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Preface | |
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Acknowledgments | |
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About the Authors | |
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Introduction | |
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The History and Scope of Epidemiology | |
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Introduction | |
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Epidemiology Defined | |
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Foundations of Epidemiology | |
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Historical Antecedents of Epidemiology | |
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Recent Applications of Epidemiology | |
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Conclusion | |
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Study Questions and Exercises | |
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Practical Applications of Epidemiology | |
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Introduction | |
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Applications for the Assessment of the Health Status of Populations and Delivery of Health Services | |
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Applications Relevant to Disease Etiology | |
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Conclusion | |
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Study Questions and Exercises | |
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Data for Study Question 9 | |
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Measures of Morbidity and Mortality Used in Epidemiology | |
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Introduction | |
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Definitions of Count, Proportion, Ratio, and Rate | |
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Risk Versus Rate | |
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Interrelationship Between Prevalence and Incidence | |
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Applications of Incidence Data | |
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Crude Rates | |
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Specific Rates | |
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Adjusted Rates | |
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Conclusion | |
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Study Questions and Exercises | |
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Data for Study Questions 2 Through 5 | |
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Descriptive Epidemiology: Person, Place, Time | |
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Introduction | |
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Characteristics of Persons | |
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Characteristics of Place | |
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Characteristics of Time | |
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Conclusion | |
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Study Questions and Exercises | |
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Project: Descriptive Epidemiology of a Selected Health Problem | |
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Sources of Data for Use in Epidemiology | |
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Introduction | |
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Criteria for the Quality and Utility of Epidemiologic Data | |
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Computerized Bibliographic Databases | |
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Confidentiality, Sharing of Data, and Record Linkage | |
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Statistics Derived from the Vital Registration System | |
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Reportable Disease Statistics | |
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Screening Surveys | |
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Disease Registries | |
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Morbidity Surveys of the General Population | |
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Insurance Data | |
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Hospital Data | |
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Diseases Treated in Special Clinics and Hospitals | |
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Data from Physicians' Practices | |
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Absenteeism Data | |
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School Health Programs | |
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Morbidity in the Armed Forces: Data on Active Personnel and Veterans | |
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Other Sources of Data Relevant to Epidemiologic Studies | |
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Conclusion | |
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Study Questions and Exercises | |
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Study Designs: Ecologic, Cross-Sectional, Case-Control | |
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Introduction | |
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Observational Versus Experimental Approaches in Epidemiology | |
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Overview of Study Designs Used in Epidemiology | |
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Ecologic Studies | |
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Cross-Sectional Studies | |
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Case-Control Studies | |
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Conclusion | |
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Study Questions and Exercises | |
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Study Designs: Cohort Studies | |
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Introduction | |
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Cohort Studies Defined | |
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Sampling and Cohort Formation Options | |
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Temporal Differences in Cohort Designs | |
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Practical Considerations | |
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Measures of Interpretation and Examples | |
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Nested Case-Control Studies | |
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Summary of Cohort Studies | |
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Comparisons of Observational Designs | |
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Conclusion | |
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Study Questions and Exercises | |
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Experimental Study Designs | |
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Introduction | |
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Hierarchy of Study Designs | |
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Intervention Studies | |
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Clinical Trials | |
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Community Trials | |
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Conclusion | |
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Study Questions and Exercises | |
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Measures of Effect | |
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Introduction | |
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Absolute Effects | |
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Relative Effects | |
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Statistical Measures of Effect | |
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Evaluating Epidemiologic Associations | |
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Conclusion | |
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Study Questions and Exercises | |
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Cohort Study Data for Coffee Use and Anxiety | |
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Data Interpretation Issues | |
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Introduction | |
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Validity of Study Designs | |
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Sources of Error in Epidemiologic Research | |
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Techniques to Reduce Bias | |
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Methods To Control Confounding | |
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Bias in Analysis and Publication | |
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Conclusion | |
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Study Questions and Exercises | |
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Screening for Disease in the Community | |
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Introduction | |
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Screening for Disease | |
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Appropriate Situations for Screening Tests and Programs | |
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Characteristics of a Good Screening Test | |
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Evaluation of Screening Tests | |
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Sources of Unreliability and Invalidity | |
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Measures of the Validity of Screening Tests | |
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Effects of Prevalence of Disease on Screening Test Results | |
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Relationship Between Sensitivity and Specificity | |
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Evaluation of Screening Programs | |
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Issues in the Classification of Morbidity and Mortality | |
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Conclusion | |
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Study Questions and Exercises | |
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Data for Problem 6 | |
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Epidemiology of Infectious Diseases | |
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Introduction | |
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Agents of Infectious Disease | |
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Characteristics of Infectious Disease Agents | |
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Host | |
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The Environment | |
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Means of Transmission-Directly or Indirectly from Reservoir | |
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Measures of Disease Outbreaks | |
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Procedures Used in the Investigation of Infectious Disease Outbreaks | |
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Epidemiologically Significant Infectious Diseases in the Community | |
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Conclusion | |
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Study Questions and Exercises | |
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Data from a Foodborne Illness Outbreak in a College Cafeteria | |
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Epidemiologic Aspects of Work and the Environment | |
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Introduction | |
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Health Effects Associated with Environmental Hazards | |
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Study Designs Used in Environmental Epidemiology | |
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Toxicologic Concepts Related to Environmental Epidemiology | |
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Types of Agents | |
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Environmental Hazards Found in the Work Setting | |
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Noteworthy Community Environmental Health Hazards | |
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Conclusion | |
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Study Questions and Exercises | |
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Molecular and Genetic Epidemiology | |
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Introduction | |
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Definitions and Distinctions: Molecular Versus Genetic Epidemiology | |
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Epidemiologic Evidence for Genetic Factors | |
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Causes of Familial Aggregation | |
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Shared Family Environment and Familial Aggregation | |
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Gene Mapping: Segregation and Linkage Analysis | |
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Application of Genes in Epidemiologic Designs | |
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Genetics and Public Health | |
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Conclusion | |
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Study Questions and Exercises | |
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Psychologic, Behavioral, and Social Epidemiology | |
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Introduction | |
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Research Designs Used in Psychologic, Behavioral, and Social Epidemiology | |
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The Social Context of Health | |
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Independent Variables | |
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Moderating Factors in the Stress-Illness Relationship | |
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Outcome Variables: Physical Health, Mental Health, Affective States | |
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Conclusion | |
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Study Questions and Exercises | |
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Guide to the Critical Appraisal of an Epidemiologic/Public Health Research Article | |
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Answers to Selected Study Questions | |
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Glossary | |
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Index | |