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Dedication | |
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Preface | |
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Additional Learning Resources | |
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User's Guide | |
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Acknowledgments | |
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Reviewers | |
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Guide to Case Studies | |
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General Pathology | |
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The Nature of Disease: How to Think about Illness | |
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The Nature of Disease | |
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Bodily Structure and Function in Disease | |
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Healthy Is Not the Same as Normal; Sick Is Not the Same as Abnormal | |
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Defining Normal | |
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The Extent of Abnormality | |
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Test Sensitivity and Specificity | |
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The Usefulness of Tests in Diagnosis | |
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The Effect of Disease Prevalence on Test Usefulness | |
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Initial Tests and Follow-up Tests | |
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Disease and Diagnosis | |
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Cell Injury, Adaptation, and Death | |
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Back to Basics | |
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The Origins of Cells and the Organization of Tissues | |
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The Nucleus | |
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The Cytoplasm | |
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The Cell Membrane | |
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The Cell Cycle | |
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Cellular Communication | |
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Biologic Aging | |
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Cell Injury and Disease | |
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Mild Cell Injury | |
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Intracellular Accumulations | |
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Adaptations of Cell Growth and Differentiation | |
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Severe Cell Injury and Cell Death | |
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Inflammation: The Reaction to Injury | |
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The Inflammatory Response to Injury | |
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The Cellular Response in Inflammation | |
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The Vascular Response in Inflammation | |
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Molecular Mediators of Inflammation | |
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Acute Inflammation | |
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The Pathogenesis of Acute Inflammation | |
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The Anatomic Characteristics of Acute Inflammation | |
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The Consequences of Acute Inflammation | |
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Chronic Inflammation | |
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The Pathogenesis of Chronic Inflammation | |
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The Anatomic Characteristics of Chronic Inflammation | |
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The Consequences of Chronic Inflammation | |
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Distant Effects of Inflammation | |
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Lymphangitis, Lymphadenitis, and Lymphadenopathy | |
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Systemic Effects of Inflammation | |
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The Inflammatory Response to Infection | |
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Repair: Recovery from Injury | |
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Definitions | |
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Replacement of Injured Cells | |
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The Importance of Tissue Structure | |
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The Control of Cell Reproduction and Tissue Growth | |
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Wound Healing and Fibrous Repair | |
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Cell Migration into the Wound | |
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The Growth of New Blood Vessels | |
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Scar Development | |
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Healing by First Intention | |
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Healing by Second Intention | |
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Abnormal Wound Healing | |
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Host Factors Interfering with Wound Healing | |
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Pathologic Wound Healing | |
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Overview of Injury, Inflammation, and Repair | |
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Disorders of Fluid Balance and Blood Flow | |
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Back to Basics | |
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Blood Pressure | |
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Osmotic Pressure | |
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The Circulation of Blood and Lymph | |
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The Anatomy of Blood Vessels and Lymphatics | |
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Body Water and Fluid Compartments | |
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Edema | |
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Low-protein Edema | |
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High-protein Edema | |
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Clinical Aspects of Edema | |
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Hyperemia and Congestion | |
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Hemorrhage, Thrombosis, and Embolism | |
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Hemorrhage | |
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Thrombosis | |
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Embolism | |
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Blood Flow Obstruction | |
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Infarction | |
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The Development of an Infarct | |
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The Collapse of Circulation: Shock | |
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Types of Shock | |
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Stages of Shock | |
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Neoplasms | |
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The Language of Neoplasia | |
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Types of Neoplasms | |
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The Molecular and Genetic Basis of Neoplasia | |
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Mutations | |
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Cell Growth Control Genes | |
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DNA Repair | |
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The Causes of Cancer | |
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The Structure of Neoplasms | |
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The Gross Anatomy of Neoplasms | |
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The Microscopic Anatomy of Neoplasms | |
