Dose Makes the Poison A Plain-Language Guide to Toxicology

ISBN-10: 0470381124
ISBN-13: 9780470381120
Edition: 3rd 2011
List price: $37.95 Buy it from $13.04
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Description: This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are  More...

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Book details

List price: $37.95
Edition: 3rd
Copyright year: 2011
Publisher: John Wiley & Sons, Incorporated
Publication date: 1/28/2011
Binding: Paperback
Pages: 284
Size: 6.25" wide x 9.25" long x 0.75" tall
Weight: 0.990
Language: English

This new edition of a widely-read and highly-acclaimed book broadens the scope of its predecessors from a heavy focus on industrial chemicals as toxicants to include drugs, food additives, cosmetics and other types of compounds that people are exposed to daily. Also new to the 3 rd edition are newer issues-of-the-day such as nanoparticulate toxicants, second hand smoke, food contamination, lead in toys , and others. As such, the book provides the basics of toxicology in easy-to-understand language as well as a fuller understanding of the daily insults to which our bodies are subjected.

Introduction to the Third Edition
Preface to the Second Edition
What Are Chemicals?
Atoms and Molecules
Natural Chemicals
Synthetic Chemicals
Chemical Categories
Chemicals: �Good� and �Bad�
Why the �Good-Bad� Dichotomy?
Man-made Chemicals Are Made by Humans
Man-made Chemicals May Not Be Biodegradable
Man-made Chemicals May Be Very Complex
What Harm Do Chemicals Cause?
Harmful Properties of Chemicals
Explosiveness and Reactivity
Flammability and Combustibility
Radioactivity
Corrosiveness
Irritation
Sensitization and Photosensitization
Toxicity
Multiple Harmful Properties
Definition of Poison
Definition of Hazard
What is Toxicology?
Empirical Toxicology
Paracelsus and Ramazzini
A Brief History of Toxicology
Toxicology Today
What Do Toxicologists Do?
What Factors Influence the Toxic Effects of Chemicals?
Acute versus Chronic Toxicity
Significance of Divided Doses
Routes of Exposure
Dermal Exposure
Inhalation Exposure
Oral Exposure
Other Routes of Exposure
Combinations
Influence of Route on Toxicity
Metabolism
Routes of Elimination (Excretion)
Other Factors that Influence Toxicity
Species
Sex
Age
Nutrition
State of Health
Biochemical Individuality (Genetic Diversity)
Presence of Other Chemicals
Adaptation
Light
How is Toxicology Studied?
Experimental Methods
Acute Toxicity
Irritant and Corrosive Effects
Sensitization and Photosensitization
Chronic Toxicity
Mutagenesis
Carcinogenesis
Developmental and Reproductive Toxicity
Units of Trace Quantities
Analytical Methods
Animal Rights
General Toxicology
Acute Toxicity
LD<sub>50</sub> and LC<sub>50</sub> Values
Significance of LDs for Humans
Poison Prevention
Antidotes
Chronic Toxicity
No-Effect Levels and Thresholds
Margins of Safety
Sufficient Challenge
Bioaccumulation
Mutagenesis and Carcinogenesis
Mutagenesis
Genetic Code
Mutations
Significance of Mutations
Mutation and Cancer
Carcinogenesis
What Is Cancer?
Causes of Cancer
Role of Mutation
Incidence of Cancer
Categories and Characteristics of Carcinogens
Induction Periods
Thresholds
Practical Thresholds
The Real World
Benzo[a]pyrene
Cancerophobia
Developmental and Reproductive Toxicity
Male and Female Reproductive Systems
Prepuberty Systems
Adult Systems
The Developing Individual
Case Studies in Toxicology
Environmental Contaminations
Dioxins: Seveso, Italy
PCBs and Dibenzofurans: Yusho Disease
Bophal, India
Minamata Disease
DDT
Consumer Products
Metals
Lead and Cadmium
Zinc
Plastics
Bisphenyl A
Indoor Air Pollution
Water Pollution
Pharmaceuticals
Fen-Phen
Vioxx
Thalidomide
Epidemiology
Origins of Modern Epidemiology
Epidemiology of Noninfectious Diseases
Koch's Postulates
Study Design: Precepts and Pitfalls
Unreasonable Expectations
Proximate Event Approach in Assigning Cause
Distrust of Science and Scientists
The Study of Risk
Public Health Statistics
Inherent Risk
Risk Assessment
Perceived Risk
Acceptable Risk
Risk Benefit and Cost Benefit
Risk Communication
Risk Management
Bibliography
Abbreviations
Glossary
Index

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