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| The Science of Genetics | |
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| An Invitation | |
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| Three Great Milestones in Genetics | |
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| DNA as the Genetic Material | |
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| Genetics and Evolution | |
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| Levels of Genetic Analysis | |
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| Genetics in the World: Applications of Genetics to Human Endeavors | |
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| Cellular Reproduction | |
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| Cells and Chromosomes | |
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| Mitosis | |
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| Meiosis | |
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| Life Cycles of Some Model Genetic Organisms | |
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| Mendelism: The Basic Principles of Inheritance | |
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| Mendel���s Study of Heredity | |
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| Applications of Mendel���s Principles | |
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| Testing Genetic Hypotheses | |
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| Mendelian Principles in Human Genetics | |
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| Extensions of Mendelism | |
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| Allelic Variation and Gene Function | |
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| Gene Action: From Genotype to Phenotype | |
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| Inbreeding: Another Look at Pedigrees | |
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| The Chromosomal Basis of Mendelism | |
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| Chromosomes | |
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| The Chromosome Theory of Heredity | |
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| Sex-Linked Genes in Humans | |
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| Sex Chromosomes and Sex | |
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| Determination | |
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| Dosage Compensation of X-Linked Genes | |
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| Variation in Chromosome Number and Structure | |
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| Cytological Techniques | |
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| Polyploidy | |
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| Aneuploidy | |
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| Rearrangements of Chromosome Structure | |
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| Linkage, Crossing Over, and Chromosome Mapping in Eukaryotes | |
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| Linkage, Recombination, and Crossing Over | |
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| Chromosome Mapping | |
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| Cytogenetic Mapping | |
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| Linkage Analysis in Humans | |
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| Recombination and Evolution | |
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| The Genetics of Bacteria and Their Viruses | |
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| Viruses and Bacteria in Genetics | |
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| The Genetics of Viruses | |
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| The Genetics of Bacteria | |
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| Mechanisms of Genetic Exchange in Bacteria | |
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| The Evolutionary Significance of Genetic Exchange in Bacteria | |
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| DNA and the Molecular Structure of Chromosomes | |
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| Functions of the Genetic Material | |
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| Proof That Genetic Information Is Stored in DNA | |
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| The Structures of DNA and RNA | |
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| Chromosome Structure in Prokaryotes and Viruses | |
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| Chromosome Structure in Eukaryotes | |
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| Replication of DNA and Chromosomes | |
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| Basic Features of DNA Replication In Vivo | |
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| DNA Replication in Prokaryotes | |
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| Unique Aspects of Eukaryotic Chromosome Replication | |
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| Transcription and RNA Processing | |
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| Transfer of Genetic Information: The Central Dogma | |
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| The Process of Gene Expression | |
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| Transcription in Prokaryotes | |
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| Transcription and RNA Processing in Eukaryotes | |
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| Interrupted Genes in Eukaryotes: Exons and Introns | |
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| Removal of Intron Sequences by RNA Splicing | |
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| Translation and the Genetic Code | |
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| Protein Structure | |
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| One Gene—One Colinear Polypeptide | |
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| Protein Synthesis: Translation | |
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| The Genetic Code | |
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| Codon-tRNA Interactions | |
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| Mutation, DNA Repair, and Recombination | |
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| Mutation: Source of the Genetic Variability Required for Evolution | |
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| The Molecular Basis of Mutation | |
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| Mutation: Basic Features of the Process | |
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| Mutation: Phenotypic Effects | |
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| Assigning Mutations to Genes by the Complementation Test | |
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| Screening Chemicals for Mutagenicity: The Ames Test | |
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| DNA Repair Mechanisms | |
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| Inherited Human Diseases with Defects in DNA Repair | |
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| DNA Recombination Mechanisms | |
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| The Techniques of Molecular Genetics | |
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| Basic Techniques Used to Identify, Amplify, and Clone Genes | |
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| Construction and Screening of DNA Libraries | |
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| The Molecular Analysis of DNA, RNA, and Protein | |
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| The Molecular Analysis of Genes and Chromosomes | |
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| Genomics | |
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| Genomics: An Overview | |
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| Correlated Genetic, Cytological, and Physical Maps of Chromosomes | |
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| Map Position-Based Cloning of Genes | |
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| The Human Genome Project | |
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| RNA and Protein Assays of Genome Function | |
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| Comparative Genomics | |
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| Applications of Molecular Genetics | |
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| Use of Recombinant DNA Technology to Identify Human Genes and Diagnose Human Diseases | |
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| Molecular Diagnosis of Human Diseases | |
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| Human Gene Therapy | |
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| DNA Profiling | |
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| Production of Eukaryotic Proteins in Bacteria | |
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| Transgenic Plants and Animals | |
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| Reverse Genetics: Dissecting Biological Processes by Inhibiting Gene Expression | |
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| Transposable Genetic Elements | |
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| Transposable Elements: An Overview | |
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| Transposable Elements in Bacteria | |
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| Cut-and-Paste Transposons in Eukaryotes | |
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| Retroviruses and Retrotransposons | |
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| Transposable Elements in Humans | |
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| The Genetic and Evolutionary Significance of Transposable Elements | |
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| Regulation of Gene Expression in Prokaryotes | |
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| Constitutive, Inducible, and Repressible Gene Expression | |
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| Positive and Negative Control of Gene Expression | |
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| Operons: Coordinately Regulated Units of Gene Expression | |
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| The Lactose Operon in E. coli: Induction and Catabolite Repression | |
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| The Tryptophan Operon in E. coli: Repression and Attenuation | |
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| Translational Control of Gene Expression | |
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| Posttranslational Regulatory Mechanisms | |
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| Regulation of Gene Expression in Eukaryotes | |
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| Ways of Regulating Eukaryotic Gene Expression: An Overview | |
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| Induction of Transcriptional Activity by Environmental and Biological Factors | |
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| Molecular Control of Transcription in Eukaryotes | |
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| Posttranscriptional Regulation of Gene Expression by RNA Interference | |
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| Gene Expression and Chromatin Organization | |
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| Activation and Inactivation of Whole Chromosomes | |
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| The Genetic Control of Animal Development | |
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| A Genetic Perspective on Development | |
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| Maternal Gene Activity in Development | |
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| Genetic Analysis of Development in Vertebrates | |
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| The Genetic Basis of Cancer | |
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| Cancer: A Genetic Disease | |
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| Oncogenes | |
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| Tumor Suppressor Genes | |
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| Genetic Pathways to Cancer | |
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| Inheritance of Complex Traits | |
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| Complex Traits | |
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| Statistics of Quantitative Genetics | |
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| Analysis of Quantitative Traits | |
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| Correlations Between Relatives | |
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| Quantitative Genetics of Human Behavioral Traits | |
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| Population Genetics | |
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| The Theory of Allele Frequencies | |
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| Natural Selection | |
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| Random Genetic Drift | |
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| Populations in Genetic Equilibrium | |
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| Evolutionary Genetics | |
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| The Emergence of Evolutionary Theory | |
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| Genetic Variation in Natural Populations | |
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| Molecular Evolution | |
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| Speciation | |
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| Human Evolution | |
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| Appendices | |
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| The Rules of Probability | |
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| Binomial Probabilities | |
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| In Situ Hybridization | |
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| Evidence for an Unstable Messenger RNA | |
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| Evolutionary Rates | |
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| Answers to Odd-Numbered Questions and Problems | |
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| Glossary | |
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| Photo Credits | |
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| Illustration Credits | |
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| Index | |