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Premalignant States and Conditions | |
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The Biology of Neoplastic Growth | |
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The Differentiation of Tumor Cells | |
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Clones of Cells | |
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The Speed of Tumor Growth | |
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The Nourishment of Tumors | |
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Tumor Cell Variation | |
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The Spread of Neoplasms | |
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The Immune Defense Against Neoplasia | |
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The Epidemiology of Cancer | |
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The Clinical Picture of Cancer | |
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Clinical and Laboratory Assessment of Neoplasms | |
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Clinical History | |
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Obtaining Tissues and Cells for Diagnosis | |
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Grading and Staging of Malignancies | |
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Early Detection of Cancer | |
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Tumor Markers | |
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Developmental Genetic, and Pediatric Disease | |
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Developmental Abnormalities | |
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Embryologic Development | |
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Congenital Malformations | |
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Congenital Deformations | |
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Genetic Disorders | |
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Mutations | |
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The Broad Influence of Genetics in Disease | |
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Disease of Single Genes (Monogenic Disorders) | |
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Disease Caused by Defective Dominant Autosomal Genes | |
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Disease Caused by Defective Recessive Autosomal Genes | |
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Disease Caused by Defective Genes on Sex Chromosomes | |
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Clinical Expression of Single-Gene Defects | |
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Cytogenetic Diseases | |
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Disease Associated with Abnormal Numbers of Autosomes | |
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Disease Associated with Abnormal Numbers of Sex Chromosomes | |
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Genetic Diagnosis | |
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Pediatric Diseases | |
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Perinatal and Neonatal Disease | |
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Intrauterine Growth Restriction | |
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Prematurity | |
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Birth Injury | |
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Fetal and Newborn Infections | |
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Infections in Children | |
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Sudden Infant Death Syndrome (SIDS) | |
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Hemolytic Disease of the Newborn (Erythroblastosis Fetalis) | |
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Cystic Fibrosis | |
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Tumors and Tumor-like Conditions of Children | |
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Diseases of the Immune System | |
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Back to Basics | |
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Nonimmune Defense Mechanisms | |
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The Normal Immune System | |
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Immunity in Blood Transfusion | |
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Classification of Immune Disease | |
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Mechanisms of Immune Reaction | |
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Immune Reaction: Immediate Hypersensitivity | |
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Immune Reaction: Cytotoxic Hypersensitivity | |
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Immune Reaction: Immune-complex Hypersensitivity | |
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Immune Reaction: Cellular (Delayed) Hypersensitivity | |
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Hypersensitivity Disease | |
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Allergic Disease | |
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Autoimmune Disease | |
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Immunity in Organ and Tissue Transplantation | |
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Immunity in Blood Transfusion | |
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Amyloidosis | |
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Immunodeficiency Diseases | |
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Inherited Immunodeficiency Diseases | |
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Acquired Immunodeficiency Syndrome (AIDS) | |
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Malignancies of Immune Cells | |
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Infectious Disease | |
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Back to Basics | |
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Infection | |
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Contagion | |
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The Spread of Organisms in Tissue | |
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Mechanisms of Microbiologic Injury | |
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The Inflammatory Response to Infection | |
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Infections of Organ Systems | |
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Respiratory Infections | |
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Gastrointestinal Infections | |
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Genitourinary Infections | |
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Skin Infections | |
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Infections by Pyogenic Bacteria | |
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Infections by Clostridium Organisms and Other Necrotizing Agents | |
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Opportunistic and AIDS-related Infections | |
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Tropical, Vector-borne, and Parasite Infections | |
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Vector-borne Infections | |
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Parasitic Infections | |
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The Natural Course of an Infection | |
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Signs and Symptoms of Infection | |
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Laboratory Tools | |
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Disorders of Daily Life and Diet | |
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Injury Resulting from Trauma | |
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Injury Resulting from Extremes of Temperature | |
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Thermal Burns | |
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Cold Injury | |
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Heat Cramps, Heat Exhaustion, and Heat Stroke | |
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Pollution and Occupational Disease | |
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Exposure to Toxic Materials | |
