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| Introduction and Background | |
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| Life | |
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| Prokaryotes | |
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| Eukaryotes | |
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| Biochemistry: A Prologue | |
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| Genetics: A Review | |
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| The Origin of Life | |
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| The Biochemical Literature | |
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| Aqueous Solutions | |
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| Properties of Water | |
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| Acids, Bases, and Buffers | |
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| Thermodynamic Principles: A Review | |
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| First Law of Thermodynamics: Energy Is Conserved | |
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| Second Law of Thermodynamics: The Universe Tends toward Maximum Disorder | |
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| Free Energy: The Indicator of Spontaneity | |
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| Chemical Equilibria | |
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| Concentration Dependence of Free Energy | |
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| Biomolecules | |
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| Amino Acids | |
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| The Amino Acids of Proteins | |
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| Optical Activity | |
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| "Nonstandard" Amino Acids | |
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| Nucleic Acids, Gene Expression, and Recombinant DNA Technology | |
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| Nucleotides and Nucleic Acids | |
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| DNA Is the Carrier of Genetic Information | |
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| Double Helical DNA | |
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| Gene Expression and Replication: An Overview | |
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| Molecular Cloning | |
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| Techniques of Protein and Nucleic Acid Purification | |
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| Protein Isolation | |
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| Solubilities of Proteins | |
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| Chromatographic Separations | |
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| Electrophoresis | |
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| Ultracentrifugation | |
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| Nucleic Acid Fractionation | |
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| Covalent Structures of Proteins and Nucleic Acids | |
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| Primary Structure Determination of Proteins | |
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| Nucleic Acid Sequencing | |
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| Chemical Evolution | |
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| Bioinformatics: An Introduction | |
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| Chemical Synthesis of Polypeptides | |
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| Chemical Synthesis of Oligonucleotides | |
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| Three-Dimensional Structures of Proteins | |
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| Secondary Structure | |
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| Fibrous Proteins | |
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| Globular Proteins | |
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| Protein Stability | |
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| Quaternary Structure | |
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| Viewing Stereo Pictures | |
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| Protein Folding, Dynamics, and Structural Evolution | |
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| Protein Folding: Theory and Experiment | |
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| Folding Accessory Proteins | |
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| Protein Structure Prediction and Design | |
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| Protein Dynamics | |
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| Conformational Diseases: Amyloids and Prions | |
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| Structural Evolution | |
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| Hemoglobin: Protein Function in Microcosm | |
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| Hemoglobin Function | |
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| Structure and Mechanism | |
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| Abnormal Hemoglobins | |
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| Allosteric Regulation | |
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| Derivation of Symmetry Model Equations | |
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| Sugars and Polysaccharides | |
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| Monosaccharides | |
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| Polysaccharides | |
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| Glycoproteins | |
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| Lipids and Membranes | |
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| Lipid Classification | |
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| Properties of Lipid Aggregates | |
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| Biological Membranes | |
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| Membrane Assembly and protein Targeting | |
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| Lipoproteins | |
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| Mechanisms of Enzyme Action | |
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| Introduction to Enzymes | |
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| Historical Perspective | |
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| Substrate Specificity | |
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| Coenzymes | |
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| Regulation of Enzymatic Activity | |
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| A Primer of Enzyme Nomenclature | |
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| Rates of Enzymatic Reactions | |
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| Chemical Kinetics | |
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| Enzyme Kinetics | |
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| Inhibition | |
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| Effects of pH | |
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| Bisubstrate Reactions | |
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| Derivations of Michaelis-Menten Equation Variants | |
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| Enzymatic Catalysis | |
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| Catalytic Mechanisms | |
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| Lysozyme | |
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| Serine Proteases | |
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| Drug Design | |
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| Metabolism | |
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| Introduction to Metabolism | |
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| Metabolic Pathways | |
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| Organic Reaction Mechanisms | |
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| Experimental Approaches to the Study of Metabolism | |
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| Thermodynamics of Phosphate Compounds | |
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| Oxidation-Reduction Reactions | |
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| Thermodynamics of Life | |
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| Glycolysis | |
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| The Glycolytic Pathway | |
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| The Reactions of Glycolysis | |
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| Fermentation: The Anaerobic Fate of Pyruvate | |
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| Metabolic Regulation and Control | |
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| Metabolism of Hexoses Other than Glucose | |
