Nature of Disease Pathology for the Health Professions

ISBN-10: 0781753171
ISBN-13: 9780781753173
Edition: 2007
List price: $69.95
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Description: This textbook is based on the premise that students learn better when material is easy to read, lively, and engaging. The author's readable style easily guides you through the causes and consequences of common diseases and is punctuated by humor,  More...

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Book details

List price: $69.95
Copyright year: 2007
Publisher: Lippincott Williams & Wilkins
Publication date: 12/15/2006
Binding: Paperback
Pages: 739
Size: 8.50" wide x 11.00" long x 0.75" tall
Weight: 3.080
Language: English

This textbook is based on the premise that students learn better when material is easy to read, lively, and engaging. The author's readable style easily guides you through the causes and consequences of common diseases and is punctuated by humor, case studies, and absorbing tales from the history of medicine. You'll gain an understanding of pathology and the skills needed to use what you've learned in clinical settings, with just the right amount of scientific detail to meet your needs.

Dedication
Preface
Additional Learning Resources
User's Guide
Acknowledgments
Reviewers
Guide to Case Studies
General Pathology
The Nature of Disease: How to Think about Illness
The Nature of Disease
Bodily Structure and Function in Disease
Healthy Is Not the Same as Normal; Sick Is Not the Same as Abnormal
Defining Normal
The Extent of Abnormality
Test Sensitivity and Specificity
The Usefulness of Tests in Diagnosis
The Effect of Disease Prevalence on Test Usefulness
Initial Tests and Follow-up Tests
Disease and Diagnosis
Cell Injury, Adaptation, and Death
Back to Basics
The Origins of Cells and the Organization of Tissues
The Nucleus
The Cytoplasm
The Cell Membrane
The Cell Cycle
Cellular Communication
Biologic Aging
Cell Injury and Disease
Mild Cell Injury
Intracellular Accumulations
Adaptations of Cell Growth and Differentiation
Severe Cell Injury and Cell Death
Inflammation: The Reaction to Injury
The Inflammatory Response to Injury
The Cellular Response in Inflammation
The Vascular Response in Inflammation
Molecular Mediators of Inflammation
Acute Inflammation
The Pathogenesis of Acute Inflammation
The Anatomic Characteristics of Acute Inflammation
The Consequences of Acute Inflammation
Chronic Inflammation
The Pathogenesis of Chronic Inflammation
The Anatomic Characteristics of Chronic Inflammation
The Consequences of Chronic Inflammation
Distant Effects of Inflammation
Lymphangitis, Lymphadenitis, and Lymphadenopathy
Systemic Effects of Inflammation
The Inflammatory Response to Infection
Repair: Recovery from Injury
Definitions
Replacement of Injured Cells
The Importance of Tissue Structure
The Control of Cell Reproduction and Tissue Growth
Wound Healing and Fibrous Repair
Cell Migration into the Wound
The Growth of New Blood Vessels
Scar Development
Healing by First Intention
Healing by Second Intention
Abnormal Wound Healing
Host Factors Interfering with Wound Healing
Pathologic Wound Healing
Overview of Injury, Inflammation, and Repair
Disorders of Fluid Balance and Blood Flow
Back to Basics
Blood Pressure
Osmotic Pressure
The Circulation of Blood and Lymph
The Anatomy of Blood Vessels and Lymphatics
Body Water and Fluid Compartments
Edema
Low-protein Edema
High-protein Edema
Clinical Aspects of Edema
Hyperemia and Congestion
Hemorrhage, Thrombosis, and Embolism
Hemorrhage
Thrombosis
Embolism
Blood Flow Obstruction