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Chemicals | |
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Adverse Reactions to Therapeutic Drugs | |
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Radiation | |
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Inhalant Lung Disease | |
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Tobacco, Alcohol, and Drugs | |
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Cigarette Smoking | |
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Alcohol Abuse | |
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Drug Abuse | |
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Nutritional Disease | |
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Malnutrition | |
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Obesity | |
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The Metabolic Syndrome | |
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Diseases of Organ Systems | |
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Diseases of Blood Cells and Blood Coagulation | |
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Diseases of Blood Cells | |
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Back to Basics | |
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Normal Blood Production (Hematopoiesis) | |
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Cell Compartments and Life Span | |
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Laboratory Assessment of Blood Cells | |
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Too Little Hemoglobin (Anemia) | |
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The Anemia of Hemorrhage | |
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Anemia of Red Cell Destruction (Hemolytic Anemias) | |
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Anemia of Insufficient Red Cell Production | |
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Too Many Red Cells-Polycythemia | |
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Too Few White Cells-Leukopenia and Agranulocytosis | |
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Too Many White Cells-Benign and Malignant Disorders of Leukocytes | |
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Peripheral Leukocyte Responses to Infection or Injury | |
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Lymph Node Response to Injury or Infection | |
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Lymphoid Neoplasms | |
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Myeloid Neoplasms | |
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Disorders of the Spleen and Thymus | |
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Bleeding Disorders | |
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Back to Basics | |
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Bleeding Disorders | |
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Vascular or Platelet Deficiency | |
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Coagulation Factor Deficiency | |
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Disseminated Intravascular Coagulation (DIC) | |
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Thrombotic Disorders | |
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Diseases of Blood Vessels | |
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Back to Basics | |
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The Normal Vascular System | |
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Regulation of Blood Pressure | |
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Lipid Classification and Metabolism | |
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Desirable Plasma Lipid Concentrations | |
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Nomenclature of Blood Vessel Disease | |
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Atherosclerosis | |
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The Causes and Consequences of Atherosclerosis | |
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The Pathogenesis of Atherosclerosis | |
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Risk Factors for Atherosclerosis | |
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The Pathologic Anatomy of Atherosclerosis | |
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Clinical Manifestations of Atherosclerosis | |
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Hypertension | |
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Types of Hypertension | |
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Pathogenesis of Hypertension | |
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The Pathology of Hypertension | |
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Clinical Aspects of Hypertension | |
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Aneurysms and Dissections | |
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Vasculitis | |
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Raynaud Phenomenon | |
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Diseases of Veins | |
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Tumors of Blood and Lymphatic Vessels | |
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Diseases of the Heart | |
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Back to Basics | |
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The Normal Heart | |
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The Coronary Circulation | |
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The Cardiac Cycle | |
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Arrhythmias | |
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Congestive Heart Failure | |
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Pathophysiology | |
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Etiology | |
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Clinical Features | |
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Ischemic Heart Disease (Coronary Artery Disease) | |
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Epidemiology of Ischemic Heart Disease | |
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Causes of Coronary Ischemia | |
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Angina Pectoris | |
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Myocardial Infarction | |
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Chronic Myocardial Ischemia | |
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Sudden Cardiac Death | |
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Hypertensive Heart Disease | |
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Valvular Heart Disease | |
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Rheumatic Heart Disease | |
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Calcific Aortic Stenosis | |
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Myxomatous Degeneration of the Mitral Valve | |
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Endocarditis | |
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Nonbacterial Thrombotic Endocarditis | |
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Infective Endocarditis | |
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Primary Myocardial Diseases | |
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Myocarditis | |
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Cardiomyopathies | |
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Congenital Heart Disease | |
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Malformations With Shunts | |
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Malformations With Obstruction to Flow | |
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Pericardial Disease | |
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Diseases of the Respiratory System | |
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Back to Basics | |
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The Normal Respiratory Tract | |
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Lung Volume, Air Flow, and Gas Exchange | |
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Diseases of the Upper Respiratory Tract | |
