Bioanorganische Chemie

ISBN-10: 0470975237
ISBN-13: 9780470975237
Edition: 2nd 2013
List price: $83.00
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Description: Bioinorganic Chemistry provides a clear and concise introduction to the role of inorganic elements in biology. Starting with the function and occurrence of inorganic elements in living organisms, the book moves on to address the applications of  More...

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Book details

List price: $83.00
Edition: 2nd
Copyright year: 2013
Publisher: John Wiley & Sons Canada, Limited
Publication date: 10/14/2013
Binding: Paperback
Pages: 426
Size: 7.44" wide x 9.69" long x 1.00" tall
Weight: 1.980
Language: English

Bioinorganic Chemistry provides a clear and concise introduction to the role of inorganic elements in biology. Starting with the function and occurrence of inorganic elements in living organisms, the book moves on to address the applications of these biominerals, inorganic electrolytes and inorganic compounds in fields such as chemotherapy and radiodiagnostics. Topics covered include: cobalt in vitamin and coenzyme B12 the role of magnesium and manganese in photosynthesis uptake, transport, and storage of essential elements catalysis through hemoproteins iron-sulfur and other non-heme iron proteins nickel-containing enzymes copper-containing proteins biological functions of molybdenum, tungsten, vanadium and chromium structural and gene-regulatory functions of zinc and its role in the enzymatic catalysis of function and transport of alkali and alkaline earth metal cations catalysis and regulation of bioenergetic processes by the alkaline earth metal ions Mg2+ and Ca2+ biomineralization biological functions of the non-metallic inorganic elements bioinorganic chemistry of toxic metals biochemical behaviour of inorganic radionucleides chemotherapy whith compounds of non-essential elements This second edition has been fully revised and updated to take account of the latest findings in the field. New topics have been added, including neurotransmitter gases such as NO; life under extreme conditions; materials aspect of bioinorganic chemistry; elemental cycles; bioorganometallic chemistry; imaging with bioinorganic substances; and therapeutic advances. Bioinorganic Chemistry is essential reading for advanced students of chemistry, biochemistry, biology, medicine and environmental science.

