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Preface | |
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Acknowledgments | |
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Introduction | |
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Biomaterials | |
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Introduction | |
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Definition | |
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Metallic Biomaterials | |
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Basis of Structure-Property Relationships | |
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Corrosion | |
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Mechanical Properties | |
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Ceramic and Glass Biomaterials | |
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Basis of Structure-Property Relationships | |
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Degradation | |
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Mechanical Properties | |
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Polymeric Biomaterials | |
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Basis of Structure-Property Relationships | |
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Degradation | |
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Mechanical Properties | |
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Choice of Materials for Biomedical Applications | |
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Biomaterials for Implantable Devices: Present and Future Directions | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions | |
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Proteins | |
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Introduction | |
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Primary Structure | |
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Secondary Structure | |
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Tertiary Structure | |
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Quaternary Structure | |
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Importance of Conformation | |
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Examples | |
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Collagen | |
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Elastin | |
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Fibronectin | |
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Fibrinogen | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions/Discovery Activities | |
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Protein-Surface Interactions | |
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Introduction | |
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Important Protein and Surface Properties | |
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Protein Properties | |
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Surface Properties | |
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Adsorption and Desorption | |
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Conformational Changes | |
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Multicomponent Solutions | |
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Example--Blood-Surface Interactions | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions/Discovery Activities | |
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Blood-Biomaterial Interactions and Coagulation | |
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Introduction | |
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The Blood Cell Source: Marrow and Stem Cells | |
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Red Blood Cells | |
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Formation and Function | |
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Deformation and Blood Flow | |
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Platelets | |
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Formation and Function | |
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Platelet Aggregation and the Process of Coagulation | |
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The Coagulation Cascades | |
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Mechanisms | |
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Control Points | |
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Anticoagulants and Fibrinolysis | |
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Biomaterials, Devices, and Thrombosis | |
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Summary | |
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Bibliography/Suggested Reading | |
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Study Questions | |
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Discovery Activities | |
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Inflammation and Infection | |
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Introduction | |
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Historical Observations: Inflammation and Infection | |
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Nonlymphatic Leukocytes | |
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Inflammation and Leukocyte Functions | |
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Chemotaxis and Cell Migration | |
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Phagocytosis | |
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Diapedesis | |
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Physiological Explanations for the Cardinal Signs | |
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Infection | |
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Summary | |
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References | |
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Bibliography/Suggested Reading | |
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Study Questions | |
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Discovery Activities | |
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The Immune System and Inflammation | |
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Introduction | |
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Lymphocytes | |
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Immunogens, Antigens, and Antibodies | |
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Cell-Mediated Immunity | |
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T Cell Subpopulations and Functions | |
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Antigen-Presenting Cells | |
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Humoral Immunity | |
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B Cell Subpopulations and Functions | |
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The Complement System | |
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Generating Specificity | |
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Clonal Selection Theory | |
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"Self" Versus "Non-self"? | |
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Summary | |
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Bibliography/Suggested Reading | |
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Study Questions | |
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Discovery Activities | |
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Wound Healing | |
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Introduction | |
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Tissues | |
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The Biology of Wound Healing of Vascularized Connective Tissue in Adults | |
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Pertinent Aspects of Hemostasis and Inflammation | |
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Proliferative and Repair Phase | |
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Remodeling Phase | |
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Scar Tissue | |
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Timing Aspects | |
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Factors that Affect the Wound Healing Outcome | |
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An Example of Wound Healing Tissue: Skin | |
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Chronic Nonhealing Wounds | |
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Wound Healing Around Implants in Adults | |
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Complications Related to Wound Healing Around Implants | |
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Closing Remarks | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions | |
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Biomaterial Surfaces and the Physiological Environment | |
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Introduction | |
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Surface Characterization Methods | |
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Contact Angle Analysis | |
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X-Ray Photoelectron Spectroscopy (XPS) | |
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Fourier Transform Infrared (FTIR) Spectroscopy | |
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Secondary Ion Mass Spectroscopy (SIMS) | |
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Scanning Electron Microscopy (SEM) | |
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Atomic Force Microscopy (AFM) | |
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Surface Responses to the Wound Healing Process | |
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Protein Fouling | |
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Degradation and Dissolution | |
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Calcification | |
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Engineering Biomaterial Surfaces | |
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Morphologic Modifications | |
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Physicochemical Modifications | |
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Biological Modifications | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions/Discovery Activities | |
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Biocompatibility | |
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Introduction | |
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Differences between Biological and Synthetic Materials | |
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Tests Prerequisite to Evaluation of Biocompatibility | |
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Methods for Testing and Evaluating Biocompatibility | |
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In Vitro Testing | |
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Animal Models | |
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Clinical Trials | |
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Attempting to Define Biocompatibility | |
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Concluding Remarks | |
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Summary | |
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Bibliography/Suggested Reading | |
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Quiz Questions | |
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Study Questions | |
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Opening Occluded Vessels: Vascular Grafts, Intimal Hyperplasia | |
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Replacing Joints and Teeth | |
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Answers to Quiz Questions | |
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Glossary | |
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Index | |