Metals in Medicine

ISBN-10: 0470681977

ISBN-13: 9780470681978

Edition: 2nd 2009

List price: $43.95
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Description: Metals in Medicine is a textbook directed a senior undergraduates and beginning graduate students, which describes metal-based agents for treating and diagnosing disease. Opening chapters present basic bonding concepts that are applicable to metallo-drugs and their biological targets, interactions that exist between the agents and substances in the biological milieu, basic pharmacokinetic and pharmacodynamic properties including transport and uptake of drugs by the cells, and methods for measuring efficacy and toxicity of agents. The steps from drug discovery to market place are also briefly outlined and discussed. These chapters lay the groundwork, in order that students can clearly understand how agents work, whatever their subject background.The remaining chapters focus on individual metallo-drugs and agents for treating and detecting disease, their synthesis, structure and general properties, known mechanism of action and important physical and chemical principles that apply. Throughout the book, "Feature Boxes" expand on features of drugs that are not directly related to studying metals in medicine, for example discovery, medical use, specialist assays, and metals in biology. At the end of the chapters there are specifically designed problems/exercises that apply basic kinetic, thermodynamic and chemical principles to practical problem solving in metals in medicine.

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Book details

List price: $43.95
Edition: 2nd
Copyright year: 2009
Publisher: John Wiley & Sons, Limited
Publication date: 11/13/2009
Binding: Paperback
Pages: 334
Size: 7.50" wide x 9.50" long x 0.75" tall
Weight: 1.430
Language: English

Inorganic Chemistry Basics
Crystal field theory
Molecular orbital theory
Absorption spectra of metal complexes
Magnetic properties of metal complexes
Reactions of metal complexes
Bibliography
References
Problems
Metallo-Drugs and Their Action
Introduction
Proteins as Targets for Metallo-Drugs
DNA as a target for Metallo-Drugs
Reactions of Metal Complexes in the Biological Milieu
Evaluating the Pharmacological Effects of Agents
From Discovery to the Marketplace and Beyond
Bibliography
References
Problems
Cisplatin
Physical and Chemical Properties of Cisplatin
Formulation, Administration, and Pharmacokinetics
Reaction of Cisplatin in Biological Media
Uptake, Cytotoxicity, and Resistance
Interaction of Cisplatin with Cellular Targets
Bibliography
References
Problems
Platinum Anticancer Drugs
Carboplatin
Oxaliplatin
New Platinum Agents
Bibliography
References
Problems
Ruthenium, Titanium, and Gallium for Treating Cancer
Ruthenium for Treating Cancer
Titanium Compound for Treating Cancer
Gallium for Treating Cancer
Bibliography
References
Problems
Gold Compounds for Treating Arthritis, Cancer, and Other Diseases
Chemistry of Gold in Biological Media
Gold Complexes for Treating Cancer
Gold Complexes for Treating AIDS and Other Diseases
Bibliography
References
Problems
Vanadium, Copper, and Zinc in Medicine
Vanadium for Treating Diabetes
Copper and Alzheimer's Disease
Copper in Wilson's and Menkes Diseases
Zinc-Bicyclam. A Cytokine Receptor Antagonist
Bibliography
References
Problems
Metal Complexes for Diagnosing Disease
Technetium-99m in diagnostic nuclear medicine
Metal compounds as contrast agents for MRI
Radionuclides for palliative care and cancer treatment
Bibliography
References
Problems
Nanomedicine
Nanoscience in Treating Disease
Nanoscience in Diagnosing Disease
Potential Health Risks of Nanoparticles
Sources
Literature Cited
Problems
Index
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