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Instrumentation | |
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Basics of Mass Spectrometry | |
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A Brief History of Mass Spectrometry | |
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Unique Features of Mass Spectrometry | |
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Basic Principles of Mass Spectrometry | |
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Anatomy of a Mass Spectrum | |
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Atomic and Molecular Masses | |
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Mass-to-charge Ratio | |
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General Applications | |
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Overview of the Chapter | |
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Excercises | |
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References | |
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Modes of Ionization | |
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Why Ionization is Required? | |
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General Construction of the Ion Source | |
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Gas-Phase Ionization Techniques | |
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Electron Ionization | |
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Chemical Ionization | |
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Charge-exchange Chemical Ionization | |
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Negative-Ion Chemical Ionization | |
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Photoionization | |
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Field Ioniztion | |
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Metastable Atom Bombardment Ionization | |
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Condensed-phase Ionization Techniques: Ionization of | |
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Solid-State Samples | |
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Field Desorption | |
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Plasma Desorption Ionization | |
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Secondary-ion Mass Spectrometry | |
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Fast Atom Bombardment | |
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Laser Desorption/Ionization | |
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Matrix-Assisted Laser Desorption/Ionization | |
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Analysis of Low Molecular Mass Compounds | |
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Atmospheric Pressure | |
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Surface-enhanced Laser Desorption/Ionization | |
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Condensed-phase Ionization Techniques: Ionization of Liquid-State Samples | |
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Thermospray Ionization | |
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Atmospheric Pressure Chemical Ionization | |
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Atmospheric Pressure Photoionization | |
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Electrospray Ionization | |
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Mechanism of Electrospray Ionization | |
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Sample Consideration | |
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Nanoelectrospray Ionization | |
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Desorption Electrospray Ionization | |
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DART Ion Source | |
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OVerview of the Chapter | |
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Exercises | |
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Additional Reading | |
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References | |
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Mass Analysis and Ion Detection | |
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Mass Resolution | |
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Kinetic Energy of Ions | |
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Mass Analyzers | |
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Magnetic Sector Mass Spectrometers | |
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Working Principle of a Magnetic Analyzer | |
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Working Principle of an Electrostatic Analyzer | |
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Working Principle of Double-Focusing Magnetic Sector Mass Spectrometers | |
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Performance Characteristics | |
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Quadrupole Mass Spcetrometers | |
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Working Principle | |
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Performance Characteristics | |
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RF-only quadrupole | |
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Time-of-Flight Mass Spectrometers | |
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Working Principle | |
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Delayed Extraction of Ions | |
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Reflectron TOF Instrument | |
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Orthogonal Acceleration TOF Mass Spectrometer | |
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Performance Characteristics | |
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Quadrupole Ion Trap Mass Spectrometers | |
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Working Principle | |
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Operational Modes | |
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Performance Characteristics | |
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Linear Ion Trap Mass Spectrometers | |
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Rectilinear Ion Trap | |
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Fourier-Transform Ion Cyclotron Resonance Mass Spectrometers | |
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Working Principle | |
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Performance Characteristics | |
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Orbitrap Mass Analyzer | |
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Ion Mobility Mass Spectrometers | |
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Detectors | |
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Faraday Cup Detector | |
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Electron Multipliers | |
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Photomultiplier detectors | |
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Post-acceleration Detectors | |
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Low-temperature Calorimetric Detectors for High Mass Ions | |
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Focal-plane Detectors | |
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Overview of the Chapter | |
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Excercises | |
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Additional Reading | |
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References | |
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Tandem Mass Spectrometry | |
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Basic Principles of Tandem Mass Spectrometry | |
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Types of Scan Functions | |
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Ion Activation and Dissociation | |
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Collision-induced Dissociation | |
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Surface-induced Dissociation | |
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Absorption of Electromagnetic Radiations | |
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Electron-capture Dissociation | |
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Reactions in Tandem Mass Spectrometry | |
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Tandem Mass Spectrometry Instrumentation | |
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Magnetic Sector Tandem Mass Spectrometers | |
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Tandem Mass Spectrometry with Multiple Quadrupole Devices | |
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Tandem Mass Spectrometry with Time-of-Flight Instruments | |
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Tandem Mass Spectrometry with a Quadrupole Ion Trap Mass Spectrometer | |
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Tandem Mass Spectrometry with an FT-ICR Mass Spectrometer | |
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Tandem Mass Spectrometry with Hybrid Instruments | |
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Overview of the Chapter | |
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Excercises | |
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Additional Reading | |
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References | |
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Hyphenated Separation Techniques | |
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Benefits of the Coupling of Separation Devices with Mas | |