Infarction
The Development of an Infarct
The Collapse of Circulation: Shock
Types of Shock
Stages of Shock
Neoplasms
The Language of Neoplasia
Types of Neoplasms
The Molecular and Genetic Basis of Neoplasia
Mutations
Cell Growth Control Genes
DNA Repair
The Causes of Cancer
The Structure of Neoplasms
The Gross Anatomy of Neoplasms
The Microscopic Anatomy of Neoplasms
Premalignant States and Conditions
The Biology of Neoplastic Growth
The Differentiation of Tumor Cells
Clones of Cells
The Speed of Tumor Growth
The Nourishment of Tumors
Tumor Cell Variation
The Spread of Neoplasms
The Immune Defense Against Neoplasia
The Epidemiology of Cancer
The Clinical Picture of Cancer
Clinical and Laboratory Assessment of Neoplasms
Clinical History
Obtaining Tissues and Cells for Diagnosis
Grading and Staging of Malignancies
Early Detection of Cancer
Tumor Markers
Developmental Genetic, and Pediatric Disease
Developmental Abnormalities
Embryologic Development
Congenital Malformations
Congenital Deformations
Genetic Disorders
Mutations
The Broad Influence of Genetics in Disease
Disease of Single Genes (Monogenic Disorders)
Disease Caused by Defective Dominant Autosomal Genes
Disease Caused by Defective Recessive Autosomal Genes
Disease Caused by Defective Genes on Sex Chromosomes
Clinical Expression of Single-Gene Defects
Cytogenetic Diseases
Disease Associated with Abnormal Numbers of Autosomes
Disease Associated with Abnormal Numbers of Sex Chromosomes
Genetic Diagnosis
Pediatric Diseases
Perinatal and Neonatal Disease
Intrauterine Growth Restriction
Prematurity
Birth Injury
Fetal and Newborn Infections
Infections in Children
Sudden Infant Death Syndrome (SIDS)
Hemolytic Disease of the Newborn (Erythroblastosis Fetalis)
Cystic Fibrosis
Tumors and Tumor-like Conditions of Children
Diseases of the Immune System
Back to Basics
Nonimmune Defense Mechanisms
The Normal Immune System
Immunity in Blood Transfusion
Classification of Immune Disease
Mechanisms of Immune Reaction
Immune Reaction: Immediate Hypersensitivity
Immune Reaction: Cytotoxic Hypersensitivity
Immune Reaction: Immune-complex Hypersensitivity
Immune Reaction: Cellular (Delayed) Hypersensitivity
Hypersensitivity Disease
Allergic Disease
Autoimmune Disease
Immunity in Organ and Tissue Transplantation
Immunity in Blood Transfusion
Amyloidosis
Immunodeficiency Diseases
Inherited Immunodeficiency Diseases
Acquired Immunodeficiency Syndrome (AIDS)
Malignancies of Immune Cells
Infectious Disease
Back to Basics
Infection
Contagion
The Spread of Organisms in Tissue
Mechanisms of Microbiologic Injury
The Inflammatory Response to Infection
Infections of Organ Systems
Respiratory Infections
Gastrointestinal Infections
Genitourinary Infections
Skin Infections
Infections by Pyogenic Bacteria
Infections by Clostridium Organisms and Other Necrotizing Agents
Opportunistic and AIDS-related Infections
Tropical, Vector-borne, and Parasite Infections
Vector-borne Infections
Parasitic Infections
The Natural Course of an Infection
Signs and Symptoms of Infection
Laboratory Tools
Disorders of Daily Life and Diet
Injury Resulting from Trauma
Injury Resulting from Extremes of Temperature
Thermal Burns
Cold Injury
Heat Cramps, Heat Exhaustion, and Heat Stroke
Pollution and Occupational Disease
Exposure to Toxic Materials
Chemicals
Adverse Reactions to Therapeutic Drugs
Radiation
Inhalant Lung Disease
Tobacco, Alcohol, and Drugs
Cigarette Smoking
Alcohol Abuse
Drug Abuse
Nutritional Disease
Malnutrition
Obesity
The Metabolic Syndrome
Diseases of Organ Systems
Diseases of Blood Cells and Blood Coagulation
