able to corral millions of drug money dollars. As a Jew growing up in a Hispanic neighborhood in South Bronx, New York City, Levine grew up pretending to be Puerto Rican and speaking fluent Spanish. Despite a couple of pre-adulthood arrests, he joined the U.S. Air Force. Later came marriage and the earning of an accounting degree at Hofstra University, an education financed through tending bar and playing saxophone. After graduation, he moved to the U.S. Treasury Department; this was followed by a stint in the Bureau of Alcohol, Tobacco, and Firearms. Michael Levine survived impersonating drug dealers but he also faced the drug wars at home. He tried to get his brother David to kick the heroin habit by having him move into his home with Levine, his wife, and his family, but David would later commit suicide. Levine's daughter faced drug trouble as well. She was removed from the family through a court petition, but she later rejoined them. Michael Levine has chronicled life as a federal agent in such books as Deep Cover. He enjoys walks with his wife Laura Kavanu and dog in Ulster County, N.Y.

Chemistry and Genetics
The Mendelian View of the World
Nucleic Acids Convey Genetic Information
The Importance of Weak Chemical Interactions
The Importance of High-Energy Bonds
Weak and Strong Bonds Determine Macromolecular Structure
Maintenance of the Genome
The Structures of DNA and RNA
Chromosomes, Chromatin, and the Nucleosome
The Replication of DNA
The Mutability and Repair of DNA
Homologous Recombination at the Molecular Level
Site-Specific Recombination and Transposition of DNA
Expression of the Genome
Mechanisms of Transcription
RNA Splicing
Translation
The Genetic Code
Regulation
Gene Regulation in Prokaryotes
Gene Regulation in Eukaryotes
Gene Regulation during Development
Comparative Genomics and the Evolution of Diversity
Methods
Techniques of Molecular Biology
Model Organisms
Index

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