Preface to the Second Edition
Preface to the First Edition
Historical Background, Current Relevance and Perspectives
References
Some General Principles
Occurrence and Availability of Inorganic Elements in Organisms
Insertion: The Chelate Effect
Insertion: "Hard" and "Soft" Coordination Centers
Biological Functions of Inorganic Elements
Biological Ligands for Metal Ions
Coordination by Proteins-Comments on Enzymatic Catalysis
Insertion: The "Entatic State" in Enzymatic Catalysis
Tetrapyrrole Ligands and Other Macrocycles
Insertion: Electron Spin States in Transition Metal Ions
Nucleobases, Nucleotides and Nucleic Acids (RNA, DNA) as Ligands
Insertion: Secondary Bonding
Relevance of Model Compounds
References
Cobalamins, Including Vitamin and Coenzyme B<sub>12</sub>
History and Structural Characterization
Insertion: Bioorganometallics I
General Reactions of Alkylcobalamins
One-electron Reduction and Oxidation
Co-C Bond Cleavage
Insertion: Electron Paramagnetic Resonance I
Enzyme Functions of Cobalamins
Adenosylcobalamin (AdoCbl)-dependent Isomerases
Insertion: Organic Redox Coenzymes
Alkylation Reactions of Methylcobalamin (MeCbl)-dependent Alkyl Transferases
Model Systems and the Enzymatic Activation of the Co-C Bond
References
Metals at the Center of Photosynthesis: Magnesium and Manganese
Volume and Efficiency of Photosynthesis
Primary Processes in Photosynthesis
Light Absorption (Energy Acquisition)
Exciton Transport (Directed Energy Transfer)
Charge Separation and Electron Transport
Insertion: Structure Determination by X-ray Diffraction
Manganese-catalyzed Oxidation of Water to O<sub>2</sub>
Insertion: Spin-Spin Coupling
References
The Dioxygen Molecule, O<sub>2</sub>: Uptake, Transport and Storage of an Inorganic Natural Product
Molecular and Chemical Properties of Dioxygen, O<sub>2</sub>
Oxygen Transport and Storage through Hemoglobin and Myoglobin
Alternative Oxygen Transport in Some Lower Animals: Hemerythrin and Hemocyanin
Magnetism
Light Absorption
Vibrational Spectroscopy
Insertion: Resonance Raman Spectroscopy
M�ssbauer Spectroscopy
Insertion: M�ssbauer Spectroscopy
Structure
Conclusion
References
Catalysis through Hemoproteins: Electron Transfer, Oxygen Activation and Metabolism of Inorganic Intermediates
Cytochromes
Cytochrome P-450: Oxygen Transfer from O<sub>2</sub> to Nonactivated Substrates
Peroxidases: Detoxification and Utilization of Doubly Reduced Dioxygen
Controlling the Reaction Mechanism of the Oxyheme Group: Generation and Function of Organic Free Radicals
Hemoproteins in the Catalytic Transformation of Partially Reduced Nitrogen and Sulfur Compounds
Insertion: Gasotransmitters
References
Iron-Sulfur and Other Non-heme Iron Proteins
Biological Relevance of the Element Combination Iron-Sulfur
Insertion: Extremophiles and Bioinorganic Chemistry
Rubredoxins
[2Fe-2S] Centers
Polynuclear Fe/S Clusters: Relevance of the Protein Environment and Catalytic Activity
Model Systems for Fe/S Proteins
Iron-containing Enzymes without Porphyrin or Sulfide Ligands
Iron-containing Ribonucleotide Reductase
Soluble Methane Monooxygenase
Purple Acid Phosphatases (Fe/Fe and Fe/Zn)
Mononuclear Non-heme Iron Enzymes
References
Uptake, Transport and Storage of an Essential Element, as Exemplified by Iron
Insertion: Metallome
The Problem of Iron Mobilization: Oxidation States, Solubility and Medical Relevance
Siderophores: Iron Uptake by Microorganisms
Insertion: Optical Isomerism in Octahedral Complexes
Phytosiderophores: Iron Uptake by Plants
Transport and Storage of Iron
Transferrin
Ferritin
Hemosiderin
References
Nickel-containing Enzymes: The Remarkable Career of a Long-overlooked Biometal
Overview
Urease
Hydrogenases
CO Dehydrogenase = CO Oxidoreductase = Acetyl-CoA Synthase
Methyl-coenzyme M Reductase (Including the F<sub>430</sub> Cofactor)
Insertion: Natural and Artificial (Industrial) C<sub>1</sub> Chemistry
Insertion: Bioorganometallics II: The Organometallic Chemistry of Cobalt and Nickel
Superoxide Dismutase
Model Compounds
Further Reading
References
Copper-containing Proteins: An Alternative to Biological Iron