Diseases of Blood Cells
Back to Basics
Normal Blood Production (Hematopoiesis)
Cell Compartments and Life Span
Laboratory Assessment of Blood Cells
Too Little Hemoglobin (Anemia)
The Anemia of Hemorrhage
Anemia of Red Cell Destruction (Hemolytic Anemias)
Anemia of Insufficient Red Cell Production
Too Many Red Cells-Polycythemia
Too Few White Cells-Leukopenia and Agranulocytosis
Too Many White Cells-Benign and Malignant Disorders of Leukocytes
Peripheral Leukocyte Responses to Infection or Injury
Lymph Node Response to Injury or Infection
Lymphoid Neoplasms
Myeloid Neoplasms
Disorders of the Spleen and Thymus
Bleeding Disorders
Back to Basics
Bleeding Disorders
Vascular or Platelet Deficiency
Coagulation Factor Deficiency
Disseminated Intravascular Coagulation (DIC)
Thrombotic Disorders
Diseases of Blood Vessels
Back to Basics
The Normal Vascular System
Regulation of Blood Pressure
Lipid Classification and Metabolism
Desirable Plasma Lipid Concentrations
Nomenclature of Blood Vessel Disease
Atherosclerosis
The Causes and Consequences of Atherosclerosis
The Pathogenesis of Atherosclerosis
Risk Factors for Atherosclerosis
The Pathologic Anatomy of Atherosclerosis
Clinical Manifestations of Atherosclerosis
Hypertension
Types of Hypertension
Pathogenesis of Hypertension
The Pathology of Hypertension
Clinical Aspects of Hypertension
Aneurysms and Dissections
Vasculitis
Raynaud Phenomenon
Diseases of Veins
Tumors of Blood and Lymphatic Vessels
Diseases of the Heart
Back to Basics
The Normal Heart
The Coronary Circulation
The Cardiac Cycle
Arrhythmias
Congestive Heart Failure
Pathophysiology
Etiology
Clinical Features
Ischemic Heart Disease (Coronary Artery Disease)
Epidemiology of Ischemic Heart Disease
Causes of Coronary Ischemia
Angina Pectoris
Myocardial Infarction
Chronic Myocardial Ischemia
Sudden Cardiac Death
Hypertensive Heart Disease
Valvular Heart Disease
Rheumatic Heart Disease
Calcific Aortic Stenosis
Myxomatous Degeneration of the Mitral Valve
Endocarditis
Nonbacterial Thrombotic Endocarditis
Infective Endocarditis
Primary Myocardial Diseases
Myocarditis
Cardiomyopathies
Congenital Heart Disease
Malformations With Shunts
Malformations With Obstruction to Flow
Pericardial Disease
Diseases of the Respiratory System
Back to Basics
The Normal Respiratory Tract
Lung Volume, Air Flow, and Gas Exchange
Diseases of the Upper Respiratory Tract
Atelectasis (Collapse)
Obstructive Lung Disease
Asthma
Chronic Obstructive Pulmonary Disease (COPD)
Restrictive Lung Disease
Interstitial Fibrosis without Granulomatous Inflammation
Interstitial Fibrosis with Granulomatous Inflammation
Vascular and Circulatory Lung Disease
Pulmonary Edema
Pulmonary Thromboembolism
Pulmonary Hypertension
Adult Respiratory Distress Syndrome
Pulmonary Infections
Pneumonia
Lung Abscess
Pulmonary Tuberculosis
Pulmonary Fungus Infections (Deep Mycoses)
Other Lung Infections
Lung Neoplasms
Bronchogenic Carcinoma
Bronchial Carcinoid Tumor
Diseases of the Pleura
Diseases of the Gastrointestinal Tract
Back to Basics
The Mouth and Esophagus
The Stomach
The Small Intestine
The Large Bowel
Intestinal Bacteria
Intestinal Bleeding
Intestinal Obstruction and Ileus
Diseases of the Oral Cavity
Diseases of Salivary Glands
Diseases of the Esophagus
Diseases of the Stomach
Gastritis
Gastric and Duodenal Ulcers
Carcinoma of the Stomach
Nonneoplastic Diseases of the Small Bowel and Large Bowel
Congenital Anomalies
Vascular Diseases
Diarrheal Diseases
Malabsorption Syndromes
Inflammatory Bowel Disease
Colonic Diverticulosis and Other Conditions
Peritonitis
Neoplasms of the Large and Small Bowel