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Atelectasis (Collapse) | |
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Obstructive Lung Disease | |
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Asthma | |
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Chronic Obstructive Pulmonary Disease (COPD) | |
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Restrictive Lung Disease | |
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Interstitial Fibrosis without Granulomatous Inflammation | |
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Interstitial Fibrosis with Granulomatous Inflammation | |
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Vascular and Circulatory Lung Disease | |
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Pulmonary Edema | |
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Pulmonary Thromboembolism | |
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Pulmonary Hypertension | |
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Adult Respiratory Distress Syndrome | |
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Pulmonary Infections | |
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Pneumonia | |
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Lung Abscess | |
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Pulmonary Tuberculosis | |
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Pulmonary Fungus Infections (Deep Mycoses) | |
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Other Lung Infections | |
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Lung Neoplasms | |
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Bronchogenic Carcinoma | |
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Bronchial Carcinoid Tumor | |
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Diseases of the Pleura | |
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Diseases of the Gastrointestinal Tract | |
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Back to Basics | |
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The Mouth and Esophagus | |
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The Stomach | |
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The Small Intestine | |
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The Large Bowel | |
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Intestinal Bacteria | |
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Intestinal Bleeding | |
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Intestinal Obstruction and Ileus | |
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Diseases of the Oral Cavity | |
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Diseases of Salivary Glands | |
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Diseases of the Esophagus | |
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Diseases of the Stomach | |
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Gastritis | |
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Gastric and Duodenal Ulcers | |
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Carcinoma of the Stomach | |
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Nonneoplastic Diseases of the Small Bowel and Large Bowel | |
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Congenital Anomalies | |
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Vascular Diseases | |
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Diarrheal Diseases | |
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Malabsorption Syndromes | |
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Inflammatory Bowel Disease | |
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Colonic Diverticulosis and Other Conditions | |
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Peritonitis | |
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Neoplasms of the Large and Small Bowel | |
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Nonneoplastic Polyps | |
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Neoplastic Polyps (Adenomas) | |
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Carcinoma of the Colon | |
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Diseases of the Appendix | |
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Diseases of the Liver and Biliary Tract | |
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Back to Basics | |
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Liver Anatomy | |
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Liver Function | |
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The Liver Response to Injury | |
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Anatomic Patterns of Liver Injury | |
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Functional Patterns of Liver Injury | |
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Cirrhosis | |
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Anatomic Types of Cirrhosis | |
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The Pathophysiology of Cirrhosis | |
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Clinical Features of Cirrhosis | |
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Viral Hepatitis | |
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Clinicopathologic Syndromes | |
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Hepatitis A Virus (HAV) Infection | |
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Hepatitis B Virus (HBV) Infection | |
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Hepatitis C Virus (HCV) Infection | |
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Hepatitis D Virus (HDV) Infection | |
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Hepatitis E virus (HEV) Infection | |
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The Anatomic Pathology of Hepatitis | |
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Autoimmune Hepatitis | |
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Liver Abscess | |
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Toxic Liver Injury | |
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Alcoholic Liver Disease | |
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Fatty Liver | |
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Alcoholic Hepatitis | |
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Alcoholic Cirrhosis | |
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Inherited Metabolic and Pediatric Liver Disease | |
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Hemochromatosis | |
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Wilson Disease | |
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Hereditary Alpha-1 Antitrypsin Deficiency | |
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Neonatal Cholestasis, Biliary Atresia, and Hepatitis | |
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Reye syndrome | |
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Disease of Intrahepatic Bile Ducts | |
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Primary Biliary Cirrhosis | |
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Primary Sclerosing Cholangitis | |
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Circulatory Disorders | |
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Tumors of the Liver | |
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Primary Carcinomas of the Liver | |
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Cholangiocarcinoma | |
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Diseases of the Gallbladder and Extrahepatic Bile Ducts | |
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Diseases of the Gallbladder | |
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Diseases of Extrahepatic Bile Ducts | |
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Diseases of the Pancreas | |
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Back to Basics | |
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The Digestive (Exocrine) Pancreas | |
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The Hormonal (Endocrine) Pancreas | |
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Diseases of the Digestive (Exocrine) Pancreas | |
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Pancreatitis | |
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Carcinoma of the Pancreas | |
