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Robustness and Evolvability in Living Systems

ISBN-10: 0691134049
ISBN-13: 9780691134048
Edition: 2005
Authors: Andreas Wagner
List price: $67.50 Buy it from $46.87
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Description: In spite of their enormous complexity, living things continue to function in the face of constant change. The reason is that evolution by natural selection preferentially finds and favours robust solutions to the problems organisms face in surviving  More...

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Book details

List price: $67.50
Copyright year: 2005
Publisher: Princeton University Press
Publication date: 7/22/2007
Binding: Paperback
Pages: 368
Size: 6.25" wide x 9.25" long x 1.25" tall
Weight: 1.430
Language: English

In spite of their enormous complexity, living things continue to function in the face of constant change. The reason is that evolution by natural selection preferentially finds and favours robust solutions to the problems organisms face in surviving and reproducing.

List of Figures
Acknowledgments
Introduction
Robustness Below the Gene Level
The Genetic Alphabet
The Genetic Code
RNA Structure
Proteins and Point Mutations
Proteins and Recombination
Robustness Above the Gene Level
Regulatory DNA Regions and Their Reorganization in Evolution
Metabolic Pathways
Metabolic Networks
Drosophila Segmentation and Other Gene Regulatory Networks
Phenotypic Traits, Cryptic Variation, and Human Diseases
The Many Ways of Building the Same Body
Common Principles
Neutral Spaces
Evolvability and Neutral Mutations
Redundancy of Parts or Distributed Robustness?
Robustness as an Evolved Adaptation to Mutations
Robustness as an Evolved Adaptation to Environmental Change and Noise
Robustness and Fragility: Advantages to Variation and Trade-offs
Robustness Beyond the Organism
Robustness in Natural Systems and Self-Organization
Robustness in Man-made Systems
Epilogue: Seven Open Questions for Systems Biology
Bibliography
Index

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