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| Preface | |
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| Series Preface | |
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| Organometallic Compounds in Biomedical Applications | |
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| Introduction | |
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| Case for Metal-Containing Bioactive Agents | |
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| Tin-Containing Biocidal Polymers | |
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| Ferrocene: A Therapeutic Role in Polymeric Systems? | |
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| Polymeric Moderation of OsO4 Toxicity | |
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| Miscellaneous Polymers | |
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| Metal Chelation Polymers | |
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| Condensation Polymers | |
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| Small-Molecule Analogs | |
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| Summary | |
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| References | |
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| Metal-Labeled DNA on Surfaces | |
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| Introduction | |
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| Ferrocene Nucleotides | |
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| Ferrocene-DNA Conjugates | |
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| Other Metal-DNA Conjugates | |
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| Metallated DNA | |
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| Cu-DNA | |
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| M-DNA | |
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| Summary | |
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| Acknowledgments | |
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| References | |
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| Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly | |
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| Introduction | |
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| Alternative Hydrogen-Bonding Schemes for DNA Base Pairing | |
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| Non-Hydrogen-Bonding Basepairs in DNA | |
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| Metal-Mediated Base Pairing in DNA | |
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| Basic Concept | |
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| Artificial Nucleosides Designed for Metal-Mediated Base Pairs | |
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| Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal Stability | |
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| Discrete Self-Assembled Metal Arrays in DNA | |
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| Future Prospects for Artificial Metallo-DNA | |
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| Summary | |
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| References | |
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| Organotin Macromolecules as Anticancer Drugs | |
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| General | |
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| Anticancer Activity of Small Organotin Compounds | |
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| Molecule-Level Studies on Monomeric Organotin Compounds | |
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| Anticancer Activity of Organotin Polymers | |
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| Future Work | |
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| References | |
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| Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir | |
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| Early History of Organotin Compounds | |
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| Mechanisms and Reactions | |
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| General Structures | |
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| Acyclovir | |
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| Bioactivity of Related Compounds | |
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| Experimental Work | |
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| Results and Discussion | |
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| References | |
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| Polymeric Ferrocene Conjugates as Antiproliferative Agents | |
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| Introduction | |
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| The Ferrocene-Ferricenium System in the Biological Environment | |
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| Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery | |
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| Polymer-Ferrocene Conjugates: Synthesis and Structure | |
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| The Carrier Component: Structural Considerations | |
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| Conjugates of Amide-Linked Ferrocene | |
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| Conjugates of Ester-Linked Ferrocene | |
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| Bioactivity Screening | |
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| Summary and Conclusions | |
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| Acknowledgments | |
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| VIII | |
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| Polymeric Platinum-Containing Drugs in the Treatment of Cancer | |
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| Introduction | |
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| Basic Mechanisms of Pt(II) Complex Formation | |
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| Nomenclature | |
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| Currently Approved Platinum-Containing Compounds | |
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| Properties of Cisplatin | |
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| Structure-Activity Relationships | |
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| Polymer-Drug Conjugation Strategy and Possible Benefits | |
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| Polymers as Carriers | |
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| Polymers as Drugs | |
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| General | |
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| Mainchain-Incorporated cis-Diamine-Coordinated Platinum | |
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| Simple Amine Derivatives | |
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| Amino Acid Derivatives | |
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| Other Nitrogen-Platinum Products | |
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| Solution Stability | |
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| Thermal Stability | |
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| Antiviral Activity | |