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Diseases of the Hormonal (Endocrine) Pancreas | |
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Diabetes Mellitus | |
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Pancreatic Endocrine Neoplasms | |
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Diseases of Endocrine Glands | |
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Back to Basics | |
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Homeostasis | |
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The Pituitary Gland | |
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The Thyroid Gland | |
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The Parathyroid Glands | |
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The Adrenal Glands | |
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Diseases of the Pituitary Gland | |
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Diseases Affecting the Anterior Pituitary | |
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Disease of the Posterior Pituitary | |
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Diseases of the Thyroid Gland | |
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Overactivity of the Thyroid Gland (Hyperthyroidism) | |
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Underactivity of the Thyroid Gland (Hypothyroidism) | |
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Goiter | |
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Thyroiditis | |
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Neoplasms of the Thyroid Gland | |
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Diseases of the Parathyroid Glands | |
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Overactivity of the Parathyroid Glands (Hyperparathyroidism) | |
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Underactivity of the Parathyroid Glands (Hypoparathyroidism) | |
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Diseases of the Adrenal Gland | |
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Diseases of the Adrenal Cortex | |
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Diseases of the Adrenal Medulla | |
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Diseases of the Kidney | |
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Back to Basics | |
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Renal Function | |
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The Normal Glomerulus | |
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Formation of the Glomerular Filtrate | |
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Tubular Processing of the Glomerular Filtrate | |
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The Language of Renal Disease | |
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Normal Urine and Urinalysis | |
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Clinical Syndromes of Renal Disease | |
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Inherited, Congenital, and Developmental Disease | |
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Glomerular Disease | |
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The Initiation and Progression of Glomerular Disease | |
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Glomerulonephritis | |
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Secondary Glomerular Disease | |
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Diseases of Renal Vasculature | |
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Acute Tubular Necrosis | |
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Tubulointerstitial Nephritis | |
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Obstruction, Reflux, and Stasis | |
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Pyelonephritis and Urinary Tract Infection | |
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Drugs, Toxins, and Other Causes of Tubulointerstitial Nephritis | |
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Renal Stones | |
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Tumors of the Kidney | |
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Diseases of the Lower Urinary Tract and Male Genitalia | |
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Back to Basics | |
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Diseases of the Lower Urinary Tract | |
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Congenital Anomalies | |
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Urinary Obstruction, Reflux, and Stasis | |
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Infection and Inflammation | |
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Neoplasms | |
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Diseases of the Male Genitalia | |
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Erectile Dysfunction and Infertility | |
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Diseases of the Penis and Urethra | |
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Diseases of the Scrotum and Groin | |
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Diseases of the Testis and Epididymis | |
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Diseases of the Prostate | |
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Sexually Transmitted Disease | |
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Syphilis | |
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Gonorrhea | |
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Nongonococcal Urethritis | |
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Genital Herpes and Other Sexually Transmitted Diseases | |
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Diseases of the Female Genital Tract and Breast | |
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Diseases of the Female Genital Tract | |
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Back to Basics | |
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The Pituitary-Ovarian Cycle | |
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Ovulation | |
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The Menstrual Cycle | |
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Menopause | |
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Sexually Transmitted Disease | |
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Vaginitis and Other Vaginal Conditions | |
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Vulvar Disease | |
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Diseases of the Cervix | |
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Ectropion, Polyps, and Cervicitis | |
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Dysplasia and Carcinoma of the Cervix | |
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Diseases of the Endometrium and Myometrium | |
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Abnormal Endometrial Bleeding | |
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Endometriosis | |
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Endometrial Polyps, Hyperplasia, and Adenocarcinoma | |
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Other Conditions of the Uterus and Pelvis | |
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Diseases of the Fallopian Tube | |
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Diseases of the Ovary | |
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Nonneoplastic Ovarian Cysts | |
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Tumors of the Ovary | |
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Diseases of Reproduction | |
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Infertility | |
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Ectopic Pregnancy and Abortion | |
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Placental Disease | |
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Diseases of the Breast | |
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Back to Basics | |
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Inflammatory Disease | |
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Fibrocystic Change | |
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Benign Tumors | |