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| Glycogen Metabolism | |
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| Glycogen Breakdown | |
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| Glycogen Synthesis | |
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| Control of Glycogen Metabolism | |
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| Glycogen Storage Diseases | |
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| Signal Transduction | |
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| Hormones | |
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| Heterotrimeric G Proteins | |
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| Tyrosine Kinase-Based Signaling | |
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| The Phosphoinositide Cascade | |
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| Transport through Membranes | |
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| Thermodynamics of Transport | |
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| Kinetics and Mechanisms of Transport | |
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| ATP-Driven Active Transport | |
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| Ion Gradient-Driven Active Transport | |
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| Neurotransmission | |
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| Citric Acid Cycle | |
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| Cycle Overview | |
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| Metabolic Sources of Acetyl-Coenzyme A | |
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| Enzymes of the Citric Acid Cycle | |
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| Regulation of the Citric Acid Cycle | |
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| The Amphibolic Nature of the Citric Acid Cycle | |
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| Electron Transport and Oxidative Phosphorylation | |
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| The Mitochondrion | |
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| Electron Transport | |
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| Oxidative Phosphorylation | |
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| Control of ATP Production | |
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| Other Pathways of Carbohydrate Metabolism | |
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| Gluconeogenesis | |
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| The Glyoxylate Cycle | |
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| Biosynthesis of Oligosaccharides and Glycoproteins | |
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| The Pentose Phosphate Pathway | |
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| Photosynthesis | |
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| Chloroplasts | |
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| Light Reactions | |
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| Dark Reactions | |
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| Lipid Metabolism | |
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| Lipid Digestion, Absorption, and Transport | |
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| Fatty Acid Oxidation | |
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| Ketone Bodies | |
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| Fatty Acid Biosynthesis | |
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| Regulation of Fatty Acid Metabolism | |
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| Cholesterol Metabolism | |
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| Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins | |
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| Phospholipid and Glycolipid Metabolism | |
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| Amino Acid Metabolism | |
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| Amino Acid Deamination | |
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| The Urea Cycle | |
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| Metabolic Breakdown of Individual Amino Acids | |
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| Amino Acids as Biosynthetic Precursors | |
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| Amino Acid Biosynthesis | |
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| Nitrogen Fixation | |
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| Energy Metabolism: Integration and Organ Specialization | |
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| Major Pathways and Strategies of Energy Metabolism: A Summary | |
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| Organ Specialization | |
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| Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight | |
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| Metabolic Adaptation | |
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| Nucleotide Metabolism | |
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| Synthesis of Purine Ribonucleotides | |
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| Synthesis of Pyrimidine Ribonucleotides | |
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| Formation of Deoxyribonucleotides | |
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| Nucleotide Degradation | |
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| Biosynthesis of Nucleotide Coenzymes | |
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| Expression and Transmission of Genetic Information | |
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| Nucleic Acid Structures | |
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| Double Helical Structures | |
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| Forces Stabilizing Nucleic Acid Structures | |
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| Supercoiled DNA | |
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| DNA Replication, Repair, and Recombination | |
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| DNA Replication: An Overview | |
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| Enzymes of Replication | |
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| Prokaryotic Replication | |
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| Eukaryotic Replication | |
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| Repair of DNA | |
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| Recombination and Mobile Genetic Elements | |
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| DNA Methylation and Trinucleotide Repeat Expansions | |
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| Transcription | |
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| The Role of RNA in Protein Synthesis | |
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| RNA Polymerase | |
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| Control of Transcription in Prokaryotes | |
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| Posttranscriptional Processing | |
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| Translation | |
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| The Genetic Code | |
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| Transfer RNA and Its Aminoacylation | |
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| Ribosomes and Polypeptide Synthesis | |
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| Control of Eukaryotic Translation | |
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| Posttranslational Modification | |
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| Protein Degradation | |
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| Viruses: Paradigms for Cellular Function | |
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| Tobacco Mosaic Virus | |
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| Icosahedral Viruses | |
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| Bacteriophage [lambda] | |
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| Influenza Virus | |
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| Eukaryotic Gene Expression | |
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| Chromosome Structure | |
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| Genomic Organization | |
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| Control of Expression | |
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| Cell Differentiation and Growth | |
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| Molecular Physiology | |
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| Blood Clotting | |
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| Immunity | |
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| Motility: Muscles, Cilia, and Flagella | |
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| Index | |