Basic Pharmacokinetics and Pharmacodynamics An Integrated Textbook and Computer Simulations

ISBN-10: 0470569069

ISBN-13: 9780470569061

Edition: 2011

List price: $85.95
eBook available
30 day, 100% satisfaction guarantee

If an item you ordered from TextbookRush does not meet your expectations due to an error on our part, simply fill out a return request and then return it by mail within 30 days of ordering it for a full refund of item cost.

Learn more about our returns policy

Description: There is a need for a straightforward, uncomplicated, basic, introductory book that presents only the material essential to provide a good foundation in pharmacokinetics and pharmacodynamics. This book fills that need; it is designed by the author to teach quantitative pharmacokinetics and pharmacodynamics in a novel way. It consists of the book and integrated interactive computer modules. Modules and exercises based on them are are available online via a companion website, and they are integrated into relevant parts of the book to reinforce the concepts presented.

eBooks Starting from $47.99
Buy
what's this?
Rush Rewards U
Members Receive:
coins
coins
You have reached 400 XP and carrot coins. That is the daily max!

Study Briefs

Limited time offer: Get the first one free! (?)

All the information you need in one place! Each Study Brief is a summary of one specific subject; facts, figures, and explanations to help you learn faster.

Add to cart
Study Briefs
Periodic Table Online content $4.95 $1.99
Add to cart
Study Briefs
Medical Terminology Online content $4.95 $1.99
Add to cart
Study Briefs
Medical Math Online content $4.95 $1.99

Customers also bought

Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading
Loading

Book details

List price: $85.95
Copyright year: 2011
Publisher: John Wiley & Sons, Incorporated
Publication date: 4/20/2011
Binding: Paperback
Pages: 448
Size: 7.00" wide x 9.82" long x 1.00" tall
Weight: 2.068
Language: English

Preface
Introduction to Pharmacokinetics and Pharmacodynamics
Introduction: Drugs and Doses
Introduction to Pharmacodynamics
Introduction to Pharmacokinetics
Dose-Response Relationships
Therapeutic Range
Summary
Passage of Drugs Through Membranes
Introduction
Structure and Properties of Membranes
Passive Diffusion
Carrier-Mediated Processes: Transport Proteins
Drug Administration, Absorption, and Bioavailability
Introduction: Local and Systemic Drug Administration
Common Routes of Systemic Drug Administration
Overview of Oral Absorption
Extent of Drug Absorption
Determinants of the Bioavailability
Factors Controlling the Rate of Drug Absorption
Biopharmaceutics Classification System
Problems
References
Drug Distribution
Introduction
Extent of Drug Distribution
Rate of Drug Distribution
Distribution of Drugs to the Central Nervous System
Problems
References
Drug Elimination and Clearance
Introduction
Clearance
Renal Clearance
Hepatic Clearance
Measurement of Clearances
Problems
References
Compartmental Models in Pharmacokinetics
Introduction
Expressions for Component Parts of the Dose-Plasma
Putting Everything Together: Compartments and Models
Examples of Complete Compartment Models
Use of Compartmental Models to Study Metabolite Pharmacokinetics
Selecting and Applying Models
Problems
Recommended Reading
Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model
Introduction
One-Compartment Model
Pharmacokinetic Equations
Simulation Exercise
Application of the Model
Determination of Pharmacokinetic Parameters Experimentally
Pharmacokinetic Analysis in Clinical Practice
Problems
Recommended Reading
Pharmacokinetics of an Intravenous Bolus Injection in a Two-Compartment Model
Introduction
Tissue and Compartment Distribution of a Drug
Basic Equation
Relationship Between Macro and Micro Rate Constants
Primary Pharmacokinetic Parameters
Simulation Exercise
Determination of the Pharmacokinetic Parameters of the Two-Compartment Model
Clinical Application of the Two-Compartment Model
Problems
Recommended Reading
Pharmacokinetics of Extravascular Drug Administration
Introduction
Model for First-Order Absorption in a One-Compartment Model
Bioavailability
Simulation Exercise
Problems
Recommended Reading
Introduction to Noncompartmental Analysis
Introduction
Mean Residence Time
Determination of Other Important Pharmacokinetic Parameters
Different Routes of Administration
Application of Noncompartmental Analysis to Clinical Studies
Problems
Pharmacokinetics of Intravenous Infusion in a One-Compartment Model
Introduction
Model and Equations
Steady-State Plasma Concentration
Loading Dose
Termination of Infusion
Individualization of Dosing Regimens
Problems
Multiple Intravenous Bolus Injections in the One-Compartment Model
Introduction
Terms and Symbols Used in Multiple-Dosing Equations
Monoexponential Decay During a Dosing Interval
Basic Pharmacokinetic Equations for Multiple Doses
Steady State
Basic Formula Revisited
Pharmacokinetic-Guided Dosing Regimen Design
Simulation Exercise
Problems
References
Multiple Intermittent Infusions
Introduction
Steady-State Equations for Multiple Intermittent
Monoexponential Decay During a Dosing Interval: Dtermination of Peaks, Troughs, and Elimination Half-Life
Determination of the Volume of Distribution
Individualization of Dosing Regimens
Simulation Exercise
Problems
Multiple Oral Doses
Introduction
Steady-State Equations
Equations Used Clinically to Individualize Oral Doses
Simulation Exercise
Problems
Nonlinear Pharmacokinetics
Linear Pharmacokinetics
Nonlinear Processes in Absorption, Distribution, Metabolism, and Elimination
Pharmacokinetics of Capacity-Limited Metabolism
Phenytoin
Problems
References
Introduction to Pharmacodynamic Models and Integrated Pharmacokinetic-Pharmacodynamic Models
Introduction
Classic Pharmacodynamic Models Based on Traditional Receptor Theory
Empirical Pharmacodynamic Models Used Clinically
Integrated PK-PD Models: E<sub>max</sub> Models Combined with a PK Model for Intravenous Bolus Infection in a One-Compartment Model
Hystersis and the Effect Compartment
Problems
References
Mechanism-Based Integrated Pharmacokinetic-Pharmacodynamic Models
Introduction
Alternative Models for Drug-Receptor Interaction: Operational Model of Agonism
Physiological Turnover Model and Its Characteristics
Indirect Effect Models
Transduction and Transit Compartment Models
Tolerance Models
Irreversible Drug Effects
Disease Progression Models
Problems
References
Review of Exponents and Logarithms
Rates of Processes
Creation of Excel Worksheets for Pharmacokinetic Analysis
Derivation of Equations for Multiple Intravenous Bolus Injections
Summary of the Properties of the Fictitious Drugs Used in the Text
Computer Simulation Models. Glossary of Abbreviations and Symbols
Index.
×
Free shipping on orders over $35*

*A minimum purchase of $35 is required. Shipping is provided via FedEx SmartPost® and FedEx Express Saver®. Average delivery time is 1 – 5 business days, but is not guaranteed in that timeframe. Also allow 1 - 2 days for processing. Free shipping is eligible only in the continental United States and excludes Hawaii, Alaska and Puerto Rico. FedEx service marks used by permission."Marketplace" orders are not eligible for free or discounted shipping.

Learn more about the TextbookRush Marketplace.

×