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Breast Cancer | |
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Types of Breast Cancer | |
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Factors Affecting the Risk of Developing Breast Cancer | |
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Prognostic Factors for Patients with Breast Cancer | |
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Clinical Presentation and Behavior | |
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Diagnosis and Treatment | |
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Diseases of the Male Breast | |
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Diseases of Bones, Joints, and Skeletal Muscle | |
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Diseases of Bone | |
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| |
Back to Basics | |
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| |
Skeletal Deformities and Disorders of Bone Growth | |
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Fractures | |
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Bone Infection | |
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Bone Infarct | |
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Osteoporosis | |
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Osteomalacia | |
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Bone Tumors | |
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Bone-forming Tumors | |
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Cartilage-forming Tumors | |
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Fibrous Tumors and Tumor-like Conditions | |
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Other Tumors of Bone | |
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Diseases of Joints and Related Tissues | |
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Back to Basics | |
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Osteoarthritis | |
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Rheumatoid Arthritis | |
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Spondyloarthropathies | |
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Other Types of Arthritis | |
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Injuries to Ligaments, Tendons, and Joints | |
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Periarticular Pain Syndromes | |
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Tumors and Tumor-like Lesions of Joints | |
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Diseases of Skeletal Muscle | |
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Back to Basics | |
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Muscle Atrophy | |
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Muscular Dystrophy | |
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Myositis and Myopathy | |
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Myasthenia Gravis | |
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Tumors and Tumor-like Lesions of Soft Tissue | |
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Diseases of the Nervous System | |
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Back to Basics | |
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The Central Nervous System | |
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Vascular Supply | |
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The Peripheral Nervous System | |
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The Autonomic Nervous System | |
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Cells of the Nervous System | |
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Nerve Cell Connections and Signals | |
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Congenital and Perinatal Disease | |
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Increased Intracranial Pressure | |
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Intracranial Hemorrhage | |
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Bleeding on the Surface of the Brain | |
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Bleeding Directly Into the Brain | |
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Ischemia and Infarction | |
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Brain and Spinal Cord Trauma | |
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Infections of the Central Nervous System | |
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Infections of the Meninges and Cerebrospinal Fluid | |
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Infections of Brain Parenchyma | |
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Degenerative Diseases | |
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Degenerative Diseases of Gray Matter | |
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Degenerative Diseases of White Matter | |
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Metabolic and Toxic Disorders | |
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Neoplasms | |
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Diseases of Peripheral Nerves | |
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Neuropathies | |
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Neoplasms | |
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Diseases of the Skin | |
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| |
Back to Basics | |
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Nonneoplastic Diseases of Skin | |
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| |
The Uniqueness of Skin Disease | |
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| |
General Conditions of Skin | |
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The Effects of Sunlight | |
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| |
The Effects of Pregnancy | |
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| |
Disorders of Hair Growth | |
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The Skin in Systemic Disease | |
| |
| |
Diseases of the Epidermis | |
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| |
Disorders of Pigmentation | |
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Other Diseases of the Epidermis | |
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Diseases of the Basement Membrane Zone | |
| |
| |
Diseases of the Dermis | |
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| |
Noncontact Dermatitis | |
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Contact Dermatitis | |
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Inflammatory Diseases of Subcuticular Fat | |
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Acne | |
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| |
Infections and Infestations | |
| |
| |
| |
Neoplasms of Skin | |
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Tumors of the Epidermis | |
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| |
Keratoses | |
| |
| |
Malignant Tumors of the Epidermis | |
| |
| |
Tumors of Subepidermal Tissue | |
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| |
Tumors of Melanocytes | |
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| |
Nevi | |
| |
| |
Malignant Melanoma | |
| |
| |
| |
Diseases of the Eye and Ear | |
| |
| |
| |
Diseases of the Eye | |
| |
| |
Back to Basics | |
| |
| |
The Anterior Segment | |
| |
| |
The Posterior Segment | |
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| |
Disorders of Alignment and Movement | |
| |
| |
Disorders of Refraction | |
| |
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Disorders of the Orbit | |
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Disorders of the Eyelid, Conjunctiva, Sclera, and Lacrimal Apparatus | |
| |
| |
Disorders of the Cornea | |
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| |
Cataract | |
| |
| |
Disorders of the Uveal Tract | |
| |
| |
Disorders of the Retina and Vitreous Humor | |
| |
| |
Disorders of the Optic Nerve | |
| |
| |
Glaucoma | |
| |
| |
Neoplasms | |
| |
| |
| |
Diseases of the Ear | |
| |
| |
Back to Basics | |
| |
| |
Disorders of the External Ear | |
| |
| |
Disorders of the Middle Ear | |
| |
| |
Disorders of the Inner Ear | |
| |
| |
Deafness | |
| |
| |
Glossary | |
| |
| |
Index of Case Studies | |
| |
| |
Index | |