Nonneoplastic Polyps
Neoplastic Polyps (Adenomas)
Carcinoma of the Colon
Diseases of the Appendix
Diseases of the Liver and Biliary Tract
Back to Basics
Liver Anatomy
Liver Function
The Liver Response to Injury
Anatomic Patterns of Liver Injury
Functional Patterns of Liver Injury
Cirrhosis
Anatomic Types of Cirrhosis
The Pathophysiology of Cirrhosis
Clinical Features of Cirrhosis
Viral Hepatitis
Clinicopathologic Syndromes
Hepatitis A Virus (HAV) Infection
Hepatitis B Virus (HBV) Infection
Hepatitis C Virus (HCV) Infection
Hepatitis D Virus (HDV) Infection
Hepatitis E virus (HEV) Infection
The Anatomic Pathology of Hepatitis
Autoimmune Hepatitis
Liver Abscess
Toxic Liver Injury
Alcoholic Liver Disease
Fatty Liver
Alcoholic Hepatitis
Alcoholic Cirrhosis
Inherited Metabolic and Pediatric Liver Disease
Hemochromatosis
Wilson Disease
Hereditary Alpha-1 Antitrypsin Deficiency
Neonatal Cholestasis, Biliary Atresia, and Hepatitis
Reye syndrome
Disease of Intrahepatic Bile Ducts
Primary Biliary Cirrhosis
Primary Sclerosing Cholangitis
Circulatory Disorders
Tumors of the Liver
Primary Carcinomas of the Liver
Cholangiocarcinoma
Diseases of the Gallbladder and Extrahepatic Bile Ducts
Diseases of the Gallbladder
Diseases of Extrahepatic Bile Ducts
Diseases of the Pancreas
Back to Basics
The Digestive (Exocrine) Pancreas
The Hormonal (Endocrine) Pancreas
Diseases of the Digestive (Exocrine) Pancreas
Pancreatitis
Carcinoma of the Pancreas
Diseases of the Hormonal (Endocrine) Pancreas
Diabetes Mellitus
Pancreatic Endocrine Neoplasms
Diseases of Endocrine Glands
Back to Basics
Homeostasis
The Pituitary Gland
The Thyroid Gland
The Parathyroid Glands
The Adrenal Glands
Diseases of the Pituitary Gland
Diseases Affecting the Anterior Pituitary
Disease of the Posterior Pituitary
Diseases of the Thyroid Gland
Overactivity of the Thyroid Gland (Hyperthyroidism)
Underactivity of the Thyroid Gland (Hypothyroidism)
Goiter
Thyroiditis
Neoplasms of the Thyroid Gland
Diseases of the Parathyroid Glands
Overactivity of the Parathyroid Glands (Hyperparathyroidism)
Underactivity of the Parathyroid Glands (Hypoparathyroidism)
Diseases of the Adrenal Gland
Diseases of the Adrenal Cortex
Diseases of the Adrenal Medulla
Diseases of the Kidney
Back to Basics
Renal Function
The Normal Glomerulus
Formation of the Glomerular Filtrate
Tubular Processing of the Glomerular Filtrate
The Language of Renal Disease
Normal Urine and Urinalysis
Clinical Syndromes of Renal Disease
Inherited, Congenital, and Developmental Disease
Glomerular Disease
The Initiation and Progression of Glomerular Disease
Glomerulonephritis
Secondary Glomerular Disease
Diseases of Renal Vasculature
Acute Tubular Necrosis
Tubulointerstitial Nephritis
Obstruction, Reflux, and Stasis
Pyelonephritis and Urinary Tract Infection
Drugs, Toxins, and Other Causes of Tubulointerstitial Nephritis
Renal Stones
Tumors of the Kidney
Diseases of the Lower Urinary Tract and Male Genitalia
Back to Basics
Diseases of the Lower Urinary Tract
Congenital Anomalies
Urinary Obstruction, Reflux, and Stasis
Infection and Inflammation
Neoplasms
Diseases of the Male Genitalia
Erectile Dysfunction and Infertility
Diseases of the Penis and Urethra
Diseases of the Scrotum and Groin
Diseases of the Testis and Epididymis
Diseases of the Prostate
Sexually Transmitted Disease
Syphilis
Gonorrhea
Nongonococcal Urethritis
Genital Herpes and Other Sexually Transmitted Diseases
Diseases of the Female Genital Tract and Breast
Diseases of the Female Genital Tract
Back to Basics
The Pituitary-Ovarian Cycle
Ovulation
The Menstrual Cycle
Menopause
