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| Preface | |
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| Glossary of physical terms | |
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| The structures of biological macromolecules and lipid assemblies | |
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| General introduction | |
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| Protein structure | |
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| Carbohydrate structure | |
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| Nucleic acid structure | |
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| Macromolecular lipid assemblies | |
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| Structural forces in biological macromolecules | |
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| Chemical and biological synthesis | |
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| Introduction to synthesis in chemical biology | |
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| Chemical synthesis of peptides and proteins | |
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| Chemical synthesis of nucleic acids | |
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| Chemical synthesis of oligosaccharides | |
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| Chemical synthesis of lipids | |
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| Biological synthesis of biological macromolecules | |
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| Directed biological synthesis of proteins | |
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| Biological syntheses of nucleic acids, oligosaccharides and lipids | |
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| Molecular biology as a toolset for chemical biology | |
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| Key concepts in molecular biology | |
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| Tools and techniques in molecular biology | |
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| Cloning and identification of genes in DNA | |
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| Integrating cloning and expression | |
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| Site-directed mutagenesis | |
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| Electronic and vibrational spectroscopy | |
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| Electronic and vibrational spectroscopy in chemical biology | |
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| UV-visible spectroscopy | |
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| Circular dichroism spectroscopy | |
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| Vibrational spectroscopy | |
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| Fluorescence spectroscopy | |
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| Probing metal centres by absorption spectroscopy | |
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| Magnetic resonance | |
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| Magnetic resonance in chemical biology | |
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| Key principles of NMR | |
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| Two-dimensional NMR | |
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| Multi-dimensional NMR | |
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| Biological macromolecule structural information | |
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| EPR spectroscopy; key principles | |
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| Diffraction and microscopy | |
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| Diffraction and microscopy in chemical biology | |
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| Key principles of X-ray diffraction | |
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| Structural information from X-ray diffraction | |
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| Neutron diffraction | |
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| Key principles of electron microscopy | |
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| Key principles of scanning probe microscopy | |
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| Molecular recognition and binding | |
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| Molecular recognition and binding in chemical biology | |
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| Theoretical models of binding | |
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| Analysing molecular recognition and binding | |
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| Biological molecular recognition studies | |
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| Kinetics and catalysis | |
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| Catalysis in chemical biology | |
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| Steady state kinetic schemes | |
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| Pre-steady-state kinetics | |
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| Theories of biocatalysis | |
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| Electron transfer | |
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| Mass spectrometry and proteomics | |
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| Mass spectrometry in chemical biology | |
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| Key principles in mass spectrometry | |
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| Structural analysis of biological macromolecules and lipids by mass spectrometry | |
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| The challenge of proteomics | |
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| Genomics - assigning function to genes and proteins | |
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| Molecular selection and evolution | |
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| Chemical biology and the origins of life | |
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| Molecular breeding; natural selection acting on self-organisation | |
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| Directed evolution of protein function | |
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| Directed evolution of nucleic acids | |
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| Catalytic antibodies | |
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| References | |
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| Index | |