Introduction to Tissue-Biomaterial Interactions

ISBN-10: 0471253944
ISBN-13: 9780471253945
Edition: 2002
List price: $187.95 Buy it from $168.75
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Description: Tissue-Biomaterial Interactions focuses on events that take place at the interface between living tissue and biomaterials. The authors explain the current understanding of cell and tissue behaviour and describe recent developments in biomaterials.

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Book details

List price: $187.95
Copyright year: 2002
Publisher: John Wiley & Sons, Incorporated
Publication date: 9/2/2002
Binding: Hardcover
Pages: 248
Size: 7.28" wide x 10.35" long x 0.78" tall
Weight: 1.672
Language: English

Tissue-Biomaterial Interactions focuses on events that take place at the interface between living tissue and biomaterials. The authors explain the current understanding of cell and tissue behaviour and describe recent developments in biomaterials.

Preface
Acknowledgments
Introduction
Biomaterials
Introduction
Definition
Metallic Biomaterials
Basis of Structure-Property Relationships
Corrosion
Mechanical Properties
Ceramic and Glass Biomaterials
Basis of Structure-Property Relationships
Degradation
Mechanical Properties
Polymeric Biomaterials
Basis of Structure-Property Relationships
Degradation
Mechanical Properties
Choice of Materials for Biomedical Applications
Biomaterials for Implantable Devices: Present and Future Directions
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions
Proteins
Introduction
Primary Structure
Secondary Structure
Tertiary Structure
Quaternary Structure
Importance of Conformation
Examples
Collagen
Elastin
Fibronectin
Fibrinogen
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions/Discovery Activities
Protein-Surface Interactions
Introduction
Important Protein and Surface Properties
Protein Properties
Surface Properties
Adsorption and Desorption
Conformational Changes
Multicomponent Solutions
Example--Blood-Surface Interactions
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions/Discovery Activities
Blood-Biomaterial Interactions and Coagulation
Introduction
The Blood Cell Source: Marrow and Stem Cells
Red Blood Cells
Formation and Function
Deformation and Blood Flow
Platelets
Formation and Function
Platelet Aggregation and the Process of Coagulation
The Coagulation Cascades
Mechanisms
Control Points
Anticoagulants and Fibrinolysis
Biomaterials, Devices, and Thrombosis
Summary
Bibliography/Suggested Reading
Study Questions
Discovery Activities
Inflammation and Infection
Introduction
Historical Observations: Inflammation and Infection
Nonlymphatic Leukocytes
Inflammation and Leukocyte Functions
Chemotaxis and Cell Migration
Phagocytosis
Diapedesis
Physiological Explanations for the Cardinal Signs
Infection
Summary
References
Bibliography/Suggested Reading
Study Questions
Discovery Activities
The Immune System and Inflammation
Introduction
Lymphocytes
Immunogens, Antigens, and Antibodies
Cell-Mediated Immunity
T Cell Subpopulations and Functions
Antigen-Presenting Cells
Humoral Immunity
B Cell Subpopulations and Functions
The Complement System
Generating Specificity
Clonal Selection Theory
"Self" Versus "Non-self"?
Summary
Bibliography/Suggested Reading
Study Questions
Discovery Activities
Wound Healing
Introduction
Tissues
The Biology of Wound Healing of Vascularized Connective Tissue in Adults
Pertinent Aspects of Hemostasis and Inflammation
Proliferative and Repair Phase
Remodeling Phase
Scar Tissue
Timing Aspects
Factors that Affect the Wound Healing Outcome
An Example of Wound Healing Tissue: Skin
Chronic Nonhealing Wounds
Wound Healing Around Implants in Adults
Complications Related to Wound Healing Around Implants
Closing Remarks
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions
Biomaterial Surfaces and the Physiological Environment
Introduction
Surface Characterization Methods
Contact Angle Analysis
X-Ray Photoelectron Spectroscopy (XPS)
Fourier Transform Infrared (FTIR) Spectroscopy
Secondary Ion Mass Spectroscopy (SIMS)
Scanning Electron Microscopy (SEM)
Atomic Force Microscopy (AFM)
Surface Responses to the Wound Healing Process
Protein Fouling
Degradation and Dissolution
Calcification
Engineering Biomaterial Surfaces
Morphologic Modifications
Physicochemical Modifications
Biological Modifications
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions/Discovery Activities
Biocompatibility
Introduction
Differences between Biological and Synthetic Materials
Tests Prerequisite to Evaluation of Biocompatibility
Methods for Testing and Evaluating Biocompatibility
In Vitro Testing
Animal Models
Clinical Trials
Attempting to Define Biocompatibility
Concluding Remarks
Summary
Bibliography/Suggested Reading
Quiz Questions
Study Questions
Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia
Replacing Joints and Teeth
Answers to Quiz Questions
Glossary
Index

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