Type 1: "Blue" Copper Proteins
Insertion: Electron Paramagnetic Resonance II
Type 2 and Type 3 Copper Centers in O<sub>2</sub>-activating Proteins: Oxygen Transport and Oxygenation
Copper Proteins as Oxidases/Reductases
Cytochrome c Oxidase
Cu,Zn-and Other Superoxide Dismutases: Substrate-specific Antioxidants
References
Biological Functions of the "Early" Transition Metals: Molybdenum, Tungsten, Vanadium and Chromium
Oxygen Transfer through Tungsten-and Molybdenum-containing Enzymes
Overview
Oxotransferase Enzymes Containing the Molybdopterin or Tungstopterin Cofactor
Insertion: "Oxidation"
Metalloenzymes in the Biological Nitrogen Cycle: Molybdenum-dependent Nitrogen Fixation
Alternative Nitrogenases
Biological Vanadium Outside of Nitrogenases
Chromium(III) in the Metabolism?
References
Zinc: Structural and Gene-regulatory Functions and the Enzymatic Catalysis of Hydrolysis and Condensation Reactions
Overview
Carboanhydrase
Carboxypeptidase A and Other Hydrolases
Catalysis of Condensation Reactions by Zinc-containing Enzymes
Alcohol Dehydrogenase and Related Enzymes
The "Zinc Finger" and Other Gene-regulatory Zinc Proteins
Insulin, hGH, Metallothionein and DNA Repair Systems as Zinc-containing Proteins
References
Unequally Distributed Electrolytes: Function and Transport of Alkali and Alkaline Earth Metal Cations
Characterization and Biological Roles of K<sup>+</sup>, Na<sup>+</sup>, Ca<sup>2+</sup> and Mg<sup>2+</sup>
Insertion: Heteroatom Nuclear Magnetic Resonance
Complexes of Alkali and Alkaline Earth Metal Ions with Macrocycles
Ion Channels
Ion Pumps
Further Reading
References
Catalysis and Regulation of Bioenergetic Processes by the Alkaline Earth Metal Ions Mg<sup>2+</sup> and Ca<sup>2+</sup>
Magnesium: Catalysis of Phosphate Transfer by Divalent Ions
The Ubiquitous Regulatory Role of Ca<sup>2+</sup>
Further Reading
References
Biomineralization: The Controlled Assembly of "Advanced Materials" in Biology
Overview
Nucleation and Crystal Growth
Insertion: Dimensions
Examples of Biominerals
Calcium Phosphate in the Bones of Vertebrates and the Global P Cycle
Insertion: The Global P Cycle
Calcium Carbonate and the Global Inorganic C Cycle
Insertion: The Global C Cycle and the Marine Inorganic C Cycle
Amorphous Silica
Iron Biominerals
Strontium and Barium Sulfates
Biomimetic Materials
Further Reading
References
Biological Functions of the Nonmetallic Inorganic Elements
Overview
Boron
Silicon
Arsenic and Trivalent Phosphorus
Bromine
Fluorine
Iodine
Selenium
References
The Bioinorganic Chemistry of the Quintessentially Toxic Metals
Overview
Lead
Cadmium
Thallium
Mercury
Aluminum
Beryllium
Chromium and Tungsten
Toxicity of Nanomaterials
Further Reading
References
Biochemical Behavior of Radionuclides and Medical Imaging Using Inorganic Compounds
Radiation Risks and Medical Benefits from Natural and Synthetic Radionuclides
The Biochemical Impact of Ionizing Radiation from Radioactive Isotopes
Natural and Synthetic Radioisotopes
Bioinorganic Chemistry of Radionuclides
Insertion: Fukushima Daiichi, Chernobyl, Hiroshima and Nuclear Weapons Testing
Radiopharmaceuticals
Technetium: A "Synthetic Bioinorganic Element"
Radiotracers for the Investigation of the Metallome
Medical Imaging Based on Nonradioactive Inorganic Compounds
Magnetic Resonance Imaging
X-ray Contrast Agents
Further Reading
References
Chemotherapy Involving Nonessential Elements
Overview
Platinum Complexes in Cancer Therapy
Discovery, Application and Structure-Effect Relationships
Cisplatin: Mode of Action
New Anticancer Drugs Based on Transition Metal Complexes
Overview and Aims for Drug Development
Nonplatinum Anticancer Drugs
Further Inorganic Compounds in (Noncancer) Chemotherapy
Gold-containing Drugs Used in the Therapy of Rheumatoid Arthritis
Lithium in Psychopharmacologic Drugs
Bismuth Compounds against Ulcers
Vanadium-containing Insulin Mimetics and V-containing Anti-HTV Drags
Sodium Nitroprusside
Bioorganometallic Chemistry of Nonessential Elements
Further Reading
References
Index

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