Sexually Transmitted Disease
Vaginitis and Other Vaginal Conditions
Vulvar Disease
Diseases of the Cervix
Ectropion, Polyps, and Cervicitis
Dysplasia and Carcinoma of the Cervix
Diseases of the Endometrium and Myometrium
Abnormal Endometrial Bleeding
Endometriosis
Endometrial Polyps, Hyperplasia, and Adenocarcinoma
Other Conditions of the Uterus and Pelvis
Diseases of the Fallopian Tube
Diseases of the Ovary
Nonneoplastic Ovarian Cysts
Tumors of the Ovary
Diseases of Reproduction
Infertility
Ectopic Pregnancy and Abortion
Placental Disease
Diseases of the Breast
Back to Basics
Inflammatory Disease
Fibrocystic Change
Benign Tumors
Breast Cancer
Types of Breast Cancer
Factors Affecting the Risk of Developing Breast Cancer
Prognostic Factors for Patients with Breast Cancer
Clinical Presentation and Behavior
Diagnosis and Treatment
Diseases of the Male Breast
Diseases of Bones, Joints, and Skeletal Muscle
Diseases of Bone
Back to Basics
Skeletal Deformities and Disorders of Bone Growth
Fractures
Bone Infection
Bone Infarct
Osteoporosis
Osteomalacia
Bone Tumors
Bone-forming Tumors
Cartilage-forming Tumors
Fibrous Tumors and Tumor-like Conditions
Other Tumors of Bone
Diseases of Joints and Related Tissues
Back to Basics
Osteoarthritis
Rheumatoid Arthritis
Spondyloarthropathies
Other Types of Arthritis
Injuries to Ligaments, Tendons, and Joints
Periarticular Pain Syndromes
Tumors and Tumor-like Lesions of Joints
Diseases of Skeletal Muscle
Back to Basics
Muscle Atrophy
Muscular Dystrophy
Myositis and Myopathy
Myasthenia Gravis
Tumors and Tumor-like Lesions of Soft Tissue
Diseases of the Nervous System
Back to Basics
The Central Nervous System
Vascular Supply
The Peripheral Nervous System
The Autonomic Nervous System
Cells of the Nervous System
Nerve Cell Connections and Signals
Congenital and Perinatal Disease
Increased Intracranial Pressure
Intracranial Hemorrhage
Bleeding on the Surface of the Brain
Bleeding Directly Into the Brain
Ischemia and Infarction
Brain and Spinal Cord Trauma
Infections of the Central Nervous System
Infections of the Meninges and Cerebrospinal Fluid
Infections of Brain Parenchyma
Degenerative Diseases
Degenerative Diseases of Gray Matter
Degenerative Diseases of White Matter
Metabolic and Toxic Disorders
Neoplasms
Diseases of Peripheral Nerves
Neuropathies
Neoplasms
Diseases of the Skin
Back to Basics
Nonneoplastic Diseases of Skin
The Uniqueness of Skin Disease
General Conditions of Skin
The Effects of Sunlight
The Effects of Pregnancy
Disorders of Hair Growth
The Skin in Systemic Disease
Diseases of the Epidermis
Disorders of Pigmentation
Other Diseases of the Epidermis
Diseases of the Basement Membrane Zone
Diseases of the Dermis
Noncontact Dermatitis
Contact Dermatitis
Inflammatory Diseases of Subcuticular Fat
Acne
Infections and Infestations
Neoplasms of Skin
Tumors of the Epidermis
Keratoses
Malignant Tumors of the Epidermis
Tumors of Subepidermal Tissue
Tumors of Melanocytes
Nevi
Malignant Melanoma
Diseases of the Eye and Ear
Diseases of the Eye
Back to Basics
The Anterior Segment
The Posterior Segment
Disorders of Alignment and Movement
Disorders of Refraction
Disorders of the Orbit
Disorders of the Eyelid, Conjunctiva, Sclera, and Lacrimal Apparatus
Disorders of the Cornea
Cataract
Disorders of the Uveal Tract
Disorders of the Retina and Vitreous Humor
Disorders of the Optic Nerve
Glaucoma
Neoplasms
Diseases of the Ear
Back to Basics
Disorders of the External Ear
Disorders of the Middle Ear
Disorders of the Inner Ear
Deafness
Glossary
Index of Case Studies
Index

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