Essentials of Chemical Biology Structure and Dynamics of Biological Macromolecules

ISBN-10: 0470845317

ISBN-13: 9780470845318

Edition: 2005

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Description:

Biological Chemistry is a fast emerging branch of chemistry, which sets out to understand the molecular basis of life through a rigorous understanding of the detailed structure and behaviour of biomolecules. Filling a void in the currently available literature, Chemical Biology offers a comprehensive introduction to undergraduate and early postgraduate chemists to enhance their understanding of the underlying principles behind the functioning of biomolecules. Including many worked examples and problems, as well as a fully interactive website with useful links to further resources, this textbook actively encourages student understanding.
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Book details

List price: $102.95
Copyright year: 2005
Publisher: John Wiley & Sons, Incorporated
Publication date: 8/11/2008
Binding: Paperback
Pages: 590
Size: 7.75" wide x 10.00" long x 1.00" tall
Weight: 2.882
Language: English

Preface
Glossary of physical terms
The structures of biological macromolecules and lipid assemblies
General introduction
Protein structure
Carbohydrate structure
Nucleic acid structure
Macromolecular lipid assemblies
Structural forces in biological macromolecules
Chemical and biological synthesis
Introduction to synthesis in chemical biology
Chemical synthesis of peptides and proteins
Chemical synthesis of nucleic acids
Chemical synthesis of oligosaccharides
Chemical synthesis of lipids
Biological synthesis of biological macromolecules
Directed biological synthesis of proteins
Biological syntheses of nucleic acids, oligosaccharides and lipids
Molecular biology as a toolset for chemical biology
Key concepts in molecular biology
Tools and techniques in molecular biology
Cloning and identification of genes in DNA
Integrating cloning and expression
Site-directed mutagenesis
Electronic and vibrational spectroscopy
Electronic and vibrational spectroscopy in chemical biology
UV-visible spectroscopy
Circular dichroism spectroscopy
Vibrational spectroscopy
Fluorescence spectroscopy
Probing metal centres by absorption spectroscopy
Magnetic resonance
Magnetic resonance in chemical biology
Key principles of NMR
Two-dimensional NMR
Multi-dimensional NMR
Biological macromolecule structural information
EPR spectroscopy; key principles
Diffraction and microscopy
Diffraction and microscopy in chemical biology
Key principles of X-ray diffraction
Structural information from X-ray diffraction
Neutron diffraction
Key principles of electron microscopy
Key principles of scanning probe microscopy
Molecular recognition and binding
Molecular recognition and binding in chemical biology
Theoretical models of binding
Analysing molecular recognition and binding
Biological molecular recognition studies
Kinetics and catalysis
Catalysis in chemical biology
Steady state kinetic schemes
Pre-steady-state kinetics
Theories of biocatalysis
Electron transfer
Mass spectrometry and proteomics
Mass spectrometry in chemical biology
Key principles in mass spectrometry
Structural analysis of biological macromolecules and lipids by mass spectrometry
The challenge of proteomics
Genomics - assigning function to genes and proteins
Molecular selection and evolution
Chemical biology and the origins of life
Molecular breeding; natural selection acting on self-organisation
Directed evolution of protein function
Directed evolution of nucleic acids
Catalytic antibodies
References
Index
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